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In response to “Cannabis and the skin” by Shao et al

      To the Editor: We read with interest the review titled “Cannabis and the skin”
      • Shao K
      • Stewart C
      • Grant-Kels JM.
      Cannabis and the skin.
      and wish to highlight it, as the presentation addresses the medical uses of cannabis in dermatologic conditions and those that remain to be tested in order to encourage investigation of the subject. We think it could be important to explain the release process of endocannabinoids in the body, allowing readers to have a better understanding of how phytocannabinoids and synthetic cannabinoids are therapeutic. The endocannabinoid system is formed by the endocannabinoids, enzymes, receptors, and precursors that are in the lipid membranes (phospholipids) of cells. Endocannabinoids are synthesized on demand; subsequently, they pass to the extracellular space and are released to circulation.
      • Lu H-C
      • Mackie K.
      An introduction to the endogenous cannabinoid system.
      Cannabinoid receptors are found throughout the body, centrally and peripherally in the epidermal keratinocytes, hair follicles, melanocytes, fibroblasts, and sebaceous and sweat glands, which are involved in physiological process and therefore are therapeutic targets.
      • Bukiya AN
      Recent Advances in Cannabinoid Physiology and Pathology.

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      References

        • Shao K
        • Stewart C
        • Grant-Kels JM.
        Cannabis and the skin.
        Clin Dermatol. 2021; 39: 784-975
        • Lu H-C
        • Mackie K.
        An introduction to the endogenous cannabinoid system.
        Biol Psychiatry. 2016; 79: 516-525
        • Bukiya AN
        Recent Advances in Cannabinoid Physiology and Pathology.
        Springer International Publishing, Cham, Switzerland2019
        • Cogan PS.
        The 'entourage effect' or 'hodge-podge hashish': the questionable rebranding, marketing, and expectations of cannabis polypharmacy.
        Expert Rev Clin Pharmacol. 2020; 13: 835-845