Abstract
Skin health depends on an intact barrier composed of protein-rich corneocytes surrounded
by the lamellar intercellular lipids. This barrier provides waterproof protection
for the body, preventing infection, regulating electrolyte balance, maintaining body
temperature, and providing a mechanism for sensation. Damage to the skin barrier results
in skin disease that can be treated by a variety of externally applied substances,
such as ceramides, hyaluronic acid, licorice extracts, dimethicone, petrolatum, and
paraffin wax. These substances are found in moisturizers that are sold as cosmetics
and in prescriptions as 510(k) devices. This contribution examines the formulation
and effect of skin barrier creams.
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© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
