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Research Article| Volume 19, ISSUE 4, P452-459, July 2001

Sunscreens

      For twenty-five centuries fair skin was considered to be an essential component of beauty in the Northern Hemisphere. From ancient times through eras of aristocracies of the early 20th century, men and women of wealth and fashion carefully protected themselves from exposure to sunlight. White skin was considered ideal, beautiful, and desirable, while tanned skin was a social stigma that pointed a finger at members of society who were obliged to do manual labor. The pale, untanned complexion even became a symbol of affluence, indicating that its owner could “afford” to stay indoors.
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      References

        • Hollubar K
        • Schmidt C
        Historical, anthropological, and biological aspects of sun and the skin.
        Clin Dermatol. 1998; 16: 19-22
        • Wilkinson J
        • Moore R
        Sunscreen, suntan and anti-sunburn preparations.
        in: Wilkinson J Moore F Harry’s cosmeticology. 7th ed. Longman Scientific & Technical, London1982: 222-263
        • Mackie B
        • Mackie L
        The PABA story.
        Australas J Dermatol. 1999; 40: 51-53
        • Pathak M
        • Robins P
        A response to concerns about sunscreens.
        J Dermatol Surg Oncol. 1989; 15: 486-487
        • Loeppky R
        • Hastings R
        • Sandbothe J
        • et al.
        Nitrosation of tertiary aromatic amines related to sunscreen ingredients.
        IRAC Sci Publ. 1991; 105: 244-252
        • Dunkel V
        • San R
        • Harbell J
        • Seifried H
        • Cameron T
        Evaluation of the mutagenicity of an N-nitroso contaminant of the sunscreen Padimate O.
        Environ Mol Mutagen. 1992; 20: 188-198
      1. Fairhurst D, Mitchnick M. Particulate sun blocks: general principles. In: Lowe N, Shaath N, Pathak M, editors. Sunscreens, development, evaluation, and regulatory aspects. 2nd ed. New York: Marcel Dekker, 1997:313–52.

        • Sayre R
        • Kollias N
        • Roberts R
        • Baqer A
        • Sadiq I
        Physical sunscreens.
        J Soc Cosmet Chem. 1990; 41: 103-109
        • Mitchnick M
        • Fairhurst D
        • Pinnell S
        Microfine zinc oxide (Z-Cote) as a photostable UVA/UVB sunblock agent.
        J Am Acad Dermatol. 1999; 40: 85-90
        • Dunford R
        • Salinaro A
        • Cai L
        • et al.
        Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients.
        FEBS Lett. 1997; 418: 87-90
        • Serpone N
        • Lawless D
        • Khairutdinov R
        Subnanosecond relaxation dynamics in TiO2 colloidal sols (particle sizes Rp = 1.0–13.4 nm). Relevance to heterogenous photocatalysis.
        J Phys Chem. 1995; 99: 16655-16661
        • Lawless D
        • Serpone N
        • Meisel D
        Role of OH radicals and trapped holes in photocatalysis. A pulse radiolysis study.
        J Phys Chem. 1991; 95: 5166-5170
        • Jaeger C
        • Bard A
        Spin trapping and electron spin resonance detection of radical intermediates in photodecomposition of water at TiO2 particulate systems.
        J Phys Chem. 1979; 83: 3146-3152
        • Saito T
        • Iwase T
        • Horie J
        • Morioka T
        Mode of pohtocatalytic bactericidal action of powdered semiconductor TiO2 on mutants streptococci.
        J Photochem Photobiol. 1992; 14: 369-379
        • Sakai H
        • Ito E
        • Cai R
        • Yoshioka T
        Intracellular Ca+2 concentration change of T24 cell under irradiation in the presence of TiO2 ultrafine particles.
        Biochem Biophys Acta. 1994; 1201: 259-265
        • Wamer W
        • Yin J
        • Wei R
        Oxidative damage to nucleic acids photosensitized by titanium dioxide.
        Free Rad Biol Med. 1997; 23: 851-858
        • Sunada K
        • Kukuchi Y
        • Hashimoto K
        • Fujishima A
        Bactericidal and detoxification effects of TiO2 thin film photocatalysts.
        Environ Sci Technol. 1998; 32: 726-728
        • Maness P
        • Smokinski S
        • Blake D
        • et al.
        Bactericidal activity of photocatalytic TiO2 reaction.
        App Environ Microbiol. 1999; 65: 4094-4098
        • Lademann J
        • Weigmann H
        • Schafer H
        • et al.
        Investigation of the stability of coated titanium microparticles used in sunscreens.
        Skin Pharmacol Appl Skin Physiol. 2000; 13: 258-264
        • Dussert A
        • Gooris E
        • Hemmerle J
        Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum.
        Int J Cosmet Sci. 1997; 19: 119-129
        • Idaka H
        • Horikoshia S
        • Serpone N
        • Knowland J
        In vitro photochemical damage to DNA, RNA and their bases by an inorganic sunscreen agent on exposure to UVA and UVB radiation.
        Photochem Photobiol. 1997; 111: 205-213
        • Greiter F
        Sonnenschutzfaktor-entstehung. Methodik.
        Perfumerie und Kosmetik. 1984; 55: 70
      2. U.S. Food and Drug Administration. Sunscreen drug products for over-the-counter human drugs; proposed safety, effectiveness, and labeling conditions. In: Anonymous Federal Register. Washington, D.C.: Department of Health, Education and Welfare, Food and Drug Administration., 1978:38206–69.

