Abstract
Optoacoustic imaging (OAI) is a hybrid imaging modality that integrates the benefits
of optical contrast and ultrasound detection. Raster-scan optoacoustic mesoscopy (RSOM)
is an emerging OAI method that provides information about several dermatological conditions’
structural, functional, and molecular features. We searched PubMed and Google Scholar
databases through September 2021 for contributions relevant to OAI in the English
language. This review contains 32 studies and other relevant literature. Several studies
indicate that RSOM is helpful in inflammatory skin conditions such as psoriasis and
eczema, especially as it allows more accurate quantification of inflammation-related
alterations such as changes to the dermal vasculature. In psoriasis, RSOM can provide
objective early diagnosis and monitoring of disease activity and treatment efficacy.
Multispectral RSOM, a method in which skin is lightened at more than a single wavelength,
is beneficial in diagnosing and monitoring hypoxia-associated conditions, such as
systemic sclerosis and chronic wounds. OAI techniques can visualize the pathologicvascularization
of skin cancers and quantify their oxygenation status which helps differentiate them
from normal skin. Also, they can measure the depth of malignant melanoma and detect
the metastatic spread of melanoma cells to sentinel lymph nodes. As demonstrated in
this contribution, there is a large spectrum of potential applications of OAI imaging,
especially RSOM, in diagnosing, treating, and managing skin diseases.
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Article info
Publication history
Published online: December 16, 2021
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