Abstract
Nutrition and dietary supplements are commonly used in the management of psoriasis;
however, evidence of their efficacy is inconsistent. Although some dietary interventions
have been shown to improve psoriasis consistently, others have little evidence supporting
their use. We review common dietary interventions for the management of psoriasis
and the evidence behind them. Caloric restriction, especially in overweight and obese
individuals, has been shown to consistently diminish psoriatic activity. Evidence
about other supplements and dietary interventions is inconsistent. Given the cost
and side effects of pharmaceutical treatments for psoriasis, larger, long-term studies
on the use of nutrition for the management of psoriasis are necessary.
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References
- Dietary recommendations for adults with psoriasis or psoriatic arthritis from the medical board of the national psoriasis foundation: a systematic review.JAMA Dermatol. 2018; 154: 934-950
- Omega-3 fatty acid–based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial.J Am Acad Dermatol. 1998; 38: 539-547
- Study on the use of omega-3 fatty acids as a therapeutic supplement in treatment of psoriasis.Clin Cosmet Investig Dermatol. 2011; 4: 73-77
- Effect of dietary supplementation with very-long-chain n-3 fatty acids in patients with psoriasis.N Engl J Med. 1993; 328: 1812-1816
- Consumption of polyunsaturated fatty acids and risk of incident psoriasis and psoriatic arthritis from the Nurses’ Health Study II.Br J Dermatol. 2017; 177: 302-306
- Effects of fish oil supplement on psoriasis: a meta-analysis of randomized controlled trials.BMC Complement Altern Med. 2019; 19: 354
- Alcohol consumption and psoriasis: a systematic literature review.J Eur Acad Dermatol Venereol. 2013; 27: 30-35
- Critical role of environmental factors in the pathogenesis of psoriasis.J Dermatol. 2017; 44: 863-872
- Alcohol consumption and psoriatic risk: a meta-analysis of case–control studies.J Dermatol. 2012; 39: 770-773
- Alcohol consumption: is it really a risk factor for psoriasis?.J Dermatol. 2013; 40: 508
- Alcohol intake and risk of incident psoriasis in US women: a prospective study.Arch Dermatol. 2010; 146: 1364-1369
- Smoking, but not alcohol, is associated with risk of psoriasis in a Taiwanese population-based cohort study.J Am Acad Dermatol. 2019; 80: 727-734
- Alcohol intake measured by phosphatidylethanol in blood and the lifetime drinking history interview are correlated with the extent of psoriasis.Dermatology. 2015; 230: 375-380
- Alcohol and psoriasis: sobering thoughts.Clin Exp Dermatol. 2013; 38: 819-822
- Effect of weight loss on the severity of psoriasis: a randomized clinical study.JAMA Dermatol. 2013; 149: 795-801
- Diet and physical exercise in psoriasis: a randomized controlled trial.Br J Dermatol. 2014; 170: 634-642
- Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: a systematic review and meta-analysis.Int J Obes. 2015; 39: 1197-1202
- The effect of weight reduction on treatment outcomes in obese patients with psoriasis on biologic therapy: a randomized controlled prospective trial.Expert Opin Biol Ther. 2014; 14: 749-756
- Diet and weight loss as a treatment for psoriasis.Arch Dermatol. 2010; 146: 544-546
- The impact of Ramadan fasting on the reduction of PASI score, in moderate-to-severe psoriatic patients: A real-life multicenter study.Nutrients. 2019; 11: 277
- Weight loss improves disease activity in patients with psoriatic arthritis and obesity: an interventional study.Arthritis Res Ther. 2019; 21: 17
- Bariatric surgery and the incidence of psoriasis and psoriatic arthritis in the Swedish obese subjects study.Obesity (Silver Spring). 2017; 25: 2068-2073
- Incidence and prognosis of psoriasis and psoriatic arthritis in patients undergoing bariatric surgery.JAMA Surg. 2017; 152: 344-349
- Psoriasis improvement after bariatric surgery.Surg Obes Relat Dis. 2014; 10: 1155-1159
- Rapid remission of psoriasis after sleeve gastrectomy.Indian J Surg. 2016; 78: 60-62
- Remission of psoriasis after open gastric bypass.Obesity Surg. 2006; 16: 94-97
- Metabolic syndrome and the skin: a more than superficial association. Reviewing the association between skin diseases and metabolic syndrome and a clinical decision algorithm for high risk patients.Diabetol Metab Syndr. 2018; 10: 9
- An update on psoriasis and metabolic syndrome: a meta-analysis of observational studies.PLoS One. 2017; 12e0181039
- Elevated odds of metabolic syndrome in psoriasis: a population-based study of age and sex differences.Br J Dermatol. 2015; 172: 419-427
- Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.Eur Acad Dermatol Venereol. 2019; 33: 128-135
- Metabolic syndrome in patients with psoriatic disease.J Rheumatol Suppl. 2012; 89: 24-28
- Psoriasis and the metabolic syndrome.Clin Dermatol. 2018; 36: 21-28
- Prevalence of metabolic syndrome in Chinese psoriasis patients: a hospital-based cross-sectional study.J Diabetes Investig. 2018; 9: 39-43
- Prevalence of the metabolic syndrome in psoriasis: results from the national health and nutrition examination survey, 2003-2006.Arch Dermatol. 2011; 147: 419-424
- Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom.J Invest Dermatol. 2012; 132: 556-562
