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Abstract
Minoxidil (2–4 diamino-6-piperidine-pyrimidine-5-oxide) is a directacting peripheral
arteriolar vasodilator that reduces peripheral vascular resistance. It was first marketed
by The Upjohn Company in 1979 as Loniten® Tablets for the treatment of severe hypertension.
The peripheral vasodilation caused predictable cardiovascular effects, such as lowered
blood pressure, reflex tachycardia, and fluid retention.1 Canine cardiac lesions were reported in toxicology studies, but no such findings
are evident in humans.2
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References
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© 1988 Published by Elsevier Inc.