        • Diffey B
        Has the sun protection factor had its day?.
        Br Med J. 2000; 320: 176-177
        • Autier P
        • Severi G
        • Dore J
        • Boniol M
        Has the sun protection factor had its day?.
        Br Med J. 2000; 320 ([Letter]): 1274-1275
        • Stenberg C
        • Larko O
        Sunscreen application and its importance for the sun protection factor.
        Arch Dermatol. 1985; 121: 1400-1402
        • Bech-Thomsen N
        • Wulf H
        Sunbathers’ application of sunscreen is probably inadequate to obtain the sun protection factor assigned to the preparation.
        Photodermatol Photoimmunol Photomed. 1993; 9: 242-244
        • Stokes R
        • Diffey B
        How well are sunscreen users protected?.
        Photodermatol Photoimmunol Photomed. 1997; 13: 186-188
        • Wulf H
        • Stender I
        • Lock-Andersen J
        Sunscreens used at the beach do not protect against erythema.
        Photodermatol Photoimmunol Photomed. 1997; 13: 129-132
        • Autier P
        • Dore J
        • Negrier S
        • et al.
        Sunscreen use and duration of sun exposure.
        J Natl Cancer Inst. 1999; 91: 1304-1309
      3. U.S. Food and Drug Administration. Sunscreen drug products for over-the-counter human use: Final monograph. In: Federal Register. Washington D.C.: Department of Health, Education and Welfare, Food and Drug Administration, 1999:27666–93.

