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A genetic model of androchronogenic alopecia has yet to be described in the rat or mouse, two of the better characterized species. It may be relevant that the best current animal model of androchronogenic alopecia, the stumptailed macaque, 21–23 is a primate. The age of onset and the pattern of hair loss closely resemble human male-pattern baldness and morphologically, as well as mechanistically, may be analogous to the corresponding process in humans. Since genetically controlled regional hairlessness is a phenomenon relatively unique to Homo sapiens, it may be too much to expect to find an analogous process among rodents.
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- Green MC Genetic Variants and Strains of the Laboratory Mouse. Fischer, Stuttgart1981: 1-476
- Alopecia, a dominant mutation in the house mouse.J Hered. 1955; 46: 31-34
- Studies on an apparently new mutant, “alopecia periodica” found in the mouse.Ann Rep Nat Inst Genet Jap. 1952; 3: 9-10
- The genetics and development of “crinkled,” a new mutant in the house mouse.J Genet. 1951; 50: 324-344
- Two new hair mutants, rough and frizzy, in the house mouse.J Hered. 1952; 43: 53-57
- The genetics of a new hair deficiency, furless, in the house mouse.J Hered. 1954; 45: 115-118
- The hair of fuzzy mice.J Hered. 1964; 55: 121-123
- The external expression and comparative dermal histology of hereditary hairlessness in mammals.Z Zellforsch Mikro Anat. 1932; 14: 616-719
- The expression and interaction of hereditary factors producing nypotrichosis in the mouse: histology and experimental results.Can J Res. 1946; 24: 10-25
- The skin of hairless mice. I. The formation of cysts and the distribution of lipids.J Invest dermatol. 1952; 19: 83-94
- Hair loss and cyst formation in hairless and rhino mutant mice.Anat Rec. 1971; 170: 485-500
- The structure of hair and follicles of mice carrying the naked (N) gene.Genet Res. 1982; 39: 139-148
- Nude, a new hairless gene with pleiotropic effects in the mouse.Genet Res. 1966; 8: 295-309
- Developmental morphology of the skin and hair follicles in normal and in ‘ragged’ mice.J Embryol Exp Morphol. 1962; 10: 507-529
- The hairless mouse as a model for evaluating promoters of hair growth.Clin dermatol. 1988;
- Fuzzy, a hypotrichotic mutant in linkage group I of the norway rat.J Hered. 1976; 67: 284-288
- Three variations of hairlessness associated with albinism in the laboratory rat.Lab Anim Sci. 1979; 29: 459-465
- Fuzzy: a genetic marker for warfarin resistance in the norway rat.Lab Anim. 1985; 19: 145-147
- Morphologic characteristics of the skin of bald mutant rats.Lab Anim Sci. 1984; 34: 584-587
- An athymic nude mutation in the rat.Nature. 1978; 274: 365-366
- Nonhuman primate model of baldness, Premature aging of hair follicle and hormones.Int J dermatol. 1982; 21: 21-23
- Reinnervation of hair follicle end organs and meissner corpuscles in skin grafts of Macaques.J Invest dermatol. 1982; 78: 210-214
- Cyclic dynamics of hair follicles and the effect of minoxidil on the bald scalps of stumptailed macaques.Am J Dermatopathol. 1985; 7: 283-297
© 1988 Published by Elsevier Inc.