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Correspondence Edited by Stephen P. Stone, MD| Volume 40, ISSUE 4, P396, July 01, 2022

In response to “Cannabis and the skin” by Shao et al

Published:March 03, 2022DOI:https://doi.org/10.1016/j.clindermatol.2022.01.004
In response to “Cannabis and the skin” by Shao et al
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      To the Editor: We read with interest the review titled “Cannabis and the skin”
      • Shao K
      • Stewart C
      • Grant-Kels JM.
      Cannabis and the skin.
      Clin Dermatol. 2021; 39: 784-975
      and wish to highlight it, as the presentation addresses the medical uses of cannabis in dermatologic conditions and those that remain to be tested in order to encourage investigation of the subject. We think it could be important to explain the release process of endocannabinoids in the body, allowing readers to have a better understanding of how phytocannabinoids and synthetic cannabinoids are therapeutic. The endocannabinoid system is formed by the endocannabinoids, enzymes, receptors, and precursors that are in the lipid membranes (phospholipids) of cells. Endocannabinoids are synthesized on demand; subsequently, they pass to the extracellular space and are released to circulation.
      • Lu H-C
      • Mackie K.
      An introduction to the endogenous cannabinoid system.
      Biol Psychiatry. 2016; 79: 516-525
      Cannabinoid receptors are found throughout the body, centrally and peripherally in the epidermal keratinocytes, hair follicles, melanocytes, fibroblasts, and sebaceous and sweat glands, which are involved in physiological process and therefore are therapeutic targets.
      • Bukiya AN
      Recent Advances in Cannabinoid Physiology and Pathology.
      Springer International Publishing, Cham, Switzerland2019

      Keywords

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      References

        • Shao K
        • Stewart C
        • Grant-Kels JM.
        Cannabis and the skin.
        Clin Dermatol. 2021; 39: 784-975
        View in Article
        • Lu H-C
        • Mackie K.
        An introduction to the endogenous cannabinoid system.
        Biol Psychiatry. 2016; 79: 516-525
        View in Article
        • Bukiya AN
        Recent Advances in Cannabinoid Physiology and Pathology.
        Springer International Publishing, Cham, Switzerland2019
        View in Article
        • Cogan PS.
        The 'entourage effect' or 'hodge-podge hashish': the questionable rebranding, marketing, and expectations of cannabis polypharmacy.
        Expert Rev Clin Pharmacol. 2020; 13: 835-845
        View in Article

      Article Info

      Publication History

      Published online: March 03, 2022
      Accepted: January 13, 2022
      Received in revised form: January 13, 2022
      Received: January 4, 2022

      Identification

      DOI: https://doi.org/10.1016/j.clindermatol.2022.01.004

      Copyright

      © 2022 Elsevier Inc. All rights reserved.

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