Abstract
The skin is a vital organ for life and, among its many functions, the role as a protective
barrier is one of the most important. It is the main boundary between the body and
the external environment. As defensive barrier, the epidermis protects internal organs
from physical and chemical trauma, microorganism invasion, and ultraviolet radiation.
It also acts in the regulation of transepidermal movement of water and electrolytes,
and in preventing dehydration, all of which are essential for sustaining life. The
main role is allotted to the stratum corneum and to the lipid matrix located in the
intercellular space. The occurrence of dysfunction in the epidermal barrier is an
important factor in the physiopathogenesis of skin diseases, particularly atopic dermatitis
and psoriasis. There are few, but important, systemic changes that influence or are
influenced by dysfunctions in the epidermal barrier. We review the effects of some
systemic diseases on the maintenance of the skin's homeostasis.
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References
- An update of the defensive barrier function of skin.Yonsei Med J. 2006; 47: 293-306
- Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs. passive mechanisms.J Invest Dermatol. 2002; 119: 1269-1274
- Delayed restoration of epidermal barrier function after blister injury in patients with diabetes mellitus.Diabet Med. 1999; 16: 563-567
- Depletion of stratum corneum intercellular lipid lamellae and barrier function abnormalities after long-term topical corticosteroids.Br J Dermatol. 1997; 136: 884-890
- Permeability barrier abnormality of hairless mouse epidermis after topical corticosteroid: characterization of stratum corneum lipids by ruthenium tetroxide staining and high-performance thin-layer chromatography.J Dermatol. 1998; 25: 281-289
- Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities.J Invest Dermatol. 2003; 120: 456-464
- Chronic life stress alters sympathetic, neuroendocrine, and immune responsivity to an acute psychological stressor in humans.Psychosom Med. 1997; 59: 447-457
- Hormonal responses to psychological stress in men preparing for skydiving.J Clin Endocrinol Metab. 1997; 82: 2503-2509
- Stress alters cutaneous permeability barrier homeostasis.Am J Physiol Regul Integr Comp Physiol. 2000; 278: R367-R372
- Psychological stress perturbs epidermal permeability barrier homeostasis.Arch Dermatol. 2001; 137: 53-59
- A nervous breakdown in the skin: stress and the epidermal barrier.J Clin Invest. 2007; 117: 3166-3169
- Prevalence and factors associated with dry skin in HIV infection: the FRAM study.AIDS. 2007; 21: 2051-2057
- Epidermal barrier dysfunction in non-atopic HIV: evidence for an “inside-to-outside” pathogenesis.J Invest Dermatol. 2010; 130: 1185-1188
- Obesity resistance of the stearoyl-CoA desaturase-deficient (scd1–/–) mouse results from disruption of the epidermal lipid barrier and adaptive thermoregulation.Biol Chem. 2007; 388: 405-418
- Paradoxical effects of beta-estradiol on epidermal permeability barrier homeostasis.Br J Dermatol. 2007; 157: 776-779
- Testosterone perturbs epidermal permeability barrier homeostasis.J Invest Dermatol. 2001; 116: 443-451
Article info
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© 2012 Published by Elsevier Inc.
