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Research Article| Volume 24, ISSUE 4, P317-325, July 2006

Comparative dermatology—canine endocrine dermatoses

      Abstract

      Endocrine diseases in the dog commonly manifest with dermatological lesions. Hypothyroidism is the most common endocrinopathy and usually presents with alopecia in areas of wear, seborrhea, and recurrent infections. Common clinical signs associated with hyperadrenocorticism include polyuria, polydipsia, and polyphagia. The most common dermatological manifestation of hyperadrenocorticism is bilaterally symmetrical alopecia sparing the head and distal extremities. Pyoderma is a common finding associated with immunosuppression. Less commonly, calcinosus cutis may occur. Sex hormone excess, primarily hyperestrogenism and hyperandrogenism, may also be associated with dermatological signs. Usually, dogs are intact, and the excess production is due to testicular or ovarian neoplasia.
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      References

        • Feldman E.C.
        • Nelson R.W.
        Canine and feline endocrinology and reproduction. 3rd ed. W.B. Saunders, St. Louis (MO)2004: 86-151
        • Muller G.H.
        • Kirk R.W.
        • Scott D.W.
        • et al.
        Muller and Kirk's small animal dermatology. 6th ed. W.B. Saunders, Philadelphia2001: 780-885
        • Scott-Moncrieff J.C.
        • Azcona-Olivera J.
        • Glickman N.W.
        • et al.
        Evaluation of antithyroglobulin antibodies after routine vaccination in pet and research dogs.
        J Am Vet Med Assoc. 2002; 221: 515-521
        • Breyer U.
        • Reese S.
        • Deeg C.
        • et al.
        Diagnostische und pradiktive Wertigkeit von thyreoglobulinspezifischen Autoantikorpern (TgAAk) beim Hund.
        Tierarztl Prax. 2004; 32: 207-213
        • Greco D.S.
        • Feldman E.C.
        • Peterson M.E.
        • et al.
        Congenital hypothyroid dwarfism in a family of giant schnauzers.
        J Vet Intern Med. 1991; 5: 57-65
        • Mooney C.T.
        • Anderson T.J.
        Congenital hypothyroidism in a boxer dog.
        J Small Anim Pract. 1993; 34: 31-35
        • Torres S.M.
        • McKeever P.J.
        • Johnston S.D.
        Effect of oral administration of prednisolone on thyroid function in dogs.
        Am J Vet Res. 1991; 52: 416-421
        • Kaptein E.M.
        • Moore G.E.
        • Ferguson D.C.
        • et al.
        Effects of prednisone on thyroxine and 3,5,3′-triiodothyronine metabolism in normal dogs.
        Endocrinology. 1992; 130: 1669-1679
        • Ferguson D.C.
        • Peterson M.E.
        Serum free and total iodothyronine concentrations in dogs with hyperadrenocorticism.
        Am J Vet Res. 1992; 53: 1636-1640
        • Panciera D.L.
        Hypothyroidism in dogs: 66 cases (1987-1992).
        J Am Vet Med Assoc. 1994; 204: 761-767
        • Panciera D.L.
        An echocardiographic and electrocardiographic study of cardiovascular function in hypothyroid dogs.
        J Am Vet Med Assoc. 1994; 205: 996-1000
        • Bichsel P.
        • Jacobs G.
        • Oliver Jr, J.E.
        Neurologic manifestations associated with hypothyroidism in four dogs.
        J Am Vet Med Assoc. 1988; 192: 1745-1747
        • Jaggy A.
        • Oliver J.E.
        • Ferguson D.C.
        • et al.
        Neurological manifestations of hypothyroidism: a retrospective study of 29 dogs.
        J Vet Intern Med. 1994; 8: 328-336
        • Indrieri R.J.
        • Whalen L.R.
        • Cardinet G.H.
        • et al.
        Neuromuscular abnormalities associated with hypothyroidism and lymphocytic thyroiditis in three dogs.
        J Am Vet Med Assoc. 1987; 190: 544-548
        • Budsberg S.C.
        • Moore G.E.
        • Klappenbach K.
        Thyroxine-responsive unilateral forelimb lameness and generalized neuromuscular disease in four hypothyroid dogs.
        J Am Vet Med Assoc. 1993; 202: 1859-1860
        • Fatjo J.
        • Stub C.
        • Manteca X.
        Four cases of aggression and hypothyroidism in dogs.
        Vet Rec. 2002; 151: 547-548
      1. Henik RA, Dixon RM, Intravenous administration of levothyroxine for treatment of suspected myxedema coma complicated by severe hypothermia in a dog. J Am Vet Med Assoc 2000;216:713-717, 685.

