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Abstract
Our current knowledge of androgenetic alopecia and hair follicle metabolism and control
has evolved from four phases of scientific evolution. In the first phase, which I
have called the era of science, investigators made strides in understanding androgen
metabolism in general and clarified the role of androgens in androgenetic alopecia
in particular. This phase was followed by what I have labeled the era of antiandrogens
when they were sought as the ideal and only treatment for androgenetic alopecia. Though
valid, this approach has proved to be limited. The third phase of scientific progress,
the era of biologic response modifiers, evolved when investigators discovered a group
of unrelated drugs that promoted hair growth. These drugs have a variety of physiologic
effects and may act synergistically to stimulate hair follicle growth. Finally, we
are on the threshold of the fourth phase, the era of predictability, in which research
efforts will focus on finding the active hair growth-promoting sites on these drug
molecules, and on clarifying how these drugs, such as minoxidil, stimulate hair growth
on physiologic, pharmacologic, biochemical, and molecular levels.
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References
- Male hormone stimulation is prerequisite and an incitant in common baldness.Am J Anat. 1942; 71: 451-480
- Autografts in alopecias and other selected dermatological conditions.Ann NY Acad Sci. 1959; 83: 463-479
- Metabolism of testosterone by the human prostate.JAMA. 1963; 183: 436-439
- The conversion of testosterone to 5α-androstan-17β-ol-3-one by rat prostate in vivo and in vitro.J Biol Chem. 1968; 243: 2012-2021
- Recent studies on the mechanism of action of testosterone.N Engl J Med. 1972; 287: 1284-1291
- Mechanisms of androgen-mediated hair growth.in: Proceedings of the First International Congress on Hair Research, Hamburg, March 13–16, 19796th ed. Hair Research. Status and Future Aspects. Springer-Verlag, New York1981: 205-209
- The mechanism of action of androgens.Monogr Endocrinol. 1977; 10: 1-178
- Studies on the pathogenesis of the pseudohermaphroditism in the mouse with testicular feminization.J Clin Invest. 1972; 51: 1647-1658
- Steroid 5α-reductase deficiency in man: an inherited form of male pseudohermaphroditism.Science. 1974; 186: 1213-1215
- Androgenetic alopecia.in: Thiers BH Dobeon RL Pathogenesis of Skin Disease. Churchill Livingstone, New York1986: 41-55
- Regulation of human hair growth by steroid hormones. I. Testosterone metabolism in isolated hairs.J Clin Endocrinol Metab. 1974; 38: 811-819
- Studies of common baldness of the stump-tailed macaque (Macaco, speciosa): VI. The effect of testosterone on common baldness.Arch dermatol. 1971; 103: 527-534
- Testosterone metabolism in the skin: a review of its function in androgenetic alopecia, acne vulgaris, and idiopathic hirsutism including recent studies with antiandrogens.Arch dermatol. 1975; 111: 1496-1502
- Regulation of human hair growth by steroid hormones. II. Androetenedione metabolism in isolated hairs.J Clin Endocrinol Metab. 1974; 39: 1012-1019
- Stumptailed macaques as a model of male-pattern baldness.in: 6th ed. Models in Dermatology. 3. Karger, Basel1987: 159-169
- Studies of common baldness in the Stumptailed macaque: IV. In vitro metabolism of testosterone in the hair follicles.J Invest dermatol. 1970; 55: 329-334
- The metabolism and control mechanism of human hair follicles.Curr Probl dermatol. 1973; 5: 37-78
- Adenyl cyclase in human hair follicles. Its inhibition by dihydrotestosterone.Biochem Biophys Res Commun. 1970; 41: 884-890
- The inheritance of common baldness: two B or not to B?.J Am Acad dermatol. 1984; 11: 921-926
- Patterned loss of hair in man: types and incidence.Ann NY Acad Sci. 1951; 53: 708-728
- Diseases of the Hair and Scalp.in: Blackwell Scientific Publications, Oxford1982: 95-99
- Male pattern alopecia and masculinity.Br J dermatol. 1979; 100: 567-571
- Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex.Br J dermatol. 1977; 97: 247-254
- Use of cyproterone acetate (CPA) in the treatment of acne, hirsutism and virilism.J Steroid Biochem. 1975; 6: 827
- Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject.Br J dermatol. 1977; 97: 371-381
- Oral anti-androgen treatment of common baldness in women.Br J dermatol. 1982; 107: 20
- Antiandrogens—scientific and experimental background.in: Proceedings of the First International Congress on Hair Research, Hamburg, March 13–16, 19796th ed. Hair Research. Status and Future Aspects. Springer-Verlag, New York1981: 322-329
- Transformation of testosterone into 17β-hydroxy-5α-androstan-3-one by microsomal preparations of human skin.J Biol Chem. 1970; 245: 5594-5599
