Pemphigus is an autoimmune disease characterized by acantholysis and subsequent blistering
of the skin and oral mucosa, mediated by autoantibodies directed against intercellular
antigens desmoglein-3 and desmoglein-1.
1
The primary stimulus for this autoimmune response was unknown until Degos et al
2
demonstrated pemphigus induced by external factors, namely by a drug. Today it is
well known that pemphigus develops as a result of the interaction between endogenous
(genetic) factors
3
,
4
and exogenous factors.To read this article in full you will need to make a payment
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© 2002 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
