Abstract
The list of comorbidities and complications associated with hidradenitis suppurativa
is extensive. Among the complications of hidradenitis suppurativa, squamous cell carcinoma
is considered the most severe. After a meticulous literature research starting from
the 1950s, we were able to identify over 90 cases of patients with hidradenitis suppurativa
developing squamous cell carcinoma. Most squamous cell carcinomas appear on the perineal
or buttock areas. We believe that the development of squamous cell carcinoma in longstanding
hidradenitis suppurativa is a typical condition of an immunocompromised district.
The “immunocompromised cutaneous district” is a novel concept that applies to an area
of diseased or injured skin where local immune control has been altered, thereby permitting
the development of a dysimmune reaction, infection, or tumor confined to the diseased
or injured site.
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© 2016 Published by Elsevier Inc.