        • Credille K.M.
        • Slater M.R.
        • Moriello K.A.
        • et al.
        The effects of thyroid hormones on the skin of beagle dogs.
        J Vet Intern Med. 2001; 15: 539-546
        • Daminet S.
        • Ferguson D.C.
        Influence of drugs on thyroid function in dogs.
        J Vet Intern Med. 2003; 17: 463-472
        • Frank L.A.
        • Hnilica K.A.
        • May E.R.
        • et al.
        Effects of sulfamethoxazole-trimethoprim on thyroid function in dogs.
        Am J Vet Res. 2005; 66: 256-259
        • Torres S.M.
        • Feeney D.A.
        • Lekcharoensuk C.
        • et al.
        Comparison of colloid, thyroid follicular epithelium, and thyroid hormone concentrations in healthy and severely sick dogs.
        J Am Vet Med Assoc. 2003; 222: 1079-1085
        • Yilmaz Z.
        • Golcu E.
        • Yalcin E.
        • et al.
        T3, T4 and TSH concentrations in dogs with non-thyroidal illness.
        Indian Vet J. 2003; 80: 49-51
        • Peterson M.E.
        • Melian C.
        • Nichols R.
        Measurement of serum total thyroxine, triiodothyronine, free thyroxine, and thyrotropin concentrations for diagnosis of hypothyroidism in dogs.
        J Am Vet Med Assoc. 1997; 211: 1396-1402
        • Scott-Moncrieff J.C.
        • Nelson R.W.
        • Bruner J.M.
        • et al.
        Comparison of serum concentrations of thyroid-stimulating hormone in healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease.
        J Am Vet Med Assoc. 1998; 212: 387-391
        • Dixon R.M.
        • Mooney C.T.
        Evaluation of serum free thyroxine and thyrotropin concentrations in the diagnosis of canine hypothyroidism.
        J Small Anim Pract. 1999; 40: 72-78
        • Schachter S.
        • Nelson R.W.
        • Scott-Moncrieff C.
        • et al.
        Comparison of serum-free thyroxine concentrations determined by standard equilibrium dialysis, modified equilibrium dialysis, and 5 radioimmunoassays in dogs.
        J Vet Intern Med. 2004; 18: 259-264
        • Dixon R.M.
        • Graham P.A.
        • Mooney C.T.
        Serum thyrotropin concentrations: a new diagnostic test for canine hypothyroidism.
        Vet Rec. 1996; 138: 594-595
        • Dixon R.M.
        • Reid S.W.
        • Mooney C.T.
        Treatment and therapeutic monitoring of canine hypothyroidism.
        J Small Anim Pract. 2002; 43: 334-340
        • Scott-Moncrieff J.C.
        • Nelson R.W.
        Change in serum thyroid-stimulating hormone concentration in response to administration of thyrotropin-releasing hormone to healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease.
        J Am Vet Med Assoc. 1998; 213: 1435-1438
        • Frank L.A.
        Comparison of thyrotropin-releasing hormone (TRH) to thyrotropin (TSH) stimulation for evaluating thyroid function in dogs.
        J Am Anim Hosp Assoc. 1996; 32: 481-487
        • Patzl M.
        • Mostl E.
        Determination of autoantibodies to thyroglobulin, thyroxine and triiodothyronine in canine serum.
        J Vet Med A Physiol Pathol Clin Med. 2003; 50: 72-78
        • Tani H.
        • Shimizu R.
        • Sasai K.
        • et al.
        Recognition pattern of thyroglobulin autoantibody from hypothyroid dogs to tryptic peptides of canine thyroglobulin.
        J Vet Med Sci. 2003; 65: 1049-1056
        • Lee J.Y.
        • Uzuka Y.
        • Tanabe S.
        • et al.
        Prevalence of thyroglobulin autoantibodies detected by enzyme-linked immunosorbent assay of canine serum in hypothyroid, obese and healthy dogs in Japan.
        Res Vet Sci. 2004; 76: 129-132
        • Dixon R.M.
        • Mooney C.T.
        Canine serum thyroglobulin autoantibodies in health, hypothyroidism and non-thyroidal illness.
        Res Vet Sci. 1999; 66: 243-246
        • Kemppainen R.J.
        • Young D.W.
        • Behrend E.N.
        • et al.
        Autoantibodies to triiodothyronine and thyroxine in a golden retriever.
        J Am Anim Hosp Assoc. 1996; 32: 195-198
        • Nachreiner R.F.
