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Abstract
Minoxidil has been shown to induce hair regrowth in alopecia areata1–4 by mechanisms that remain largely unknown. Alopecia areata is histologically characterized
by miniaturized follicles with varying degrees of degeneration5 and by a dense perifollicular infiltration of T lymphocytes (helper, suppressor,
and activated), Langerhans cells, and monocytes.6,7 T lymphocytes appear to be the predominant cell type in the perifollicular infiltrates
and, by implication, may be of pathogenic significance in the hair loss process. Changes
in perifollicular T-cell and activated T-cell populations have been found after treatment
with minoxidil.7 Responders to topical 5% minoxidil treatment (ie, those patients who had terminal
hair regrowth) have shown decreases in tissue T cells and simultaneous increases in
peripheral blood T cells.7
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References
- Alopecia areata treated with topical minoxidil.Arch dermatol. 1984; 120: 457-463
- Topical minoxidil dose-response effect in alopecia areata.Arch dermatol. 1986; 122: 180-182
- Topical minoxidil solution (1% and 5%) in the treatment of alopecia areata.J Am Acad dermatol. 1987; 16: 745-748
- Evaluation of oral minoxidil in the treatment of alopecia areata.Arch dermatol. 1987; 123: 1488-1490
- Potential mechanisms of minoxidilinduced hair growth in alopecia areata.J Am Acad dermatol. 1987; 16: 653-656
- In situ demonstration of T-cells in alopecia areata.Arch dermatol. Res. 1982; 273: 155-158
- Immunohistochemical characterization of the cellular infiltrate in severe alopecia areata before and after minoxidil treatment.dermatologica. 1987; 175: 29-35
- Response to minoxidil in severe alopecia areata correlates with T-lymphocyte stimulation.Br J dermatol. 1987; 117: 759-763
- Alopecia areata and control lymphocyte blastogenesis suppressed by in vitro minoxidil.J Invest dermatol. 1986; 87: 139
- Separation of leukocytes from blood and bone marrow.Scand J Clin Lab Invest. 1968; 21: 77-109
- Minoxidil sulfate and sulfotransferase activity in alopecia areata.Clinical Research. 1987; 35: 682A
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© 1988 Published by Elsevier Inc.
