Clinics in Dermatology
Volume 27, Issue 6 , Pages 564-587 , November 2009

Unusual variants of malignant melanoma

  • Raymond L. Barnhill, MD

      Affiliations

    • Departments of Dermatology and Pathology, Hôpital Saint-Louis and University of Paris VII, 1, Avenue Claude-Vellefaux, 75010 Paris, France
    • Corresponding Author InformationCorresponding author.
  • ,
  • Kapil Gupta, MD

      Affiliations

    • Dermatology Group of the Carolinas, Concord, NC 28025, USA

References 

  1. Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353:2135–2147
  2. Bruijn JA, Salasche S, Sober AJ, Mihm MC, Barnhill RL. Desmoplastic melanoma: clinicopathologic aspects of six cases. Dermatology. 1992;185:3–8
  3. Carlson JA, Dickersin GR, Sober AJ, Barnhill RL. Desmoplastic neurotropic malignant melanoma: a clinicopathologic analysis of 28 cases. Cancer. 1994;75:478–494
  4. Tsao H, Sober AJ, Barnhill RL. Desmoplastic neurotropic melanoma. Semin Cutan Med Surg. 1997;16:131–136
  5. Penneys NS. Excision of melanoma after initial biopsy. An immunohistochemical study. J Am Acad Dermatol. 1985;13:995–998
  6. Chorny JA, Barr RJ. S100-positive spindle cells in scars: a diagnostic pitfall in the re-excision of desmoplastic melanoma. Am J Dermatopathol. 2002;24:309–312
  7. Robson A, Allen P, Hollowood K. S100 expression in cutaneous scars: a potential diagnostic pitfall in the diagnosis of desmoplastic melanoma. Histopathology. 2001;38:135–140
  8. Winnepenninckx V, De Vos R, Stas M, van den Oord JJ. New phenotypical and ultrastructural findings in spindle cell (desmoplastic/neurotropic) melanoma. Appl Immunohistochem Mol Morphol. 2003;11:319–325
  9. Lens MB, Newton-Bishop JA, Boon AP. Desmoplastic malignant melanoma: a systematic review. Br J Dermatol. 2005;152:673–678
  10. Cummins DL, Esche C, Barrett TL, et al. Lymph node biopsy results for desmoplastic malignant melanoma. Cutis. 2007;79:390–394
  11. Posther KE, Selim MA, Mosca PJ, et al. Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma. Ann Surg Oncol. 2006;13:728–739
  12. Quinn MJ, Crotty KA, Thompson JF, et al. Desmoplastic and desmoplastic neurotropic melanoma: experience with 280 patients. Cancer. 1998;83:1128–1135
  13. Skelton HG, Smith KJ, Laskin WB, et al. Desmoplastic malignant melanoma. J Am Acad Dermatol. 1995;32:717–725
  14. Livestro DP, Muzikansky A, Kaine EM, et al. Biology of desmoplastic melanoma: a case-control comparison with other melanomas. J Clin Oncol. 2005;23:6739–6746
  15. Hawkins WG, Busam KJ, Ben-Porat L, et al. Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma. Ann Surg Oncol. 2005;12:207–213
  16. Barnhill R. Malignant melanoma. In:  Barnhill R,  Piepkorn M,  Busam KJ editor. Pathology of melanocytic nevi and malignant melanoma. 2nd ed.. New York: Springer Verlag; 2004;p. 303–311
  17. Wong TY, Duncan LM, Mihm MC. Melanoma mimicking dermal and Spitz's nevus (“nevoid” melanoma). Semin Surg Oncol. 1993;9:188–193
  18. Vollmer RT. Use of Bayes rule and MIB-1 proliferation index to discriminate Spitz nevus from malignant melanoma. Am J Clin Pathol. 2004;122:499–505
  19. Kapur P, Selim MA, Roy LC, Yegappan M, Weinberg AG, Hoang MP. Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. Mod Pathol. 2005;18:197–204
  20. Kanter-Lewensohn L, Hedblad MA, Wejde J, et al. Immunohistochemical markers for distinguishing Spitz nevi from malignant melanomas. Mod Pathol. 1997;10:917–920
  21. Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol. 2000;157:967–972
  22. Healy E, Belgaid C, Takata M, et al. Allelotypes of primary cutaneous melanoma and benign melanocytic nevi. Cancer Res. 1996;56:589–593
  23. Bogdan I, Burg G, Boni R. Spitz nevi display allelic deletions. Arch Dermatol. 2001;137:1417–1420
  24. Gill M, Cohen J, Renwick N, et al. Genetic similarities between Spitz nevus and Spitzoid melanoma in children. Cancer. 2004;101:2636–2640
  25. Davies H, Bignell GH, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417:949–954
  26. Pollock PM, Harper UL, Hansen KS, et al. High frequency of BRAF mutations in nevi. Nat Genet. 2003;33:19–20
