Research Article| Volume 6, ISSUE 4, P163-168, October 1988

The hairless mouse as a model for evaluating promoters of hair growth

  • Lorraine H. Kligman
    Address for correspondence: Lorraine H. Kligman, PhD, Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.
    From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania USA
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      The hairless mouse may seem an unlikely model for assessing the influence of drugs on hair growth. Although the animal's first pelage is normal, a defect in the first catagen results in separation of the papilla from the shortening follicle.1,2 These never reconnect, and the animal remains hairless thereafter. The scanty second pelage that occasionally occurs in some animals derives from a few surviving follicles. This research was undertaken to determine whether minoxidil might interfere with the follicular catastrophe at the end of the first pelage. The evidence of a second pelage would provide a quick and convenient end point. This article describes a preliminary study with minoxidil applied topically to Skh-hairless-1 neonate and weanling mice.
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