- Prevalence of metabolic syndrome in psoriasis patients and its relation to disease duration: a hospital based case-control study.J Clin Diagn Res. 2016; 10: WC01-WWC5
- Association of metabolic syndrome in chronic plaque psoriasis patients and their correlation with disease severity, duration and age: a case control study from western Maharashtra.J Clin Diagn Res. 2017; 11: WC06-WC10
- Links and risks associated with psoriasis and metabolic syndrome.Psoriasis (Auckl). 2015; 5: 125-128
- Psoriasis and metabolic syndrome.Med Arch. 2015; 69: 85-87
- Psoriasis, metabolic syndrome and cardiovascular risk factors. A population-based study.J Eur Acad Dermatol Venereol. 2019; 33: 128-135
- Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based cross-sectional study.An Bras Dermatol. 2017; 92: 46-51
- Definition of the Mediterranean diet; a literature review.Nutrients. 2015; 7: 9139-9153
- Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?.J Transl Med. 2015; 13: 18
- Association between Mediterranean anti-inflammatory dietary profile and severity of psoriasis: results from the NutriNet-Santé cohort.JAMA Dermatol. 2018; 154: 1017-1024
- Adherence to the Mediterranean diet is independently associated with psoriasis risk, severity, and quality of life: a cross-sectional observational study.Int J Dermatol. 2019; 58: e164-e165
- Psoriasis and risk of celiac disease: a systematic review and meta-analysis.Indian J Dermatol. 2017; 62: 41-46
- Diet and psoriasis, part II: celiac disease and role of a gluten-free diet.J Am Acad Dermatol. 2014; 71: 350-358
- Association between coeliac disease and psoriasis: Italian primary care multicentre study.Dermatology. 2015; 230: 156-160
- Coeliac disease-associated antibodies in psoriasis.Ann Dermatol. 2013; 25: 298-303
- Dietary behaviors in psoriasis: patient-reported outcomes from a U.S. national survey.Dermatol Ther (Heidelb). 2017; 7: 227-242
- Serum homocysteine level, vitamin B12 levels, and erythrocyte folate in psoriasis: a case-control study.Int J Womens Dermatol. 2019; 5: 171-174
- Homocysteine, vitamin B12 and folic acid levels in psoriasis patients.J Eur Acad Dermatol Venereol. 2009; 23: 300-303
- Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity.Int J Immunopathol Pharmacol. 2010; 23: 911-916
- Serum homocysteine, folate and vitamin B12 levels in patients with psoriasis: a systematic review and meta-analysis.Br J Dermatol. 2019; 180: 382-389
- Is vitamin B12 of value in psoriasis?.Br Med J. 1962; 2: 1729-1730
- Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis.Int J Immunopathol Pharmacol. 2017; 30: 439-444
- Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis.Dermatology. 2001; 203: 141-147
- Vitamin D and its role in psoriasis: an overview of the dermatologist and nutritionist.Endocr Metab Disord. 2017; 18: 195-205
- Topical vitamin D analogues alone or in association with topical steroids for psoriasis: a systematic review.J Eur Acad Dermatol Venereol. 2012; 26: 52-60
- Prevalence of vitamin D deficiency and associated risk factors in the US population (2011-2012).Cureus. 2018; 10: e2741
- Vitamin D deficiency in Europe: pandemic?.Am J Clin Nutr. 2016; 103: 1033-1044
- Association between psoriasis and vitamin D: duration of disease correlates with decreased vitamin D serum levels: an observational case-control study.Medicine (Baltimore). 2018; 97: e11185
- Serum vitamin D level—the effect on the clinical course of psoriasis.Postepy Dermatol Alergol. 2016; 33: 445-449
- The relevance of serum vitamin D in psoriasis: a review.Arch Dermatol Res. 2017; 309: 499-517
- Low vitamin D in psoriasis: reality or myth?.Indian J Dermatol. 2018; 63: 255-260
- Oral vitamin D3 supplementation for chronic plaque psoriasis: a randomized, double-blind, placebo-controlled trial.J Dermatol Treat. 2018; 29: 648-657
- The clinical effect of oral vitamin D2 supplementation on psoriasis: a double-blind, randomized, placebo-controlled study.Dermatol Res Pract. 2019; 20195237642
- Screening of effects of selenomethionine-enriched yeast supplementation on various immunological and chemical parameters of skin and blood in psoriatic patients.Acta Derm Venereol. 1993; 73: 88-91
- Soluble tumor necrosis factor-alpha receptor type 1 during selenium supplementation in psoriasis patients.Nutrition. 2003; 19: 847-850
- Vitamin D toxicity—a clinical perspective.Front Endocrinol (Lausanne). 2018; 9: 550
- The effect of supplementation with selenium and vitamin E in psoriasis.Ann Clin Biochem. 1989; 26: 83-88
- Clinical and biochemical effects of coenzyme Q10, vitamin E, and selenium supplementation to psoriasis patients.Nutrition. 2009; 25: 295-302
- Administration of inositol to a patient with bipolar disorder and psoriasis: a case report.Cases J. 2010; 3: 69
- The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial.Br J Dermatol. 2004; 150: 966-969
- Abnormal serum copper and zinc levels in patients with psoriasis: a meta-analysis.Indian J Dermatol. 2019; 64: 224-230
- A trial of oral zinc supplementation in psoriasis.Cutis. 1994; 54: 117-118
- Treatment of localized psoriasis with a topical formulation of zinc pyrithione.Acta Dermatovenerol Alp Pannonica Adriat. 2011; 20: 187-190
Article info
Publication history
Published online: October 26, 2021
Footnotes
IRB Approval Status: Not applicable
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