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Abstract
The hairless mouse may seem an unlikely model for assessing the influence of drugs
on hair growth. Although the animal's first pelage is normal, a defect in the first
catagen results in separation of the papilla from the shortening follicle.1,2 These never reconnect, and the animal remains hairless thereafter. The scanty second
pelage that occasionally occurs in some animals derives from a few surviving follicles.
This research was undertaken to determine whether minoxidil might interfere with the
follicular catastrophe at the end of the first pelage. The evidence of a second pelage
would provide a quick and convenient end point. This article describes a preliminary
study with minoxidil applied topically to Skh-hairless-1 neonate and weanling mice.
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References
- The skin of hairless mice. I. The formation of cysts and the distribution of lipids.J Invest dermatol. 1952; 19: 83-94
- Hair loss and cyst formation in hairless and rhino mutant mice.Anat Rec. 1971; 170: 485-499
- Cyclosporin A stimulates hair growth in nude mice.Lab Invest. 1987; 56: 684-686
- Biology of hair growth.in: 6th ed. Seminars in Reproductive Endocrinology. 4. 1986: 131-141
- The influence of testosterone, cyproterone acetate, amd minoxidil on hair loss in the androchonogenetic alopecia mouse.Clin dermatol. 1988; : 169-176
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© 1988 Published by Elsevier Inc.
