Abstract
Perioral rhytides are a common reason for presentation to the cosmetic dermatologist.
Various treatment options exist, and it can be challenging to determine the optimal
technique to use in a given patient encounter. We herein provide a review article
highlighting various treatment options in the correction of perioral rhytides, focusing
on the roles of neurotoxin, filler, microneedling (with and without radiofrequency),
fractional resurfacing (nonablative and ablative), and fully ablative lasers, with
a brief mention of deep chemical peels. For each modality, we review the evidence
behind the specific technique, its advantages and disadvantages, post-procedural effects,
expected downtime, as well as the onset and duration of desired effects. Despite longstanding
debate regarding the "best" modality to use, we instead propose that the best approach
is a combination approach which takes into account he patient's treatment goals while
staying consistent with the expected amount of downtime. Importantly, we share clinical
pearls based on the senior authors direct patient experience as Director of Laser
and Cosmetic Dermatology at University of California, San Diego (UCSD).
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinics in DermatologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Current concepts in lip augmentation.Cutis. 2016; 98: 325-329
- Anatomic considerations, analysis, and the aging process of the perioral region.Facial Plast Surg Clin North Am. 2007; 15: 403-407
- OnabotulinumtoxinA dose-ranging study for hyperdynamic perioral lines.Dermatol Surg. 2012; 38: 1497-1505
- Superficial dermal injection of hyaluronic acid soft tissue fillers: comparative ultrasound study.Dermatol Surg. 2012; 38: 1162-1169
- Perioral rejuvenation: restoration of attractiveness in aging females by minimally invasive procedures.Clin Interv Aging. 2013; 8: 1149-1155
- A review of hydrolifting: a new modality for skin rejuvenation.J Cosmet Laser Ther. 2018; 20: 28-33
- Multicenter, randomized, parallel-group study of the safety and effectiveness of onabotulinumtoxinA and hyaluronic acid dermal fillers (24-mg/ml smooth, cohesive gel) alone and in combination for lower facial rejuvenation.Dermatol Surg. 2010; 36: 2121-2134
- Microneedling: a comprehensive review.Dermatol Surg. 2017; 43: 321-339
- Microneedling: a review and practical guide.Dermatol Surg. 2018; 44: 397-404
- A comparative analysis of electric and radiofrequency microneedling devices on the market.J Drugs Dermatol. 2018; 17: 1010-1013
- Ensuring consistent results when microneedling perioral rhytides.Dermatol Surg. 2018; 44: 595-597
- Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity.Plast Reconstr Surg. 2008; 121: 1421-1429
- Skin needling in the treatment of the aging neck.Skinmed. 2011; 9: 347-351
- Prospective, preclinical comparison of the performance between radiofrequency microneedling and microneedling alone in reversing photoaged skin.J Cosmet Dermatol. 2020; 19: 1105-1109
- Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction.Lasers Surg Med. 2016; 48: 140-149
- Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury.Lasers Surg Med. 2004; 34: 426-438
- 35-month profilometric and clinical evaluation of non-ablative remodeling using a 1540-nm Er:glass laser.J Cosmet Laser Ther. 2004; 6: 126-130
- Nonablative laser skin resurfacing using a 1540 nm erbium glass laser: a clinical and histologic analysis.Dermatol Surg. 2002; 28: 833-835
- Treatment of photoaging with a dual-wavelength, 532 nm and 1,064 nm picosecond-domain laser producing a fractionated treatment beam using a holographic optic.J Drugs Dermatol. 2017; 16: 1077-1082
- Treatment of facial rhytides with a nonablative 1,450-nm diode laser: a controlled clinical and histologic study.Dermatol Surg. 2003; 29: 124-128
- Micro-fractional ablative skin resurfacing with two novel erbium laser systems.Lasers Surg Med. 2008; 40: 113-123
- Fractional carbon dioxide laser resurfacing of rhytides and photoageing: a prospective study using profilometric analysis.Br J Dermatol. 2014; 170: 858-865
- Pulsed CO2 laser tissue ablation: effect of tissue type and pulse duration on thermal damage.Lasers Surg Med. 1988; 8: 108-118
- Modulating the Er:YAG laser.Lasers Surg Med. 2000; 26: 223-226
- Variable pulse erbium:YAG laser skin resurfacing of perioral rhytides and side-by-side comparison with carbon dioxide laser.Lasers Surg Med. 2000; 26: 208-214
- Pulsed carbon dioxide and erbium-YAG laser resurfacing: a comparative clinical and histologic study.J Cutan Laser Ther. 1999; 1: 29-35
- The safety and effectiveness of single-pass erbium:YAG laser in the treatment of mild to moderate photodamage.Dermatol Surg. 2004; 30: 1073-1076
- One-pass CO2 versus multiple-pass Er:YAG laser resurfacing in the treatment of rhytides: a comparison side-by-side study of pulsed CO2 and Er:YAG lasers.Dermatol Surg. 2001; 27: 709-715
- An examination of the phenol-croton oil peel: part IV. Face peel results with different concentrations of phenol and croton oil.Plast Reconstr Surg. 2000; 105: 1061-1083
- Segmental phenol-croton oil chemical peels for treatment of periorbital or perioral rhytides.J Am Acad Dermatol. 2019; 81: e165-e166
- Abdel Halim D. Non-ablative 1540 fractional laser: how far could it help injection lipolysis and dermal fillers in lower-face rejuvenation? A randomized controlled trial.J Cosmet Laser Ther. 2013; 15: 13-20
- The skin rejuvenation associated treatment-Fraxel laser, Microbotox, and low G prime hyaluronic acid: preliminary results.Lasers Med Sci. 2019; 34: 1449-1455
- Safety of laser-assisted delivery of topical poly-L-lactic acid in the treatment of upper lip rhytides: a prospective, rater-blinded study.Dermatol Surg. 2019; 45: 968-974
- Botulinum toxin type A gives adjunctive benefit to periorbital laser resurfacing.J Cosmet Laser Ther. 2004; 6: 145-148
Article info
Publication history
Published online: November 24, 2021
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.