Abstract
The skin is the organ that acts as a barrier between the outer and inner environments
of the body. It is thus exposed not only to a wide variety of physical, chemical,
and thermal insults from the outside world but also to inner endogenous stimuli. Stress,
once an abstract psychologic phenomenon, has taken research's center stage in recent
years. The “mind–body connection” is now less of an obscure New Age term and more
of an elaborate physiologic pathway by which bilateral communication occurs between
body and brain. Dermatologists and dermatologic patients have long acknowledged the
effect of stress on the skin and its capability to initiate, maintain, or exacerbate
several skin diseases. Because disruption of epidermal barrier integrity may be important
in the development of some common skin diseases, it is crucial to understand its vulnerability
to psychologic stress.
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