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Anogenital involvement: Clinical sign of severity in hidradenitis suppurativa

      Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle characterized by painful, deep-seated, inflamed lesions in the apocrine gland-bearing regions.
      • Zouboulis CC
      • Desai N
      • Emtestam L
      • et al.
      European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.
      ,
      • Reddy S
      • Strunk A
      • Garg A.
      Comparative overall comorbidity burden among patients with hidradenitis suppurativa.
      Patients with HS have a higher comorbidity burden and a worse quality of life (QoL) compared with patients affected by other skin diseases.
      • Goldburg SR
      • Strober BE
      • Payette MJ.
      Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.
      • Hamad J
      • McCormick BJ
      • Sayed CJ
      • et al.
      Multidisciplinary update on genital hidradenitis suppurativa: A review.
      • Fania L
      • Caggiati A
      • Laporta R
      • et al.
      Severe forms of hidradenitis suppurativa with complications in the anogenital area.
      Anogenital involvement is associated with a high risk of complications, including local scarring, anal/perianal fistulas, lymphedema, penile degloving, squamous cell carcinoma, and the lack of efficacy for common systemic therapy.
      • Hamad J
      • McCormick BJ
      • Sayed CJ
      • et al.
      Multidisciplinary update on genital hidradenitis suppurativa: A review.
      ,
      • Fania L
      • Caggiati A
      • Laporta R
      • et al.
      Severe forms of hidradenitis suppurativa with complications in the anogenital area.
      This brings a worse impact on QoL due to pain, secretions, and mobility issues.
      • Hamad J
      • McCormick BJ
      • Sayed CJ
      • et al.
      Multidisciplinary update on genital hidradenitis suppurativa: A review.
      ,
      • Fania L
      • Caggiati A
      • Laporta R
      • et al.
      Severe forms of hidradenitis suppurativa with complications in the anogenital area.
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      References

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        • Desai N
        • Emtestam L
        • et al.
        European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa.
        J Eur Acad Dermatol Venereol. 2015; 29: 619-644
        • Reddy S
        • Strunk A
        • Garg A.
        Comparative overall comorbidity burden among patients with hidradenitis suppurativa.
        JAMA Dermatol. 2019; 155: 797-802
        • Goldburg SR
        • Strober BE
        • Payette MJ.
        Hidradenitis suppurativa: Epidemiology, clinical presentation, and pathogenesis.
        J Am Acad Dermatol. 2020; 82: 1045-1058
        • Hamad J
        • McCormick BJ
        • Sayed CJ
        • et al.
        Multidisciplinary update on genital hidradenitis suppurativa: A review.
        JAMA Surg. 2020; 155: 970-977
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        • Laporta R
        • et al.
        Severe forms of hidradenitis suppurativa with complications in the anogenital area.
        Dermatol Ther. 2019; 32: e12910