Clinics in Dermatology
Volume 28, Issue 5 , Pages 533-538 , September 2010

Origins of syphilis and management in the immunocompetent patient: Facts and controversies

  • David Farhi, MD

      Affiliations

    • Department of Dermatology and Venereology, UPRES1833 Centre National de Reference de la Syphilis, Pavillon Tarnier, Hôpital Cochin, APHP, Université Paris V, 89 rue d'Assas, 75006 Paris, France
    • Corresponding Author InformationCorresponding author. Cabinet de dermatologie médicale et chirurgicale, 7 rue Coypel, 75013 Paris, France. Tel.: +33 1 42 17 07 37; fax: +33 1 58 41 28 95.
    • ,
  • Nicolas Dupin, MD

      Affiliations

    • Laboratoire de Recherche en Dermatologie, Hôpital Cochin—Pavillon Gustave Roussy Université Paris V—Faculté de médecine, 89 rue d'Assas, 75006 Paris, France

References 

  1. Knell RJ. Syphilis in renaissance Europe: rapid evolution of an introduced sexually transmitted disease?. Proc Biol Sci. 2004;271(suppl 4):S174–S176
  2. Rothschild BM. History of syphilis. Clin Infect Dis. 2005;40:1454–1463
  3. French P. Syphilis. BMJ. 2007;334:143–147
  4. Ghanem KG, Erbelding EJ, Wiener ZS, et al. Serological response to syphilis treatment in HIV-positive and HIV-negative patients attending sexually transmitted diseases clinics. Sex Transm Infect. 2007;83:97–101
  5. Rolfs RT, Joesoef MR, Hendershot EF, et al. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. N Engl J Med. 1997;337:307–314
  6. Quetel C. The history of syphilis. Baltimore: Johns Hopkins Press; 1990;
  7. Powell M, Cook D. The myth of syphilis: the natural history of treponematosis in North America. Gainesville: University Press of Florida; 2005;
  8. Fraser CM, Norris SJ, Weinstock GM, et al. Complete genome sequence of Treponema pallidum, the syphilis spirochete. Science. 1998;281:375–388
  9. Harper KN, Ocampo PS, Steiner BM, et al. On the origin of the treponematoses: a phylogenetic approach. PLoS Negl Trop Dis. 2008;2:e148
  10. Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep. 2006;55:1–94
  11. Buffet M, Grange PA, Gerhardt P, et al. Diagnosing Treponema pallidum in secondary syphilis by PCR and immunohistochemistry. J Invest Dermatol. 2007;127:2345–2350
  12. British Association for Sexual Health and HIV  Clinical Effectiveness Group. UK national guidelines on the management of syphilis 2008. 2008;Available at: http://www.bashh.org/documents/1771Accessed Feb 8, 2008
  13. Palmer HM, Higgins SP, Herring AJ, et al. Use of PCR in the diagnosis of early syphilis in the United Kingdom. Sex Transm Infect. 2003;79:479–483
  14. Koek AG, Bruisten SM, Dierdorp M, et al. Specific and sensitive diagnosis of syphilis using a real-time PCR for Treponema pallidum. Clin Microbiol Infect. 2006;12:1233–1236
  15. Goh BT. Syphilis in adults. Sex Transm Infect. 2005;81:448–452
  16. Farhi D, Dupin N. Serological diagnosis of syphilis. Ann Dermatol Venereol. 2008;135:418–425quiz 7, 26
  17. Schmidt BL, Edjlalipour M, Luger A. Comparative evaluation of nine different enzyme-linked immunosorbent assays for determination of antibodies against Treponema pallidum in patients with primary syphilis. J Clin Microbiol. 2000;38:1279–1282
  18. Medicines and Healthcare Products Regulatory Agency . MHRA 04109. Ten syphilis EIAs. 2004;Available at: http://www.hpa-midas.org.uk/documents/reports/Syphilis/MHRA_04109%20(Ten%20syphilis%20EIAs).pdfAccessed Sep 10, 2008
  19. Lewis DA, Young H. Syphilis. Sex Transm Infect. 2006;82(suppl 4):iv13–iv15
