Abstract
The focus of this contribution is oxidation generated by oxygen and by all other reactive
species, with an emphasis on reactive oxygen species. This study considers the different
pathways that generate oxidative stress, which is a physiologic process that can become
dangerous if becomes excessive and overcomes the reserve of antioxidants. Some of
the most important methods to determine oxidative stress in plasma, both in humans
and in experimental animals, are discussed; particular attention is given to the d-ROMs
test, which detects the hydroperoxides in plasma and is a very simple and reliable
method. The antioxidant hierarchy also is discussed to indicate the most powerful
physiological antioxidant and those derived from food intake or supplementation. As
every antioxidant also can be a pro-oxidant, indications are given about their use
and how to avoid the administration of high dosages of a single antioxidant.
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Article info
Footnotes
The author has no interests in any of the methods used to determine oxidative stress. The author is an executive manager of a company that develops antioxidants for the European Market.
Identification
Copyright
© 2009 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