- Antiandrogens.in: James VHT Martini L Proceedings of the Third International Congress on Hormonal Steroids, Hamburg, 1970 Excerpta Medica, Amsterdam1971: 995-1006
- Treatment of hirsutism with spironolactone.JAMA. 1982; 247: 1295-1298
- Treatment of hirsute women with cimetidine. A preliminary report.N Engl J Med. 1980; 303: 1042
- The pharmacologie basis of antihypertensive therapy: the role of vasodilator drugs.Prog Cardiovasc Dis. 1974; 17: 99-113
- Hypertrichosis due to diazoxide.Br J dermatol. 1975; 93: 707-711
- Metabolism of viprostol—a synthetic vasodilator PGE2 analog.Prostaglandins. 1986; 31: 811-827
- Hypertrichosis and multiple cutaneous squamous cell carcinomas in association with cyclosporin A therapy.J R Soc Med. 1983; 76: 786-787
- Topical tretinoin for hair growth promotion.J Am Acad dermatol. 1986; 15: 880-883
- The direct effects of biological response modifiers on epidermal cells.Br J dermatol. 1984; 111: 114-122
- Action of topical minoxidil in the bald stump-tailed macaque.J Am Acad dermatol. 1987; 16: 657-658
- Pharmacology of diazoxide, an antihypertensive, nondiuretic benzothiadiazine.J Pharmacol Exp Ther. 1962; 136: 344-352
- The effects of diazoxide and benzothiadiazine diuretics upon phosphodiesterase.Ann NY Acad Sci. 1968; 150: 256-260
- Cyclosporin A.J Am Acad dermatol. 1986; 14: 785-791
- Dermatologie applications of cyclosporine.Arch dermatol. 1986; 122: 1028-1032
- Mechanism of action of retinoids.J Am Acad dermatol. 1986; 15: 756-764
- Retinoic acid: Biochemistry and metabolism.J Am Acad dermatol. 1986; 15: 741-747
- Retinoid effects on epidermal differentiation.in: Saurat JH Retinoids: New Trends in Research and Therapy. S Karger, Basel, Switzerland1985: 138-158
- Topical retinoic acid enhances the regrowth of ultraviolet damaged dermal connective tissue.Connect Tissue Res. 1984; 12: 139-150
- Vitamin A and wound healing.J Am Acad dermatol. 1986; 15: 817-821
- Epidermal effects of retinoids: supramolecu lar observations and clinical implications.J Am Acad dermatol. 1986; 15: 797-809
- Structure and tissue distribution of some retinoid-binding proteins.J Invest dermatol. 1983; 81: 59s-63s
- Direct effects of phenytoin on epithelial cells in vitro.J Dental Research. 1984; 63: 261
- Drugs effective in the therapy of the epilepsies.in: Gilman AG Goodman LS Gilman A The Pharmacological Basis of Therapeutics. 6th ed. Macmillan, New York1980: 448-474
- Hypertrichosis occurring in association with Dilantin therapy.J Pediatr. 1955; 47: 351-352
- Direct effects of minoxidil on epidermal cells in culture.J Invest dermatol. 1984; 82: 90-93
- Effect of minoxidil on cultured keratinocytes.J Invest dermatol. 1983; 81: 558-560
- Local interactions in mammalian hair growth.in: The Skin of Vertebrates. Linnean Society Symposium Series. 9. Academic, London1980: 199-210
- Topical tretinoin for photoaged skin.J Am Acad dermatol. 1986; 15: 836-869
- Lipid angiogenic factor from omentum.JAMA. 1984; 252: 2034-2036
- Alopecia areata treated with topical minoxidil.Arch dermatol. 1984; 120: 457-463
- Potential mechanisms of minoxidil induced hair growth in alopecia areata.J Am Acad dermatol. 1987; 16: 653-656
- Topical minoxidil (3%) in extensive alopecia areata, including long-term efficacy.J Am Acad dermatol. 1987; 16: 737-744
- Topical minoxidil therapy in hereditary androgenetic alopecia.Arch dermatol. 1985; 121: 197-202
- Topical minoxidil in early male pattern baldness.J Am Acad dermatol. 1985; 13: 185-192
- Minoxidil sulfate produces vasodilation by increasing plasmalemmel K+ permeability.in: Presented at the Brook Lodge Symposium, Androgenetic Alopecia, Kalamazoo, Michigan, February 16–181987
- Clinical and histologie studies of male pattern baldness treated with topical minoxidil.Curr Ther Res. 1984; 36: 1098-1106
- Transverse microscopic anatomy of the human scalp: a basis for a morphometric approach to disorders of the hair follicle.Arch dermatol. 1984; 120: 449-456
- Image analysis of hair follicles in biopsy specimens.in: Presented at the Brook Lodge Symposium, Androgenetic Alopecia, Kalamazoo, Michigan, February 16–181987
- Two forms of androgen receptor protein in human hair follicles and sebaceous glands: variation in transitional and bald scalp.J Invest dermatol. 1988; 90: 606
- Translocation of androgen-receptor protein complex into nuclei of hair follicles and sebaceous glands from human scalp.J Invest dermatol. 1988; 90: 605
- Presence of an inhibitor to androgen binding to receptor protein in human sebaceous gland and hair follicle.J Invest dermatol. 1988; 90: 605
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© 1988 Published by Elsevier Inc.
