Borrelia burgdorferi (B. burgdorferi), a spirochete mostly transmitted by ticks of the Ixodidae family, causes Lyme borreliosis (LB), a multisystemic disease that affects the skin,
joints, central nervous system, and heart.
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Typical and the most common skin manifestation of Lyme borreliosis is erythema migrans
(EM), whereas neurologic symptoms, joint involvement, and chronic skin alterations
can develop at later stages of the disease.
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References
- Lyme disease.Science. 1982; 216: 1317-1319
- Discovery of the Lyme disease spirochete and its relationship to tick vectors.Yale J Biol Med. 1984; 57 (515–520): 71-76
- Lyme bolest.in: Lipozenc̆ić J Dermatovenerologija. Naklada Zadro, Zagreb1999: 101-103
- Epidemiologic, ecologic and clinical characteristics of Lyme borreliosis in Northwest Croatia.Acta Med Croat. 1998; 52: 7-13
- Genetic and phenotypic analysis of Borrelia valaisiana sp. nov. (Borrelia genomic groups VS116 and M19).Int J Syst Bacteriol. 1997; 47: 926-932
- First isolation of Borrelia burgdorferi sensu lato in Croatia.Acta Dermatovenerol Croat. 1997; 5: 95-99
- Detection and genotyping of Borrelia burgdorferi sensu lato by polymerase chain reaction.Croat Med J. 2000; 41: 47-53
- Cross-reactivity in serological tests for Lyme disease and other spirochetal infections.J Infect Dis. 1987; 156: 183-188
- Laboratory tests for Lyme disease.Dermatol Clin. 1994; 12: 19-24
- Diagnosing early Lyme disease.Am J Med. 1985; 78: 233-240
- The laboratory diagnosis of Lyme disease.Arch Dermatol. 1991; 127: 866-870
- Diagnostic value of PCR for detection of Borrelia burgdorferi DNA in clinical specimens from patients with erythema migrans and Lyme borreliosis.Mol Diagn. 2000; 5: 139-150
- Detection of Borrelia burgdorferi using the polymerase chain reaction.J Clin Microbiol. 1990; 28: 1089-1093
- Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.Science. 1988; 239: 487-491
- Bloodstream invasion in early Lyme disease.Am J Med. 1995; 99: 6-12
- Evaluation of the polymerase chain reaction for the detection of Borrelia burgdorferi in cerebrospinal fluid of children with acute peripheral facial palsy.Eur J Pediatr. 1995; 154: 374-377
- Comparison of two methods for detecting intrathecal synthesis of Borrelia burgdorferi-specific antibodies and PCR for diagnosis of Lyme neuroborreliosis.J Clin Microbiol. 1994; 32: 1795-1798
- No detection of Borrelia burgdorferi-specific DNA in erythema migrans lesion after minocycline treatment.Arch Dermatol. 1995; 131: 678-682
- Molecular typing of Borrelia burgdorferi sensu lato by PCR-restriction fragment length polymorphism analysis.J Clin Microbiol. 1995; 33: 589-595
- Is morphea caused by Borrelia burgdorferi?.Br J Dermatol. 2000; 142: 636-644
- Evidence for Borrelia burgdorferi in morphea and lichen sclerosus.Int J Dermatol. 2000; 39: 278-283
- Immunological and molecular polymorphism of OspC and immunodominant major outer surface protein of Borrelia burgdorferi.Infect Immun. 1993; 61: 2182-2191
- Individualisation of two new genomic groups among America Borrelia burgdorferi sensu lato strains.FEBS Microbiol Lett. 1994; 121: 93-98
- Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphism.Proc Natl Acad Sci USA. 1989; 86: 2766-2770
- Non-radioactive single strand conformation polymorphism (SSCP) using the Pharmacia ‘PhastSystem’.Nucleic Acids Res. 1991; 19: 3154
- Low seroprevalence of Lyme borreliosis in the mountainous area of Gorski Kotar, Croatia.Croat Med J. 2000; 41: 433-436
- Diagnosis and transmission of Lyme borreliosis.Dissertation. Universität Utrecht, Utrecht1995
- Lyme disease.N Engl J Med. 1989; 321: 586-596
- Lyme borelioza u Sloveniji.in: Ropac D Lyme borelioza u Jugoslaviji. Zbornik MAH, Zagreb1989: 93-100
- Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea.Arch Dermatol. 1995; 131: 673-677
- Cutaneous manifestations of Lyme Borreliosis in Europe.J Spiroch Tick-Borne Dis. 1994; 1: 57-60
- Borrelia burgdorferi and different types of morphea.Dermatologica. 1991; 182: 145-154
- Is localized scleroderma a Borrelia infection?.Lancet. 1985; 2: 278
- Localized scleroderma associated with Borrelia burgdorferi infection.J Am Acad Dermatol. 1993; 29: 190-196
- Prevalenz der Lyme-Borreliose in einer Schweizerischen Risiko-Population.Schweiz Med Wochenschr. 1988; 118: 65-69
- Antibodies to Borrelia burgdorferi in various population groups in Croatia.Scand J Infect Dis. 1992; 24: 683-684
- Borrelia burgdorferi infection in UK workers at risk of tick bites.Lancet. 1989; 1: 790
- Enzyme linked immunosorbent assay and indirect immunofluorescent assay for Lyme disease.J Infect Dis. 1984; 149: 465-470
- Diagnosis of early Lyme disease.Am J Med. 1985; 78: 235-240
- Erythema chronicum migrans.Dermatologica. 1987; 174: 144-149
- Cellular immune findings in Lyme disease.Am J Med. 1984; 77: 625-632
- The prevalence and incidence of clinical and asymptomatic Lyme borreliosis in a population at risk.J Infect Dis. 1991; 163: 305-310
- Lyme disease.Lancet. 1989; 1: 484-486
- Borrelia burgdorferi infection in UK workers at risk of tick bites.Lancet. 1989; 1: 789
- Antigens of Borrelia burgdorferi recognized during Lyme disease.J Clin Invest. 1986; 78: 934-939
- Immunodiagnosis of Lyme borreliosis.Rheum Dis North Am. 1989; 15: 727-734
- Comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparations for diagnosing early Lyme disease.J Infect Dis. 1988; 157: 790-797
- Seronegative Lyme disease.N Engl J Med. 1988; 319: 1441-1446
- Laboratory aspects of Lyme borreliosis.Clin Microbiol Rev. 1988; 1: 399-414
- Serological diagnosis of erythema chronicum migrans disease and related disorders.Infection. 1984; 12: 331-337
- Zum Erweiterten Spektrum zeckenubertragener Spirochätosen.Hautarzt. 1986; 37: 597-602
- Antibodies to Borrelia burgdorferi and localized scleroderma.Lancet. 1987; 1: 682
- Absence of Borrelia burgdorferi in patients with localized scleroderma (morphea).J Am Acad Dermatol. 1995; 33: 682-685
- Diagnosis of Lyme disease.Mayo Clin Proc. 1988; 63: 1116-1121
- Lyme disease surveillance in the United States, 1983–1986.Rev Infect Dis. 1989; 11: S1435-S1441
- Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay.J Clin Microbiol. 1989; 27: 545-551
- Detection of Borrelia burgdorferi sensu lato ticks.Zentralbl Bacteriol. 1998; 287: 205-210
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