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Abstract
Although the mechanisms of follicular regression in androgenetic alopecia are not
fully understood, retinoids may be important in changing the status of regressing
follicles. There are many reports documenting reversal of epithelial dysplastic changes
with retinoids. 13–18 Although none of the studies with retinoids have concentrated on the precise mechanisms
of follicular growth (regression or regeneration), these limited observations1plt12
and our early studies2 suggest that further work should be done on the effect retinoids
have on the hair follicle during the various growth and regression phases of the follicular
life cycle in humans.
We propose that certain retinoids increase the rate of hair growth, prolong the anagen
phase of the hair cycle, play a role in converting vellus to terminal hairs, and act
synergistically with minoxidil to produce more dense hair regrowth from regressing
follicles than either compound alone. Larger controlled studies and better methods
for assessing hair growth are necessary to support these early results, Other retinoids
as well as certain minoxidil analogs should also be studied.
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References
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© 1988 Published by Elsevier Inc.
