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In dealing with the biochemical mechanisms associated with hair growth, it is important to delineate areas where our knowledge is lacking. Indeed, despite enormous literature that has accumulated over many years, the hair follicle is still a “black box” in terms of what we know of molecular events in hair growth. Regions of the follicle under discussion herein are shown in Figure 4-1 in the color section. At a rate of growth of approximately 300 μm per day, a hair cell would take 5 days to migrate from the bulb region and emerge as a keratinized cell. At the end of the period of keratin synthesis (indicated in red) the -SH content of the proteins is rapidly lowered to the level (approximately 30 μmoles/g) found in the keratinized hair, by oxidation to disulfide bonds. The oxidized state is reached over a period of 6–12 hours.
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- Proliferation of follicle matrix cells in relation to wool growth.in: Lyne AG Short BF Biology of the Skin and Hair Growth. Angus and Robertson, Sydney1965: 409-426
- Cell proliferation and cortical cell production in relation to wool growth.Aust J Biol Sci. 1979; 32: 317-327
- An approach to the investigation of protein biosynthesis in hair follicles.in: Lyne AG Short BF Biology of the Skin and Hair Growth. Angus and Robertson, Sydney1965: 329-343
- The synthesis of hair keratin proteins in vitro.Biochem Biophys Acta. 1971; 238: 150-155
- In vitro studieson the synthesis of guinea pig hair keratin proteins.Biochem Biophys Acta. 1973; 312: 403-412
- Histological and biochemical features of the wool fibre and follicle.in: Black HL Reis PJ Physiological and Environmental Limitations to Wool Growth. NSW, University of New England Publishing Unit, Armidale1979: 193-208
- Ribonucleic acids coding for the keratin complex of hair.in: Orfanos CE Montagna W Stuttgen G Hair Research, Status and Future Aspects. Springer-Verlag, Berlin1981: 84-93
- The isolation of wool keratin messenger RNA from sheep.J Invest Dermatol. 1980; 75: 244-247
- Hair kerat, composition, structure and biogenesis.in: 4th ed. Biology of the Integument. 2. Springer-Verlag, Berlin1986: 695-721
- Molecular mechanisms in the formation of hair.in: Kobori T Montagna W Biology and Disease of the Hair. University of Tokyo Press, Tokyo1976: 411-435
- Electron microscope studies of hair and wool.Ann NY Acad Sci. 1959; 83: 378-399
- The localization of dehydrogenase activity and sulphydryl groups in wool and hair follicles by the use of tetrazolium salts.Quarterly Journal of Microscopic Science. 1953; 94: 253-268
- The structural proteins of hair: isolation, characterization and regulation of biosynthesis.in: Goldsmith LA Biochemistry and Physiology of the Skin. Oxford University Press, New York1983: 475-510
- Steely hair, mottled mice and copper metabolism.N Engl J Med. 1975; 293: 1147-1149
- Nutrition and wool production.in: Bird CL Fibrous Proteins: Proceedings of a Symposium at University of Leeds on May 23–25, 1946. Society of Dyers and Colourists, Leeds1946: 207-214
- Skin sulfhydryl oxidase. Purification and some properties.Biochem Biophys Acta. 1980; 615: 309-323
- Cystine-alkali reactions in relation to protein cross-linking.in: 4th ed. Advances in Experimental Medicine and Biology. 86B. Plenum Press, New York1977: 93-121
- ε-(-γ-glutamyl) lysine crosslinkage in citrulline-containing protein fractions from hair.Biochemistry. 1971; 10: 624-630
- Formation of the ε-(γ-glutamyl) lysine cross-link in hair proteins. Investigation of transamidases in hair follicles.Biochemistry. 1972; 11: 2858-2863
- The occurrence of citrulline structural proteins of the hair follicle.in: Goldsmith LA Biochemistry and Physiology of the Skin. Oxford University Press, New York1983: 511-521
- Trichohyalin, an intermediate filament associated protein of the hair follicle.J Cell Biol. 1986; 102: 1419-1429
© 1988 Published by Elsevier Inc.