        • Refsal K.R.
        • Graham P.A.
        • et al.
        Prevalence of serum thyroid hormone autoantibodies in dogs with clinical signs of hypothyroidism.
        J Am Vet Med Assoc. 2002; 220: 466-471
        • Nachreiner R.F.
        • Refsal K.R.
        • Ravis W.R.
        • et al.
        Pharmacokinetics of l-thyroxine after its oral administration in dogs.
        Am J Vet Res. 1993; 54: 2091-2098
        • Kaptein E.M.
        • Moore G.E.
        • Ferguson D.C.
        • et al.
        Thyroxine and triiodothyronine distribution and metabolism in thyroxine-replaced athyreotic dogs and normal humans.
        Am J Physiol. 1993; 264: E90-E100
        • Greco D.S.
        • Peterson M.E.
        • Davidson A.P.
        • et al.
        Concurrent pituitary and adrenal tumors in dogs with hyperadrenocorticism: 17 cases (1978-1995).
        J Am Vet Med Assoc. 1999; 214: 1349-1353
        • Ford S.L.
        • Feldman E.C.
        • Nelson R.W.
        Hyperadrenocorticism caused by bilateral adrenocortical neoplasia in dogs: four cases (1983-1988).
        J Am Vet Med Assoc. 1993; 202: 789-792
        • Feldman E.C.
        • Nelson R.W.
        Canine and feline endocrinology and reproduction. 3rd ed. W.B. Saunders, St. Louis (MO)2004: 252-357
        • Nichols R.
        Concurrent illness and complications associated with canine hyperadrenocorticism.
        Semin Vet Med Surg (Small Anim). 1994; 9: 132-136
        • LaRue M.J.
        • Murtaugh R.J.
        Pulmonary thromboembolism in dogs: 47 cases (1986-1987).
        J Am Vet Med Assoc. 1990; 97: 1368-1372
        • Ortega T.M.
        • Feldman E.C.
        • Nelson R.W.
        • et al.
        Systemic arterial blood pressure and urine protein/creatinine ratio in dogs with hyperadrenocorticism.
        J Am Vet Med Assoc. 1996; 209: 1724-1729
        • Hess R.S.
        • Kass P.H.
        • Ward C.R.
        Association between hyperadrenocorticism and development of calcium-containing uroliths in dogs with urolithiasis.
        J Am Vet Med Assoc. 1998; 212: 1889-1891
        • Blaxter A.C.
        • Gruffydd-Jones T.J.
        Concurrent diabetes mellitus and hyperadrenocorticism in the dog: diagnosis and management of eight cases.
        J Small Anim Pract. 1990; 31: 117-122
        • Stewart L.J.
        The integumentary changes of hyperadrenocorticism.
        Semin Vet Med Surg (Small Anim). 1994; 9: 123-126
        • Mack R.E.
        • Feldman E.C.
        • Wilson S.M.
        Diagnosis of hyperadrenocorticism in dogs.
        Compend Small Anim Pract. 1994; 16: 311-329
        • Frank L.A.
        • DeNovo R.C.
        • Kraje A.C.
        • et al.
        Cortisol concentrations following stimulation of healthy and adrenopathic dogs with two doses of tetracosactrin.
        J Small Anim Pract. 2000; 41: 308-311
        • Van Liew C.H.
        • Greco D.S.
        • Salman M.D.
        Comparison of results of adrenocorticotropic hormone stimulation and low-dose dexamethasone suppression tests with necropsy findings in dogs: 81 cases (1985-1995).
        J Am Vet Med Assoc. 1997; 211: 322-325
        • May E.R.
        • Frank L.A.
        • Hnilica K.A.
        • et al.
        Effects of a mock ultrasonographic procedure on cortisol concentrations during low-dose dexamethasone suppression testing in clinically normal adult dogs.
        Am J Vet Res. 2004; 65: 267-270
        • Rijnberk A.
        • van Wees A.
        • Mol J.A.
        Assessment of two tests for the diagnosis of canine hyperadrenocorticism.
        Vet Rec. 1988; 122: 178-180
        • Ristic J.ME.
        • Ramsey I.K.
        • Heath F.M.
        • et al.
        The use of 17-hydroxyprogesterone in the diagnosis of canine hyperadrenocorticism.
        J Vet Intern Med. 2002; 16: 433-439
        • Norman E.J.
        • Thompson H.
        • Mooney C.T.
        Dynamic adrenal function testing in eight dogs with hyperadrenocorticism associated with adrenocortical neoplasia.
