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The use of the stumptailed macaque, which possesses hereditary balding characteristics similar in many respects to that of androgenetic alopecia in humans, enables us to obtain a morphometric assessment of the rate of cyclic change of the hair follicle. The analysis of folliculograms results in data that can determine the rate of cyclic progression (resting to regrowing phase, and regrowing to late anagen phase) and the overall change in follicular size. Topical minoxidil apparently activates the resting follicles in the bald scalp and stimulates their cyclic progression. It also increases DNA synthesis, resulting in relative enlargement of the growing anagen follicles. All minoxidil-treated animals had hair regrowth, although in varying degrees of restoration to the prebald condition and after varying durations of treatment. In general, the response was greater in the younger, early-bald stumptailed macaques compared with the older, advancedbald animals. The degree of response varied from regrowth of thicker, darker hairs over the entire bald area, with folliculograms showing corresponding large proportions of late anagen follicles, to the arresting of the balding process, with folliculograms showing maintenance of moderate populations of anagen follicles. Cessation of topical minoxidil treatment resulted in a renewal of the balding process, with folliculograms demonstrating increases in the proportion of resting follicles. This withdrawal from treatment apparently had no effect on hair regrowth during subsequent reapplications of minoxidil. Such treatment resulted in regrowth similar to that in the first treatment phase. Continuous treatment of topical minoxidil for 4 years has not resulted in systemic or local side effects in these animals.
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☆Supported by Grant RR00167 to the Wisconsin Regional Primate Research Center from the National Institutes of Health and a grant from The Upjohn Company, Kalamazoo, Michigan.
☆☆This is publication #28-012 of the Wisconsin Regional Primate Research Center.
© 1988 Published by Elsevier Inc.