To the Editor: We read with interest the review titled “Cannabis and the skin”
1
and wish to highlight it, as the presentation addresses the medical uses of cannabis
in dermatologic conditions and those that remain to be tested in order to encourage
investigation of the subject. We think it could be important to explain the release
process of endocannabinoids in the body, allowing readers to have a better understanding
of how phytocannabinoids and synthetic cannabinoids are therapeutic. The endocannabinoid
system is formed by the endocannabinoids, enzymes, receptors, and precursors that
are in the lipid membranes (phospholipids) of cells. Endocannabinoids are synthesized
on demand; subsequently, they pass to the extracellular space and are released to
circulation.
2
Cannabinoid receptors are found throughout the body, centrally and peripherally in
the epidermal keratinocytes, hair follicles, melanocytes, fibroblasts, and sebaceous
and sweat glands, which are involved in physiological process and therefore are therapeutic
targets.
3
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinics in DermatologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Cannabis and the skin.Clin Dermatol. 2021; 39: 784-975
- An introduction to the endogenous cannabinoid system.Biol Psychiatry. 2016; 79: 516-525
- Recent Advances in Cannabinoid Physiology and Pathology.Springer International Publishing, Cham, Switzerland2019
- The 'entourage effect' or 'hodge-podge hashish': the questionable rebranding, marketing, and expectations of cannabis polypharmacy.Expert Rev Clin Pharmacol. 2020; 13: 835-845
Article info
Publication history
Published online: March 03, 2022
Accepted:
January 13,
2022
Received in revised form:
January 13,
2022
Received:
January 4,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
