Abstract
The pathogenesis of vitiligo and schizophrenia has not been adequately clarified.
We explore the role of lipids in these diseases. Both conditions have been associated
with stress in several observations and studies. Research data indicate complex interactions
between oxidative stress and metabolic syndrome–with lipid abnormalities being a significant
component of the latter–in these diseases. The impaired membrane lipid homeostasis
mechanism is related to the increased phospholipid remodeling caused by excessive
oxidative stress in schizophrenia. We indicate that sphingomyelin is possibly involved
in the pathogenesis of these diseases. Statins have anti-inflammatory and immunomodulating
effects and an effect against oxidative stress. Preliminary clinical studies show
that these agents may be beneficial in both vitiligo and schizophrenia, but their
therapeutic value should be studied further.
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