Abstract
Wound healing is a complex process that can be divided into at least 3 continuous
and overlapping processes: an inflammatory reaction, a proliferative process leading
to tissue restoration, and, eventually, tissue remodeling. Wound healing processes
are strictly regulated by multiple growth factors and cytokines released at the wound
site. Although the desirable final result of coordinated healing would be the formation
of tissue with a similar structure and comparable functions as with intact skin, regeneration
is uncommon (with notable exceptions such as early fetal healing); healing however
results in a structurally and functionally satisfactory but not identical outcome.
Alterations that disrupt controlled healing processes would extend tissue damage and
repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive
fibrosis.
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© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
