Research Article| Volume 40, ISSUE 6, P691-699, November 2022

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History of leprosy in India: An overview of historic and modern contributions


      Traditionally, India holds the unenviable position of the origin of leprosy. The disease is thought to have spread, via trade and war, to China, Egypt, and the Middle East, and later to Europe and the Americas. From antiquity to modernity, Indian society treated leprosy singularly for custom and law, a response shaped by both scientific knowledge and cultural attitudes. Over the past centuries, tireless research by eminent physicians and scientists working in India have helped establish a better understanding of clinical, bacteriologic, pathologic, and immunologic aspects of leprosy. Therapeutic modalities that were initially restricted to chaulmoogra expanded to include newer anti-leprotic medications and even surgical reconstruction of deformities. India's future challenges in leprosy control include stigmata, educational knowledge gaps, and multiple systems of medicine. This contribution is an attempt to comprehensively discuss the historic aspect of this exclusive disease focusing on the varied scientific contributions from India.


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        • Dharmendra
        Leprosy in ancient Indian medicine.
        Int J Lepr. 1947; 15: 424-430
        • Robbins G
        • Tripathy VM
        • Misra VN
        • et al.
        Ancient skeletal evidence for leprosy in India (2000 B.C.).
        PLoS One. 2009; 4: e5669
        • Pandya SS
        Historical background.
        IAL Textbook of Leprosy. 2008; : 1-18
        • Carter HV.
        Case of anaesthetic leprosy with post-mortem examination and remarks.
        Transactions of the Medical and Physical Society of Bombay. 1862; VII: xxviii-xxxxix
        • Carter HV.
        On the symptoms and morbid anatomy of leprosy: with remarks.
        Transactions of the Medical and Physical Society of Bombay. Byculla: Education Societies Press;. 1862; VIII: 1-104
        • Carter HV.
        Report on leprosy and the leper asylums in Norway.
        Eyre & Spottiswoode, London1874: 27
        • Carter HV.
        Note on the pathology of leprosy. Maharashtra State Archives General Department, Publication No:14494, Mumbai1883
        • Virchow R.
        Virchow's leprosy: From Die Krankhaften Geschwulste (Berlin 1863), Part II; Transl. Fite GL.
        Int J Lepr India. 1954; 22: 205-216
        • Pandya SS.
        The first international leprosy conference, Berlin, 1897: the politics of segregation.
        Hist Cienc Saude Manguinhos. 2003; 10: 161-177
        • Ghosh JC.
        Indigenous drugs of India: their scientific cultivation and manufacturer with numerous suggestions intended for educationists and capitalists. Second edition. P.K. Ghosh, Calcutta1940
        • Manilal KS.
        Hortus malabaricus and the ethnoiatrical? Knowledge of ancient Malabar.
        Anc Sci Life. 1984; 4: 96-99
        • Rogers L.
        Preliminary note on the intravenous injection of gynocardates of soda in leprosy, with further experience of its subcutaneous use.
        BMJ. 1916; 2: 550-552
        • Rogers R.
        Two years’ experience of sodium gynocardates and chaulmoograte subcutaneously and intravenously in the treatment of leprosy.
        Indian J Med Res. 1917; 5: 277-300
        • Tomb JW.
        Chaulmoogra oil and its derivatives in the treatment of leprosy, Part III.
        J Trop Med Hyg. 1933; 36: 201-207
        • Cochrane RG.
        Leprosy in India and Ceylon.
        Lepr Rev. 1934; 5: 28-32
        • Mohanty J
        • Mohanty HC.
        Lepromin response with Dharmendra antigen in patients with leprosy.
        Indian J Dermatol Venereol Leprol. 1997; 63: 385-387
        • Dharmendra
        The lepromin test; a review.
        Lepr Rev. 1947; 18: 92-126
        • Sengupta U
        • Ramu G
        • Desikan KV.
        Assessment of Dharmendra antigen.
        Lepr India. 1978; 50: 599-609
        • Sehgal VN
        • Jain MK
        • Srivastava G
        Evolution of the classification of leprosy.
        Int J Dermatol. 1989; 28: 161-167
        • Chatterjee SN.
        The mechanism of the neural signs and symptoms of leprosy.
        Int J Lepr. 1955; 23: 1-18
        • Khanolkar VR
        Pathology of leprosy.
        in: Cochrane RG Davey TF Leprosy in Theory and Practice. John Wright and Son, Bristol, United Kingdom1964: 121-125
        • Deo MG
        • Bapat CV
        • Chullawalla RG
        • et al.
        Potential anti-leprosy vaccine from killed ICRC bacilli–a clinicopathological study.
        Indian J Med Res. 1981; 74: 164-177
        • Noordeen SK
        History of chemotherapy of leprosy.
        Clin Dermatol. 2016; 34: 32-36
        • Muir E.
        Preliminary report on 4:4′ diamino diphenyl sulfone (DDS) treatment of leprosy.
        Int J Lepr. 1950; 18: 299-308
        • Browne SG
        • Hogerzeil LM.
        B 663" in the treatment of leprosy. Preliminary report of a pilot trial.
        Lepr Rev. 1962; 33: 6-10
        • Anita NH
        • Vankani B
        • Pandya NJ.
        Surgical decompression of the ulnar nerve in leprous neuritis.
        Lepr India. 1976; 48: 362-370
        • Nash JE
        Paul Wilson Brand.
        BMJ. 2003; 327: 292
        • Mukhopadhyay AK.
        Dermatology in India and Indian dermatology: a medico-historical perspective.
        Indian Dermatol Online J. 2016; 7: 235-243
        • Mushtaq MU.
        Public health in British India: a brief account of the history of medical services and disease prevention in colonial India.
        Indian J Community Med. 2009; 34: 6-14
        • Kumar A.
        Achievements of National Leprosy Eradication Programme (NLEP) in India.
        Indian J Public Health. 2003; 47: 171-179
        • Sehgal VN.India dermatology
        Int J Dermatol. 1993; 32: 838-844
        • Thappa DM.
        History of dermatology, venereology, and leprology in India.
        J Postgrad Med. 2002; 48: 160-165
        • Robertson J.
        The leprosy asylum in India: 1886-1947.
        J Hist Med Allied Sci. 2009; 64: 474-517
        • Premkumar R.
        The history of a leprosy sanatorium in India. A literature review.
        Lepr Rev. 2010; 81: 150-159
        • Vongsathorn K
        Gnawing pains, festering ulcers, and nightmare suffering: selling leprosy as a humanitarian cause in the British Empire, c. 1890-1960.
        J Imp Commonw Hist. 2012; 40: 863-878
        • Glucklich A.
        Laws for the sick and handicapped in the Dharmaśāstra.
        South Asia Res. 1984; 4: 139-152
        • Dharmendra
        Repeal of the Lepers Act, 1898.
        Lepr India. 1983; 55: 633-639
      1. OneWorld South Asia. Laws in India Criminalise Leprosy. Available at: Accessed October 31, 2021.

      2. Dosa P. Gandhi. Parchure and Stigma of leprosy. Available at: Accessed on October 31, 2021.

      3. WHO. Realizing Mahatma Gandhi's dream of a leprosy-free India. Available at: Accessed October 31, 2021.