  20. Laboratory-based evaluation of rapid syphilis diagnostics. Results from 8 SDI Sites. WHO 2003. Available at: http://www.who.int/tdr/cd_publications/pdf/sdi.pdf. Accessed Sep 10, 2008.
  21. Egglestone SI, Turner AJ. Serological diagnosis of syphilis. PHLS Syphilis Serology Working Group. Commun Dis Public Health. 2000;3:158–162
  22. Lukehart SA, Hook EW, Baker-Zander SA, et al. Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment. Ann Intern Med. 1988;109:855–862
  23. Marra CM, Tantalo LC, Maxwell CL, et al. Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIV-infected individuals. Neurology. 2004;63:85–88
  24. Marra CM, Maxwell CL, Smith SL, et al. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features. J Infect Dis. 2004;189:369–376
  25. Libois A, De Wit S, Poll B, et al. HIV and syphilis: when to perform a lumbar puncture. Sex Transm Dis. 2007;34:141–144
  26. Goh BT, van Voorst Vader PC. European guideline for the management of syphilis. Int J STD AIDS. 2001;12(suppl 3):14–26
  27. Poliseli R, Vidal JE, Penalva De Oliveira AC, et al. Neurosyphilis in HIV-infected patients: clinical manifestations, serum venereal disease research laboratory titers, and associated factors to symptomatic neurosyphilis. Sex Transm Dis. 2008;35:425–429
  28. van Voorst Vader PC. Syphilis management and treatment. Dermatol Clin 1998;16:699-711, xi.
  29. Rolfs RT. Treatment of syphilis, 1993. Clin Infect Dis. 1995;20(suppl 1):S23–S38
  30. Perdrup A, Jorgensen BB, Pedersen NS. The profile of neurosyphilis in Denmark. A clinical and serological study of all patients in Denmark with neurosyphilis disclosed in the years 1971-1979 incl. by Wassermann reaction (CWRM) in the cerebrospinal fluid. Acta Derm Venereol Suppl (Stockh). 1981;96:1–14
  31. van Eijk RV, Wolters EC, Tutuarima JA, et al. Effect of early and late syphilis on central nervous system: cerebrospinal fluid changes and neurological deficit. Genitourin Med. 1987;63:77–82
  32. Madiedo G, Ho KC, Walsh P. False-positive VDRL and FTA in cerebrospinal fluid. JAMA. 1980;244:688–689
  33. Luger AF, Schmidt BL, Kaulich M. Significance of laboratory findings for the diagnosis of neurosyphilis. Int J STD AIDS. 2000;11:224–234
  34. Danbolt N, Clark EG, Gjestland T. The Oslo study of untreated syphilis; a re-study of the Boeck-Bruusgaard material concerning the fate of syphilitics who receive no specific treatment; a preliminary report. Acta Derm Venereol. 1954;34:34–38
  35. Lukehart SA. Serologic testing after therapy for syphilis: is there a test for cure?. Ann Intern Med. 1991;114:1057–1058
  36. Brown ST, Zaidi A, Larsen SA, et al. Serological response to syphilis treatment. A new analysis of old data. JAMA. 1985;253:1296–1299
  37. Fiumara NJ. Treatment of early latent syphilis of less than a year's duration: an evaluation of 275 cases. Sex Transm Dis. 1978;5:85–88
  38. Fiumara NJ. Treatment of secondary syphilis: an evaluation of 204 patients. Sex Transm Dis. 1977;4:96–99
  39. Fiumara NJ. Treatment of seropositive primary syphilis: an evaluation of 196 patients. Sex Transm Dis. 1977;4:92–95
  40. Romanowski B, Sutherland R, Fick GH, et al. Serologic response to treatment of infectious syphilis. Ann Intern Med. 1991;114:1005–1009
  41. Smith NH, Musher DM, Huang DB, et al. Response of HIV-infected patients with asymptomatic syphilis to intensive intramuscular therapy with ceftriaxone or procaine penicillin. Int J STD AIDS. 2004;15:328–332

PII: S0738-081X(10)00035-0

doi: 10.1016/j.clindermatol.2010.03.011

Clinics in Dermatology
Volume 28, Issue 5 , Pages 533-538 , September 2010

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