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Lobomycosis

      Abstract

      Lobomycosis is a rare chronic fungal infection of the subcutaneous tissue found in South America, mainly in Brazil. It is caused by Lacazia loboi. Its clinical manifestations are dermal nodules, either lenticular or in plaques, and keloidlike lesions that can resemble nodular leprosy or leishmaniasis, other subcutaneous mycoses (sporotrychosis, chromomycosis, paracoccidioidomycosis), keloids, and malignant tumors. Diagnosis is made by the histopathological findings of the fungus. For treatment, surgical removal of the lesions, followed by itraconazole and clofazimine for disseminated lesions, has been used with variable results.
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      References

        • Lobo J.O.
        Nova especie de blastomicose.
        Brasil Med. 1930; 44: 1227
        • Lobo J.O.
        Um caso de blastomycose producido por uma espécie nova, encontrada en Recife.
        Rev Med Pernambuco. 1931; 1: 763-765
        • Baruzzi R.G.
        • Lacaz de S.
        • Souza P.A.
        Historia natural de doença de Jorge Lobo; ocurrencia entre os indios Caiabi (Brasil Central).
        Rev Med Trop Sao Paulo. 1979; 21: 302-338
        • Cardoso de Brito A.
        • Simões Quaresma J.A.
        Lacaziosis (Jorge Lobo's disease): review and update.
        An Bras Dermatol. 2007; 82: 461-474
        • Rodríguez-Toro G.
        • Téllez N.
        Lobomycosis in Colombian Amerindian patients.
        Micopathologia. 1992; 120: 5-9
        • Paniz-Mondolfi A.E.
        • Reyes-Jaimes O.
        • Dávila-Jones L.
        Lobomycosis in Venezuela.
        Int J Dermatol. 2007; 46: 180-185
        • Rodríguez-Toro G.
        Lobomycosis.
        Int J Dermatol. 1993; 35: 324-332
        • Burns R.A.
        • Roy J.S.
        • Woods C.
        • Padhye A.A.
        • Warnock D.W.
        Report of the first human case of lobomycosis in the United States.
        J Clin Microbiol. 2000; 38: 1283-1285
        • Elsayed S.
        • Kuhn S.M.
        • Barber D.
        • Church D.L.
        • Adams S.
        • Kasper R.
        Human case of lobomycosis.
        Emerg Infect Dis. 2004; 10: 715-718
        • Al-Daraji W.I.
        • Husain E.
        • Robson A.
        Lobomycosis in African patients.
        Br J Dermatol. 2008; 159: 234-236
        • Fonseca O.F.
        • Leão A.E.
        Contribuição para o conhecimento das granulomatoses blastomycoides. O agente etiologico da doença de Jorge Lobo.
        Rev Med Cir Bras. 1940; 48: 147-158
        • Borelli D.
        Lobomicose: nomenclatura de su agente (revisión critica).
        Med Cutanea. 1968; 3: 151-156
        • Taborda P.R.
        • Taborda V.A.
        • McGinnis M.R.
        Lacazia loboi General Nov, comb. Nov, the etiologic agent of Lobomycosis.
        J Clin Microbiol. 1999; 37: 2031-2033
        • Migaki G.
        • Valerio M.G.
        • Irvine B.
        • et al.
        Lobo's disease in an Atlantic bottle-nosed dolphin.
        J Am Vet Med Assoc. 1971; 159: 582
        • Caldwell D.K.
        • Caldwell M.C.
        • Woodard J.C.
        • Ajello L.
        • Kaplan W.
        • McLure H.M.
        Lobomycosis as a disease of the Atlantic bottle-nosed dolphin (Tursiops truncatus Montagu, 1821).
        Am J Trop Med Hyg. 1975; 24: 105-114
        • Paniz Mondolfi A.E.
        • Sander-Hoffmann L.
        Lobomycosis in inshore and estuarine dolphins.
        Emerg Infect Dis. 2009; 15: 672-673
        • Symmers WStC
        A possible case of Lobo's disease acquired in Europe from a bottle-nosed dolphin (Tursiops truncatus).
        Bull Soc Pathol Exot. 1983; 76: 777-784
        • Rotstein D.S.
        • Burdett L.G.
        • McLellan W.
        • et al.
        Lobomycosis in offshore bottlenose dolphins (Tursiops truncatus), North Carolina.
        Emerg Infect Dis. 2009; 15: 588-590
      1. Pradinaud R. Lobomycose (Maladie de Jorge Lobo). In: Encycl Medical Chir, Maladies Infectieuses. Paris; 1977. pp. 8126 A 10:1-6.