        Vet Rec. 1999; 144: 551-554
        • Hill K.E.
        • Scott-Moncrieff J.C.
        • Koshko M.A.
        • et al.
        Secretion of sex hormones in dogs with adrenal dysfunction.
        J Am Vet Med Assoc. 2005; 226: 556-561
        • Reusch C.E.
        • Feldman E.C.
        Canine hyperadrenocorticism due to adrenocortical neoplasia.
        J Vet Intern Med. 1991; 5: 3-10
        • Plotnick A.
        Diagnosing canine hyperadrenocorticism: keeping things simple.
        Vet Forum. 2004; : 34-41
        • Peterson M.E.
        • Kintzer P.P.
        Medical treatment of pituitary-dependent hyperadrenocorticism. Mitotane.
        Vet Clin North Am Small Anim Pract. 1997; 27: 255-272
        • den Hertog E.
        • Braakman J.C.
        • Teske E.
        • et al.
        Results of non-selective adrenocorticolysis by o,p'-DDD in 129 dogs with pituitary-dependent hyperadrenocorticism.
        Vet Rec. 1999; 144: 12-17
        • Sennello K.A.
        • Panciera D.L.
        • Lanz O.I.
        • et al.
        Treating adrenal neoplasia in dogs and cats.
        Vet Med. 2004; : 172-186
        • Ruckstuhl N.S.
        • Nett C.S.
        • Reusch C.E.
        Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane.
        Am J Vet Res. 2002; 63: 506-512
        • Braddock J.A.
        • Church D.B.
        • Robertson I.D.
        • et al.
        Trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism.
        Aust Vet J. 2003; 81: 600-607
        • Chapman P.S.
        • Kelly D.F.
        • Archer J.
        • et al.
        Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism.
        J Small Anim Pract. 2004; 45: 307-310
        • Reusch C.E.
        • Steffen T.
        • Hoerauf A.
        The efficacy of l-deprenyl in dogs with pituitary-dependent hyperadrenocorticism.
        J Vet Intern Med. 1999; 13: 291-301
        • Braddock J.A.
        • Church D.B.
        • Robertson I.D.
        • et al.
        Inefficacy of selegiline in treatment of canine pituitary-dependent hyperadrenocorticism.
        Aust Vet J. 2004; 82: 272-277
        • Melby J.C.
        Therapy of Cushing disease: a consensus for pituitary microsurgery.
        Ann Intern Med. 1988; 109: 445-446
        • Axlund T.W.
        • Behrend E.N.
        • Winkler J.T.
        Surgical treatment of canine hyperadrenocorticism.
        Compend Small Anim/Exot. 2003; 25: 334-347
        • Anderson C.R.
        • Birchard S.J.
        • Powers B.E.
        • et al.
        Surgical treatment of adrenocortical tumors: 21 cases (1990-1996).
        J Am Anim Hosp Assoc. 2001; 37: 93-97
        • Suess Jr, R.P.
        • Barr S.C.
        • Sacre B.J.
        • et al.
        Bone marrow hypoplasia in a feminized dog with an interstitial cell tumor.
        J Am Vet Med Assoc. 1992; 200: 1346-1348
        • Barsanti J.A.
        • Medleau L.
        • Latimer K.
        Diethylstilbestrol-induced alopecia in a dog.
        J Am Vet Med Assoc. 1983; 182: 63-64
        • Peters M.A.
        • de Jong F.H.
        • Teerds K.J.
        • et al.
        Ageing, testicular tumours and the pituitary-testis axis in dogs.
        J Endocrinol. 2000; 166: 153-161
        • Medleau L.
        Sex hormone–associated endocrine alopecias in dogs.
        J Am Anim Hosp Assoc. 1989; 25: 689-694
        • Nemzek J.A.
        • Homco L.D.
        • Wheaton L.G.
        • et al.
        Cystic ovaries and hyperestrogenism in a canine female pseudohermaphrodite.
        J Am Anim Hosp Assoc. 1992; 28: 402-406
        • Rosychuk R.A.W.
        Cutaneous manifestations of endocrine disease in dogs.
        Compend Small Anim Pract. 1998; 20: 287-302
        • Frank L.A.
        Sex hormone dermatoses.
        Small Anim Dermatol Secrets. 2004; : 280-288
      2. Syme HM, Scott-Moncrieff JC, Treadwell NG, et al. Hyperadrenocorticism associated with excessive sex hormone production by an adrenocortical tumor in two dogs. J Am Vet Med Assoc 2001;219:1725-8, 1707-8.