Clinics in Dermatology
Volume 28, Issue 5 , Pages 489-496, September 2010

Skin diseases associated with hepatitis C virus: Facts and controversies

  • Alfredo Rebora, MD

      Affiliations

    • Corresponding Author InformationTel.: +39 010 353 8414; fax: +39 010 353 8401.

Department of Endocrinological and Medical Sciences, Section of Dermatology, University of Genoa. Viale Benedetto XV, 7 –16132 Genova, Italy

Abstract 

Hepatitis C virus (HCV) is a common infectious agent and may induce several systemic disorders like mixed cryoglobulinemia. In the geographic areas where HCV infection is hyperendemic, HCV is the predominant etiologic factor for porphyria cutanea tarda and lichen planus. Vasculitides and autoimmune disorders, such as sicca syndrome, are probably often related to the virus. Interferon-a2b, which is largely used in the treatment of HCV-positive patients, may induce cell-mediated autoimmune side effects. Dermatologists may help to identify those patients timely.

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PII: S0738-081X(10)00028-3

doi:10.1016/j.clindermatol.2010.03.004

Clinics in Dermatology
Volume 28, Issue 5 , Pages 489-496, September 2010

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