Advertisement

Nail involvement in autosomal recessive congenital ichthyosis

      Abstract

      Autosomal recessive congenital ichthyosis (ARCI) is a clinically and genetically heterogeneous category of nonsyndromic ichthyosis. Nail changes in ARCI are generally frequent but have been rarely reported and studied in the literature. This stimulated us to conduct a study to describe nail changes in ARCI using a combined literature review and prospective examination from March 2019 to August 2019 (6 months) in the Dermatology Department of Habib Thameur Hospital, Tunis, Tunisia. A total of 25 patients with ARCI had a clinical and dermatoscopic review. The mean age was 19.8 years (range, 1-43), with a female predominance (17 women [68%] and 8 men [32%]). Seventy-two percent had nail unit changes involving more than one nail, none had single nail disease, 64% had involvement of fingernails, and 68% had involvement of toenails, with cases including periungual hyperkeratosis (64%), xanthonychia (40%), pachyonychia (40%), macrolunula (36%), digital clubbing (32%), and onychomycosis (24%). Rarer findings included pseudoainhum, transverse leukonychia, longitudinal melanonychia, and subungual hemorrhages, each in one patient (4%). There was a statistically significant increased frequency of nail changes in adults over children (P = .001). Nail abnormalities statistically associated with ARCI were macrolunula, periungual hyperkeratosis, xanthonychia, and pachyonychia. A comprehensive review of the literature was performed, creating the first comprehensive review addressing nail disease in ARCI.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Clinics in Dermatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Oji V
        • Tadini G
        • Akiyama M
        • et al.
        Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009.
        J Am Acad Dermatol. 2010; 63: 607-641
        • Rodríguez-Pazos L
        • Ginarte M
        • Vega A
        • et al.
        Autosomal recessive congenital ichthyosis.
        Actas Dermo-Sifiliográficas Engl Ed. 2013; 104: 270-284
        • Radner FPW
        • Marrakchi S
        • Kirchmeier P
        • et al.
        Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans.
        PLoS Genet. 2013; 9e1003536
        • Belyayeva E
        • Gregoriou S
        • Chalikias J
        • et al.
        The impact of nail disorders on quality of life.
        Eur J Dermatol. 2013; 23: 366-371
        • Ghosh A
        • Ahar R
        • Chatterjee G
        • et al.
        Clinico-epidemiological study of congenital ichthyosis in a tertiary care center of Eastern India.
        Indian J Dermatol. 2017; 62: 606-611
        • Wortsman X
        • Aranibar L
        • Morales C.
        Postnatal 2- and 3-dimensional sonography of the skin and nail in congenital autosomal recessive ichthyosis correlated with cutaneous histologic findings.
        J Ultrasound Med. 2011; 30: 1437-1439
        • Ena P
        • Pinna A.
        Lamellar ichthyosis associated with pseudoainhum of the toes and eye changes.
        Clin Exp Dermatol. 2003; 28: 493-495
        • Grimm V
        • Mohrenschlager M
        • Schuhmachers E
        • et al.
        Hourglass-like leuconychia in congenital lamellar ichthyosis.
        Br J Dermatol. 2004; 150: 619-620
        • Vyas NS
        • Kannan S
        • Jahnke MN
        • et al.
        Congenital ichthyosiform erythroderma superimposed with chronic dermatophytosis: a report of three siblings.
        Pediatr Dermatol. 2016; 33: e6-e9
        • Bochner R
        • Samuelov L
        • Sarig O
        • et al.
        Calpain 12 function revealed through the study of an atypical case of autosomal recessive congenital ichthyosis.
        J Invest Dermatol. 2017; 137: 385-393
        • Deffenbacher B.
        Successful experimental treatment of congenital ichthyosis in an infant.
        BMJ Case Rep. 2013; bcr2013008688
        • Behera B
        • Chandrashekar L
        • Singh N
        • et al.
        Lamellar ichthyosis associated bilateral pseudoainhum of fingers and toes successfully treated with tazarotene.
        Dermatol Ther. 2017; 30: e12516
        • Sheetz K
        • Lynch PJ.
        Ichthyosis and dermatophyte fungal infection.
        J Am Acad Dermatol. 1991; 24: 321
        • Szlávicz E
        • Németh C
        • Szepes É
        • et al.
        Congenital ichthyosis associated with Trichophyton rubrum tinea, imitating drug hypersensitivity reaction.
        Med Mycol Case Rep. 2020; 29: 15-17
        • Jorizzo JL
        • Crounse RG
        • Wheeler CE.
        Lamellar ichthyosis, dwarfism, mental retardation, and hair shaft abnormalities.
        J Am Acad Dermatol. 1980; 2: 309-317
        • Baden HP
        • Imber M.
        Ichthyosis with an unusual constellation of ectodermal dysplasias.
        Clin Genet. 2008; 35: 455-461
        • Zweegers J
        • Bovenschen HJ.
        Acitretin-induced transverse leukonychia.
        Int J Dermatol. 2014; 53: e221-e222
        • Aydogan K
        • Karadogan SK
        • Tunali S.
        Acitretin-induced subungual hemorrhage.
        Int J Dermatol. 2007; 46: 494-495
        • Chan A
        • Godoy-Gijon E
        • Nuno-Gonzalez A
        • et al.
        Cellular basis of secondary infections and impaired desquamation in certain inherited ichthyoses.
        JAMA Dermatol. 2015; 151: 285
        • de Freitas CFNP
        • F Mulinari-Brenner
        • Fontana HR
        • Gentili AC
        • Hammerschmidt M
        Ichthyosis associated with widespread tinea corporis: report of three cases.
        An Bras Dermatol. 2013; 88: 627-630
        • Goulden V
        • Goodfield MJD.
        Treatment of childhood dermatophyte infections with oral terbinafine.
        Pediatr Dermatol. 1995; 12: 53-54
        • James WD.
        Twenty-nail dystrophy and ichthyosis vulgaris.
        Arch of Dermatol. 1981; 117: 316
        • Basu P
        • Cohen P.
        Macrolunula: case reports of patients with trauma-associated enlarged lunula and a concise review of this nail finding.
        Cureus. 2018; 10: e2998
        • Tontchev G
        • Silverberg NB
        • Shlasko E
        • et al.
        Techniques for toddlers: linear band incision for harlequin ichthyosis with associated compartment syndrome.
        Pediatr Dermatol. 2014; 31: 625-629
        • Chang P
        • Meaux T.
        Onychogryphosis: a report of ten cases.
        Skinmed. 2015; 13: 355-359