Clinics in Dermatology
Volume 27, Issue 5 , Pages 495-501 , September 2009

Clinical and cosmeceutical uses of hydroxyacids

  • Barbara A. Green, RPh, MS

      Affiliations

    • NeoStrata Company, Inc, 307 College Road, Princeton, NJ 08540, USA
    • Corresponding Author InformationCorresponding author.
    • ,
  • Ruey J. Yu, PhD, OMD

      Affiliations

    • 655 Stump Road, Chalfont, PA 18914 USA
    • ,
  • Eugene J. Van Scott, MD

      Affiliations

    • 3 Hidden Lane, Abington, PA 19001 USA

References 

  1. Yu RJ, Van Scott EJ. α-hydroxyacids, polyhydroxy acids, aldobionic acids and their topical actions. In:  Baran R,  Maibach HI editor. Textbook of cosmetic dermatology. 3rd ed.. New York: Taylor & Francis; 2005;p. 77–93
  2. Van Scott EJ, Yu RJ. Control of keratinization with α-hydroxy acids and related compounds. Arch Dermatol. 1974;110:586–590
  3. Van Scott EJ, Yu RJ. Hyperkeratinization, corneocyte cohesion, and alpha hydroxyacids. J Am Acad Dermatol. 1984;11:867–879
  4. Ditre CM, Griffin TD, Murphy GF, et al. Effects of α-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. J Am Acad Dermatol. 1996;34:187–195
  5. Bernstein EF, Underhill CB, Lakkakorpi J, et al. Citric acid increases viable epidermal thickness and glycosaminoglycan content of sun-damaged skin. Dermatol Surg. 1997;23:689–694
  6. Berardesca E, Distante F, Vignoli GP, et al. Alpha hydroxyacids modulate stratum corneum barrier function. Br J Dermatol. 1997;137:934–938
  7. Bernstein EF, Green BA, Edison B, et al. Poly hydroxy acids (PHAs): clinical uses for the next generation of hydroxy acids. Skin Aging. 2001;9(suppl):4–11
  8. Edison BL, Green BA, Wildnauer RH, et al. A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen. Cutis. 2004;73(suppl 2):14–17
  9. Bernstein EF, Brown DB, Schwartz MD, et al. The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging. Dermatol Surg. 2004;30:1–8
  10. Kakita LS, Green BA. A review of the physical and chemical properties of alpha-hydroxyacids (AHAs) and polyhydroxy acids (PHAs) and their therapeutic use in pharmacologics. J Am Acad Dermatol. 2006;54:AB107
  11. Briden E, Jacobsen E, Johnson C. Combining superficial glycolic acid (AHA) peels with microdermabrasion to maximize treatment results and patient satisfaction. Cutis. 2007;79(suppl 1):13–16
  12. Charloux C, Paul M, Loisance D, et al. Inhibition of hydroxyl radical production by lactobionate, adenine, and tempol. Free Radical Bio Med. 1995;19:699–704
  13. Briden ME, Green BA. The next generation hydroxyacids. In:  Draelos ZD,  Dover J,  Alam M editor. Procedures in cosmetic dermatology: cosmeceuticals. Philadelphia: Elsevier Saunders; 2005;p. 205–212
  14. Upadhya GA, Strasberg SM. Glutathione, lactobionate, and histidine: cryptic inhibitors of matrix metalloproteinases contained in University of Wisconsin and histidine/tryptophan/ketoglutarate liver preservation solutions. Hepatology. 2000;31:1115–1122
  15. Thibodeau A. Metalloproteinase inhibitors. Cosmet Toilet. 2000;115:75–76
  16. Rizer R, Turcott A, Edison B, et al. An evaluation of the tolerance profile of a complete line of gluconolactone-containing skin care formulations in atopic individuals. Skin Aging. 2001;9(suppl):18–21
  17. Rizer R, Turcott A, Edison B, et al. An evaluation of the tolerance profile of gluconolactone-containing skin care formulations in individuals with rosacea. Skin Aging. 2001;9(suppl):22–25
  18. Draelos ZD, Green BA, Edison BL. An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients. J Cosmet Dermatol. 2006;5:23–29
  19. Van Scott EJ, Yu RJ. Actions of alpha hydroxy acids on skin compartments. J Geriatr Dermatol. 1995;3(suppl A):19–24
  20. Kim SJ, Park JH, Kim DH, et al. Increased in vivo collagen synthesis and in vitro cell proliferative effect of glycolic acid. Dermatol Surg. 1998;24:1054–1058
  21. Bernstein EF, Lee J, Brown DB, et al. Glycolic acid treatment increases type I collagen mRNA and hyaluronic acid content of human skin. Dermatol Surg. 2001;27:1–5
  22. Green BA, Edison BL, Wildnauer RH, et al. Lactobionic acid and gluconolactone: PHAs for photoaged skin. Cosmet Dermatol. 2001;9:24–28
  23. Van Scott EJ, Ditre CM, Yu RJ. Alpha-hydroxyacids in the treatment of signs of photoaging. Clin Dermatol. 1996;14:217–226
  24. Lavker RM, Kaidbey K, Leyden J. Effects of topical ammonium lactate on cutaneous atrophy from a potent topical corticosteroid. J Am Dermatol. 1992;26:535–544

PII: S0738-081X(09)00156-4

doi: 10.1016/j.clindermatol.2009.06.023

Clinics in Dermatology
Volume 27, Issue 5 , Pages 495-501 , September 2009

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