Research Article| Volume 6, ISSUE 4, P159-162, October 1988

Animal models of alopecia

  • J.Michael Holland
    Address for correspondence: J Michael Holland, DVM, PhD, The Upjohn Company, Pathology and Toxicology Research, 301 Henrietta Street, Kalamazoo, MI 49007.
    From the Section on Pathology and Toxicology Research, The Upjohn Company, Kalamazoo, Michigan USA
    Search for articles by this author
      This paper is only available as a PDF. To read, Please Download here.


      A genetic model of androchronogenic alopecia has yet to be described in the rat or mouse, two of the better characterized species. It may be relevant that the best current animal model of androchronogenic alopecia, the stumptailed macaque, 21–23 is a primate. The age of onset and the pattern of hair loss closely resemble human male-pattern baldness and morphologically, as well as mechanistically, may be analogous to the corresponding process in humans. Since genetically controlled regional hairlessness is a phenomenon relatively unique to Homo sapiens, it may be too much to expect to find an analogous process among rodents.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Clinics in Dermatology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


      1. Green MC Genetic Variants and Strains of the Laboratory Mouse. Fischer, Stuttgart1981: 1-476
        • Dickie MM
        Alopecia, a dominant mutation in the house mouse.
        J Hered. 1955; 46: 31-34
        • Tutikawa K
        Studies on an apparently new mutant, “alopecia periodica” found in the mouse.
        Ann Rep Nat Inst Genet Jap. 1952; 3: 9-10
        • Falconer DS
        • Fraser AS
        • King JWB
        The genetics and development of “crinkled,” a new mutant in the house mouse.
        J Genet. 1951; 50: 324-344
        • Falconer DS
        • Snell GD
        Two new hair mutants, rough and frizzy, in the house mouse.
        J Hered. 1952; 43: 53-57
        • Green EL
        The genetics of a new hair deficiency, furless, in the house mouse.
        J Hered. 1954; 45: 115-118
        • Mann SJ
        The hair of fuzzy mice.
        J Hered. 1964; 55: 121-123
        • David LT
        The external expression and comparative dermal histology of hereditary hairlessness in mammals.
        Z Zellforsch Mikro Anat. 1932; 14: 616-719
        • Fraser FC
        The expression and interaction of hereditary factors producing nypotrichosis in the mouse: histology and experimental results.
        Can J Res. 1946; 24: 10-25
        • Montagna WC
        • Chase HB
        • Melaragno HP
        The skin of hairless mice. I. The formation of cysts and the distribution of lipids.
        J Invest dermatol. 1952; 19: 83-94
        • Mann SJ
        Hair loss and cyst formation in hairless and rhino mutant mice.
        Anat Rec. 1971; 170: 485-500
        • Raphael KA
        • Chapman RE
        • Frith PA
        • et al.
        The structure of hair and follicles of mice carrying the naked (N) gene.
        Genet Res. 1982; 39: 139-148
        • Flanagen SP
        Nude, a new hairless gene with pleiotropic effects in the mouse.
        Genet Res. 1966; 8: 295-309
        • Slee J
        Developmental morphology of the skin and hair follicles in normal and in ‘ragged’ mice.
        J Embryol Exp Morphol. 1962; 10: 507-529
        • Kligman LH
        The hairless mouse as a model for evaluating promoters of hair growth.
        Clin dermatol. 1988;
        • Palm J
        • Ferguson FG
        Fuzzy, a hypotrichotic mutant in linkage group I of the norway rat.
        J Hered. 1976; 67: 284-288
        • Ferguson FG
        • Irving GW
        • Stedham M
        Three variations of hairlessness associated with albinism in the laboratory rat.
        Lab Anim Sci. 1979; 29: 459-465
        • Greaves JH
        • Ayres PB
        Fuzzy: a genetic marker for warfarin resistance in the norway rat.
        Lab Anim. 1985; 19: 145-147
        • Inazu M
        • Sakaguchi T
        Morphologic characteristics of the skin of bald mutant rats.
        Lab Anim Sci. 1984; 34: 584-587
        • Festing MFW
        • May D
        • Connors TA
        • et al.
        An athymic nude mutation in the rat.
        Nature. 1978; 274: 365-366
        • Uno H
        Nonhuman primate model of baldness, Premature aging of hair follicle and hormones.
        Int J dermatol. 1982; 21: 21-23
        • Uno H
        • Montagna W
        Reinnervation of hair follicle end organs and meissner corpuscles in skin grafts of Macaques.
        J Invest dermatol. 1982; 78: 210-214
        • Uno H
        • Cappas A
        • Schlagel C
        Cyclic dynamics of hair follicles and the effect of minoxidil on the bald scalps of stumptailed macaques.
        Am J Dermatopathol. 1985; 7: 283-297