Clinics in Dermatology
Volume 27, Issue 5 , Pages 479-484, September 2009

Cosmeceuticals and silibinin

  • Rana P. Singh, PhD

      Affiliations

    • Cancer Biology Laboratory, 104 School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    • Corresponding Author InformationCorresponding authors. Tel.: +91 1126704503; fax: +91 1126742558 (R.P. Singh); Tel.: +1 303 315 1381; fax: +1 303 315 6281 (R. Agarwal).
    • ,
  • Rajesh Agarwal, PhD

      Affiliations

    • Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, C238- P15, Research 2, Room 3121, 12700 19th Avenue, Aurora, CO 80045, USA
    • Corresponding Author InformationCorresponding authors. Tel.: +91 1126704503; fax: +91 1126742558 (R.P. Singh); Tel.: +1 303 315 1381; fax: +1 303 315 6281 (R. Agarwal).

Abstract 

Cosmeceuticals are used for nourishing and improving the appearance of the skin and are also documented as effective agents for treating various dermatologic conditions. Cosmeceutical preparations from herbal origin are most popular among consumers because these agents are mostly nontoxic and possess strong antioxidant activity. Because oxidative stress is one of the major mechanisms for skin aging and dermatologic conditions, phytochemicals with proven antioxidant activity, such as silibinin, could be useful for treating many dermatologic conditions as well as skin aging. Silibinin is a flavonolignan compound from Silybum marianum (milk thistle plant) that possesses strong antioxidant activity and also modulates many molecular changes caused by xenobiotics and ultraviolet radiation to protect the skin. This contribution reviews the evidence generated from laboratory studies to support the scientific rationale for the effective use of silibinin in cosmeceutical preparations.

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PII: S0738-081X(09)00127-8

doi:10.1016/j.clindermatol.2009.05.012

Clinics in Dermatology
Volume 27, Issue 5 , Pages 479-484, September 2009

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