  27. Barnhill RL. The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma’ and risk assessment. Mod Pathol. 2006;19:S21–S33
  28. Murali R, Sharma RN, Thompson JF, et al. Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors). Ann Surg Oncol. 2008;15:302–309
  29. Barnhill RL, Lugassy C. Angiotropic malignant melanoma and extravascular migratory metastasis: description of 36 cases with emphasis on a new mechanism of tumour spread. Pathology. 2004;36:485–490
  30. Lugassy C, Barnhill RL. Angiotropic malignant melanoma and extravascular migratory metastasis: a review. Adv Anat Pathol. 2007;14:195–201
  31. Lugassy C, Eyden BP, Christensen L, Escande JP. Angio-tumoral complex in human malignant melanoma characterised by free laminin: ultrastructural and immuno-histochemical observations. J Submicrosc Cytol Pathol. 1997;29:19–28
  32. Lugassy C, Dickersin GR, Christensen L, et al. Ultrastructural and immunohistochemical studies of the periendothelial matrix in malignant melanoma: evidence for an amorphous matrix containing laminin. J Cutan Pathol. 1999;26:78–83
  33. Lugassy C, Shahsafaei A, Bonitz P, Busam KJ, Barnhill RL. Tumor microvessels in melanoma express the beta-2 chain of laminin. Implications for melanoma metastasis. J Cutan Pathol. 1999;26:222–226
  34. Barnhill R, Dy K, Lugassy C. Angiotropism in cutaneous melanoma: a prognostic factor strongly predicting risk for metastasis. J Invest Dermatol. 2002;119:705–706
  35. Lugassy C, Vernon SE, Busam K, et al. Angiotropism of human melanoma: Studies involving in transit and other cutaneous metastases and the chicken chorioallantoic membrane: Implications for extravascular melanoma invasion and metastasis. Am J Dermatopathol. 2006;28:187–193
  36. Lugassy C, Haroun RI, Brem H, et al. Pericytic-like angiotropism of glioma and melanoma cells. Am J Dermatopathol. 2002;24:473–478
  37. Lugassy C, Kleinman HK, Fernandez PM, et al. Human melanoma cell migration along capillary-like structures in vitro: a new dynamic model for studying extravascular migratory metastasis. J Invest Dermatol. 2002;119:703–704
  38. Lugassy C, Kleinman HK, Vernon SE, Welch DR, Barnhill RL. C16 laminin peptide increases angiotropic extravascular migration of human melanoma cells in a shell-less chick cam assay. Br J Dermatol. 2007;157:780–782
  39. Allen AC: A reorientation on the histogenesis and clinical significance of cutaneous nevi and melanomas. Cancer. 1949;2:28–56
  40. Temple-Camp CRE, Saxe N, King H. Benign and malignant cellular blue nevus. A clinicopathological study of 30 cases. Am J Dermatopathol. 1988;10:289–296
  41. Goldenhersh MA, Savin RC, Barnhill RL, Stenn KS. Malignant blue nevus. J Am Acad Dermatol. 1988;19:712–722
  42. Connelly J, Smith JL. Malignant blue nevus. Cancer. 1991;67:2653–2657
  43. Granter SR, McKee PH, Calonje E, Mihm MC, Busan K. Melanoma associated with blue nevus and melanoma mimicking cellular blue nevus: a clinicopathologic study of 10 cases on the spectrum of so-called “malignant blue nevus.”. Am J Surg Pathol. 2001;25:316–323
  44. Rodriguez HA, Ackerman LV. Cellular blue nevus. Clinicopathologic study of forty-five cases. Cancer. 1968;21:393–405
  45. Tran TA, Carlson JA, Basaca B, Mihm MC. Cellular blue nevus with atypia (atypical cellular blue nevus): a clinicopathologic study of nine cases. J Cutan Pathol. 1998;25:252–258
  46. Barnhill R. Malignant melanoma. In:  Barnhill R,  Piepkorn M,  Busam KJ editor. Pathology of melanocytic nevi and malignant melanoma. 2nd ed.. New York: Springer Verlag; 2004;p. 322–328
  47. Maize JC, McCalmont TH, Carlson JA, Busam KJ, Kutzner H, Bastian BC. Genomic analysis of blue nevi and related dermal melanocytic proliferations. Am J Surg Pathol. 2005;29:1214–1220
  48. Barnhill RL, Argenyi Z, Berwick M, et al. Atypical cellular blue nevi (cellular blue nevi with atypical features): lack of consensus for diagnosis and distinction from cellular blue nevi and malignant melanoma (“malignant blue nevus”). Am J Surg Pathol. 2008;32:36–44

PII: S0738-081X(08)00192-2

doi: 10.1016/j.clindermatol.2008.09.015

Clinics in Dermatology
Volume 27, Issue 6 , Pages 564-587 , November 2009