        • Deflandre A
        • Lang G
        Photostability assessment of sunscreens.
        Int J Cosmet Sci. 1988; 10: 53-62
        • Tarras-Wahlberg N
        • Stenhagen G
        • Larko O
        • et al.
        Changes in ultraviolet absorption of sunscreens after ultraviolet irradiation.
        J Invest Dermatol. 1999; 113: 547-553
        • Naylor M
        • Kevin C
        The case of sunscreens. A review of their use in preventing actinic damage and neoplasia.
        Arch Dermatol. 1997; 133: 1146-1154
        • Kopf A
        • Krupke M
        • Stern T
        Sun and malignant melanoma.
        J Am Acad Dermatol. 1984; 11: 674-684
        • Armstrong B
        • Kricker A
        How much melanoma is caused by sun exposure?.
        Melanoma Res. 1993; 3: 395-401
        • Tsao H
        • Sober A
        Ultraviolet radiation and malignant melanoma.
        Clin Dermatol. 1998; 16: 67-73
        • Wolf R
        • Oumeish Y
        Photodermatoses.
        Clin Dermatol. 1998; 16: 41-57
        • Whiteman D
        • Green A
        Melanoma and sun exposure.
        Int J Dermatol. 1999; 38: 481-489
        • Elwood J
        • Jopson J
        Melanoma and sun exposure.
        Int J Cancer. 1997; 73: 198-203
        • Gilchrest B
        • Eller M
        • Geller A
        • Yaar M
        The pathogenesis of melanoma induced by ultraviolet radiation.
        N Engl J Med. 1999; 340: 1341-1348
        • Weinstock M
        Do sunscreens increase or decrease melanoma risk.
        J Invest Dermatol Symp Proc. 1999; 4: 97-100
        • Bigby M
        The sunscreen and melanoma controversy.
        Arch Dermatol. 1999; 135: 1526-1527
        • Klepp O
        • Magnus K
        Some environmental and bodily characteristics of melanoma patients. A case-control study.
        Int J Cancer. 1979; 23: 482-486
        • Graham S
        • Marshall J
        • Haughey B
        • et al.
        An inquiry into the epidemiology of melanoma.
        Am J Epidemiol. 1985; 122: 606-619
        • Beitner H
        • Norell S
        • Ringborg U
        • Wennersten G
        • Mattson B
        Malignant melanoma.
        Br J Dermatol. 1990; 122: 43-51
        • Herzfeld P
        • Fitzgerald E
        • Hwang S
        • Stark A
        A case-control study of malignant melanoma of the trunk among white males in upstate New York.
        Cancer Detect Prev. 1993; 17: 601-608
        • Westerdahl J
        • Olsson H
        • Masback A
        • Ingvar C
        • Jonsson N
        Is the use of sunscreens a risk factor for malignant melanoma?.
        Melanoma Res. 1995; 5: 59-65
        • Autier P
        • Dore J
        • Schifflers E
        • et al.
        Melanoma and use of sunscreens.
        Int J Cancer. 1995; 61: 749-755
        • Wolf P
        • Quehenberger F
        • Mullegger R
        • et al.
        Phenotypic markers, sunlight-related factors and sunscreen use in patients with cutaneous melanoma.
        Melanoma Res. 1998; 8: 370-378
        • Whiteman D
        • Valery P
        • McWhirter W
        • Green A
        Risk factors for childhood melanoma in Queensland, Australia.
        Int J Cancer. 1997; 70: 26-31
        • Westerdahl J
        • Ingvar C
        • Masback A
        • Olsson H
        Sunscreen use and malignant melanoma.
        Int J Cancer. 2000; 87: 145-150
        • Holman C
        • Armstrong B
        • Heeman P
        Relationship of cutaneous malignant melanoma to individual sunlight-exposure habits.
        J Natl Cancer Inst. 1986; 76: 403-414
        • Osterlind A
        • Tucker M
        • Stone B
        • Jensen O
        The Danish case-control study of cutaneous malignant melanoma. II. Importance of UV-light exposure.
        Int J Cancer. 1988; 42: 319-324
        • Naldi L
        • Gallus S
        • Imberti L
        • et al.
        Sunscreens and cutaneous malignant melanoma.
        Int J Cancer. 2000; 86: 879-882
        • Green A
        • Bain C
        • McLennan R
        • Siskind V
        Risk factors for cutaneous melanoma in Queensland.
        Recent Results Cancer Res. 1986; 102: 76-97
        • Holly E
        • Aston D
        • Cress R
        • Ahn D
        • Kristiansen J
        Cutaneous melanoma in women, I. Exposure to sunlight, ability to tan, and other risk factors related to ultraviolet light.
        Am J Epidemiol. 1995; 141: 923-933
        • Rodenas J
        • Delgado-Rodriguez M
        • Herranz M
