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Abstract
The work of Montagna, Uno, and others1–4 using the stumptailed macaque as a nonhuman baldness model has contributed to further
advancement of our understanding of hair loss by providing a model to test various
therapeutic modalities; however, the small number of macaques available and the high
cost of maintaining these animals unfortunately limit their use in hair research.
Although mutations for hair loss occur frequently in laboratory rodents, to the best
of our knowledge, androgen-mediated alopecia has never been described. This report
demonstrates a mutation in our mouse colony in which the onset of alopecia is dependent
upon the presence of androgens. Because alopecia in this mutation parallels that of
baldness in man, we propose the use of this animal as an alternative model for studying
the mechanism or mechanisms controlling the balding phenomenon and for screening of
compounds that may be of therapeutic value.
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References
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- The effects of androgens, antiandrogens, and vasodilating agents on hair loss in the androchronogenetic alopecia mouse model.in: 6th ed. Dermatology in 5 Continents: Proceedings of the 17th World Congress of Dermatology. 92. Springer-Verlag, Berlin1987
Matias J, Orentreich N. Animal models of androgen dependent disorders of the pilo-sebaceous apparatus. I. The androchronogenetic alopecia mouse as a model for male pattern baldness. Arch Dermatol Res. (submitted for publication).
Matias J, Orentreich N. Animal models of androgen dependent disorders of the pilo-sebaceous apparatus. II. The long-haired hamster as a model for hirsutism. Arch Dermatol Res. (submitted for publication).
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© 1988 Published by Elsevier Inc.