        • Vilani-Moreno F.R.
        • Belone A.F.
        • Soares C.T.
        • Opromolla D.V.A.
        Immunohistochemical characterization of the cellular infiltrate in Jorge Lobo's disease.
        Rev Iberoam Micol. 2005; 22: 44-49
        • Talhari S.
        Enfermedad de Jorge Lobo.
        Arch Argent Dermatol. 1981; 31: 23-26
        • Azulay R.D.
        • Carneiro J.A.
        • Cunha M.G.S.
        • Reis L.T.
        Keloidal blastomycosis (Lobo's disease) with lymphatic involvement: a case report.
        Int J Dermatol. 1976; 15: 40-42
        • Opromolla D.V.A.
        • Belone A.F.F.
        • Taborda P.R.
        • Rosa P.S.
        Lymph node involvement in Jorge Lobo's disease: report of two cases.
        Int J Dermatol. 2003; 42: 938-941
        • Talhari C.
        • Oliveira C.B.
        • de Souza Santos M.N.
        • Ferreira L.C.
        • Talhari S.
        Disseminated lobomycosis.
        Int J Dermatol. 2008; 47: 582-583
        • Pradinaud R.
        Loboa loboi.
        in: Collier L. Balows A. Sussman M. Topley and Wilson's microbiology and microbial infections. Oxford University Press, New York1998: 585-594
        • Rodriguez-Toro G.
        Enfermedad de Jorge Lobo o blastomicosis queloidiana. Nuevos aspectos de la entidad en Colombia.
        Revisión Biomédica (Bogota). 1989; 9: 133-146
        • Baruzzi R.
        • Rodrigues D.
        • Michalany N.
        • et al.
        Squamous-cell carcinoma and Lobomycosis.
        Int J Derm. 1989; 28: 183-185
        • Miranda M.F.
        • Silva A.J.
        Vinyl adhesive tape also effective for direct microscopy diagnosis of chromomycosis, lobomycosis, and paracoccidioidomycosis.
        Diagn Microbiol Infect Dis. 2005; 52: 39-43
        • Talhari C.
        • Chrusciak-Talhari A.
        • de Souza J.V.
        • Araújo J.R.
        • Talhari S.
        Exfoliative cytology as a rapid diagnostic tool for lobomycosis.
        Mycoses. 2009; 52: 187-189
        • Rodriguez G.
        • Barrera G.P.
        The asteroid body of lobomycosis.
        Mycopathologia. 1996-1997; 136: 71-74
        • Carneiro F.P.
        • Maia L.B.
        • Moraes M.A.
        • et al.
        Lobomycosis: diagnosis and management of relapsed and multifocal lesions.
        Diagn Microbiol Infect Dis. 2009; 65: 62-64
        • Londoño F.
        Blastomicosis queloidiana. A propósito de un caso tratado con anfotericina B.
        Med Cutan Ibero Lat Am. 1968; 2: 521-524
        • Reyes O.
        • Goihman M.
        • Goldstein C.
        Blastomicosis queloidiana o enfermedad de Jorge Lobo. Comunicación previa sobre un caso observado.
        Derm Venez. 1960; 2: 245-255
      2. Pradinaud R, Talhari S. Lobomycose. In: Encycl Med Chir, Paris, Maladies Infectieuses, Paris. 1996;608A10:1-6.

        • Fischer M.
        • Talhari A.C.
        • Reinel D.
        • Talhari S.
        Lobomykose.
        Hautarzt. 2002; 53: 677-681
        • Dudok Van Heel W.H.
        Successful treatment in a case of lobomycosis (Lobo’s disease) in Tursiops truncatus at the Dolphinarium, Harderwijk.
        Aquatic Mammals. 1977; 5: 8-15
        • Bustamante B.
        Posaconazole therapy for lobomycosis: preliminary report of a Peruvian case. P-0199.
        in: Paper presented at: The 16th Congress of the International Society for Human and Animal Mycology; June 25-29; Paris, France2006