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Abstract
The histopathology of androgenetic alopecia is characterized by reductions in follicular
size and mean hair shaft diameter without significant reduction in follicular density.1 The proportion of hairs found in anagen is diminished with a corresponding increase
in hairs in normal telogen, plus a marked increase in a persistent stage of telogen.
The telogen germinal unit is the term given by Headington2 to the structure that represents a persistence of telogen after shedding of the club
hair but in which anagen has not been re-established.
Regrowth of scalp hair following topical application of minoxidil has been demonstrated
in both primates3,4 and humans5,6 suffering from androgenetically determined alopecia. As part of a nationwide multicenter
trial of topical minoxidil in male-pattern alopecia, scalp biopsy specimens were obtained
before and after treatment to determine what histopathologic changes might be found
and if this might help us understand the way in which the clinically observed regrowth
of hair might occur.
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References
- Pathology of male pattern alopecia.Arch dermatol. 1984; 120: 1607-1608
- Transverse microscopic anatomy of the human scalp, a basis for a morphometric approach to disorders of the hair follicle.Arch dermatol. 1984; 120: 449-456
- Cappas A.Clin Res. 1984; 32: 621A
- Transformation of hair follicles and the therapeutic effect of minoxidil on the bald scalp of stumptailed macaques.Chron dermatol. 1985; 16: 565-583
- Topical minoxidil therapy in hereditary androgenetic alopecia.Arch dermatol. 1985; 121: 197-202
- Clinical and histologic studies of male pattern baldness treated with topical minoxidil.Curr Ther Res. 1984; 36: 1098-1106
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© 1988 Published by Elsevier Inc.