        • Tercedor J
        • Serrano S
        Sun exposure, pigmentary traits, and risk of cutaneous malignant melanoma.
        Cancer Causes Control. 1996; 7: 275-283
        • Autier P
        Sunscreen and melanoma revisited.
        Arch Dermatol. 2000; 136 ([Letter]): 423
        • Rosen C
        Photoprotection.
        Sem Cut Med Surg. 1999; 18: 307-314
        • Naylor M
        The case for sunscreens revisited. Reply.
        Arch Dermatol. 1998; 134 ([letter]): 510
        • Swerdlow A
        • English J
        • MacKie R
        • et al.
        Benign melanocytic naevi as a risk factor for malignant melanoma.
        Br Med J (Clin Res Ed). 1986; 292: 1555-1559
        • Holly E
        • Kelly J
        • Shpall S
        • Chiu S
        Number of melanocytic nevi as a major risk factor for malignant melanoma.
        J Am Acad Dermatol. 1984; 17: 459-468
        • Autier P
        • Dore J
        • Cattaruzza M
        • et al.
        Sunscreen use, wearing clothes, and number of nevi in 6- to 7-year-old European children. European Organization for Research and Treatment of Cancer Melanoma.
        J Natl Cancer Inst. 1998; 90: 1873-1880
        • Gallagher R
        • Rivers J
        • Lee T
        • et al.
        Broad-spectrum sunscreen use and the development of new nevi in white children. A randomized controlled trial.
        JAMA. 2000; 283: 2955-2960
        • Richens J
        • Imrie J
        • Copas A
        Condoms and seat belts.
        Lancet. 2000; 355: 400-403
        • Stender I
        • Andersen J
        • Wulf H
        Sun exposure and sunscreen use among sunbathers in Denmark.
        Acta Derm Venereol (Stockh). 1996; 76: 31-33
        • Weinstock M
        • Rossi J
        The Rhode Island Sun Smart Project.
        Clin Dermatol. 1998; 16: 411-413
        • Kircker A
        • Armstrong B
        • English D
        • Heeman P
        Does intermittent sun exposure cause basal cell carcinoma? A case-control study in Western Australia.
        Int J Cancer. 1995; 60: 489-494
        • Hunter D
        • Colditz G
        • Stampfer M
        • et al.
        Risk factors for basal cell carcinoma in a prospective cohort of women.
        Ann Epidemiol. 1990; 1: 13-23
        • Harvey I
        • Frankel S
        • Marks R
        • et al.
        Non-melanoma skin cancer and solar keratoses. II. Analytical results of the South Wales Skin Cancer Study.
        Br J Cancer. 1996; 74: 1308-1312
        • Harth Y
        • Ulman Y
        • Peled I
        • Friedman-Birnbaum R
        Sun protection and sunscreen use after surgical treatment of basal cell carcinoma.
        Photodermatol Photoimmunol Photomed. 1995; 11: 140-142
        • Kircker A
        • Armstrong B
        • English D
        • Heenan P
        A dose-response curve for sun exposure and basal cell carcinoma.
        Int J Cancer. 1995; 60: 482-488
        • Zanetti R
        • Rosso S
        • Martinez C
        • et al.
        The multicenter south European Study ‘Helios’. I. Skin characteristics and sunburns in basal cell and squamous cell carcinomas of the skin.
        Br J Cancer. 1996; 73: 1440-1446
        • Kraemer K
        • Lee M
        • Andrews A
        • Lambert W
        The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer.
        Arch Dermatol. 1994; 130: 1018-1021
        • Mintz B
        • Silvers W
        Transgenic mouse model of malignant skin melanoma.
        Proc Natl Acad Sci USA. 1993; 90: 8817-8821
        • Kelsall S
        • Mintz B
        Metastatic cutaneous melanoma promoted by ultraviolet radiation in mice with transgene-initiated low melanoma susceptibility.
        Cancer Res. 1998; 58: 4061-4065
        • Atillasoy E
        • Seykora J
        • Soballe P
        • et al.
        UVB induces atypical melanocytic lesions and melanoma in human skin.
        Am J Pathol. 1998; 152: 1179-1186
        • Setlow R
        • Grist E
        • Thompson K
        • Woodhead A
        Wavelength effective in induction of malignant melanoma.
        Proc Natl Acad Sci USA. 1993; 90: 6666-6670
        • Setlow R
        Spectral regions contributing to melanoma.
        J Invest Dermatol Symp Proc. 1999; 4: 46-49
      4. Woodhead A, Setlow R, Tanaka M. Environmental factors in nonmelanoma and melanoma skin cancer. J Epidemiol 1999;9(6 Suppl):S102–S114

        • Gasparro F
        Sunscreens, skin photobiology, and skin cancer.
        Environ Health Perspect. 2000; 108: 71-78