Abstract
The effect of sugars on aging skin is governed by the simple act of covalently cross-linking
two collagen fibers, which renders both of them incapable of easy repair. Glucose
and fructose link the amino acids present in the collagen and elastin that support
the dermis, producing advanced glycation end products or “AGEs.” This process is accelerated
in all body tissues when sugar is elevated and is further stimulated by ultraviolet
light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous
tissues is being defined, as are methods of reducing the glycation load through careful
diet and use of supplements.
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