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Abstract
In dealing with the biochemical mechanisms associated with hair growth, it is important
to delineate areas where our knowledge is lacking. Indeed, despite enormous literature
that has accumulated over many years, the hair follicle is still a “black box” in
terms of what we know of molecular events in hair growth. Regions of the follicle
under discussion herein are shown in Figure 4-1 in the color section. At a rate of
growth of approximately 300 μm per day, a hair cell would take 5 days to migrate from
the bulb region and emerge as a keratinized cell. At the end of the period of keratin
synthesis (indicated in red) the -SH content of the proteins is rapidly lowered to
the level (approximately 30 μmoles/g) found in the keratinized hair, by oxidation
to disulfide bonds. The oxidized state is reached over a period of 6–12 hours.
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© 1988 Published by Elsevier Inc.
