Clinics in Dermatology
Volume 27, Issue 6 , Pages 545-555 , November 2009

Spitzoid melanoma

References 

  1. Crotty KA, Scolyer RA, Li L, et al. Spitz naevus versus Spitzoid melanoma: when and how can they be distinguished?. Pathology. 2002;34:6–12
  2. Barnhill RL, Argenyi ZB, From L, et al. Atypical Spitz nevi/tumors: lack of consensus for diagnosis, discrimination for melanoma, and prediction of outcome. Hum Pathol. 1999;30:513–520
  3. Ruiter DJ, van Dijk MC, Ferrier CM. Current diagnostic problems in melanoma pathology. Semin Cutan Med Surg. 2003;22:33–41
  4. Lodha S, Saggar S, Celebi JT, et al. Discordance in the histopathologic diagnosis of difficult melanocytic neoplasms in the clinical setting. J Cutan Pathol. 2008;35:349–352
  5. Barnhill RL. The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma’ and risk assessment. Mod Pathol. 2006;19(Suppl 2):S21–S33
  6. Elder DE, Xu X. The approach to the patient with a difficult melanocytic lesion. Pathology. 2004;36:428–434
  7. Troxel DB. Medico legal aspects of error in pathology. Arch Pathol Lab Med. 2006;130:617–619
  8. High WA. Malpractice in dermatopathology-principles, risk mitigation, and opportunitieis for improved care for the histologic diagnosis of melanoma and pigmented lesions. Clin Lab Med. 2008;28:261–284
  9. Reed RJ, Ichinose H, Clark WH, et al. Common and uncommon melanocytic nevi and borderline melanomas. Semin Oncol. 1975;2:119–127
  10. Phillips ME, Margolis RJ, Merot I, et al. The spectrum of minimal deviation melanoma: a clinicopathologic study of 21 cases. Hum Pathol. 1986;17:796–806
  11. Smith KJ, Barrett TL, Skelton HG, et al. Spindle cell and epithelioid cell nevi with atypia and metastasis (malignant Spitz nevus). Am J Surg Pathol. 1989;13:931–939
  12. Barnhill RL, Flotte T, Fleischli M, et al. Cutaneous melanoma and atypical Spitz tumors in childhood. Cancer. 1995;76:1833–1854
  13. Strouse JJ, Fears TR, Tucker MA, et al. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J Clin Oncol. 2005;23:4735–4741
  14. Huynh PM, Grant-Kels JM, Grin CM. Childhood melanomas: update and treatment. Int J Dermatol. 2005;44:715–723
  15. Spatz A, Ruiter D, Hardmeier T, et al. Melanoma in childhood: an EORTC-MCG multicenter study on the clinico-pathological aspects. Int J Cancer. 1996;68:317–324
  16. Mones JM, Ackerman AB. Melanomas in prepubescent children: review comprehensively, critique historically, criteria diagnostically, and course biologically. Am J Dermatopathol. 2003;25:223–238
  17. Crowson AN, Magro CM, Mihm MC. In: The melanocytic proliferations: a comprehensive textbook of pigmented lesions. New York: Wiley-Liss, Inc; 2001;p. 348
  18. Massi G, LeBoit P. Spitzoid melanoma. In: Histological diagnosis of nevi and melanoma. Heidelberg, Germany: Steinkopff-Verlag Darmstadt; 2004;p. 463–486
  19. Walsh N, Crotty K, Palmer A, et al. Spitz nevus versus spitzoid malignant melanoma: an evaluation of the current distinguishing histopathologic criteria. Hum Pathol. 1998;29:1105–1112
  20. Hantschke M, Bastian BC, LeBoit PE. Consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and Spitz nevus. Am J Surg Pathol. 2004;28:1621–1625
  21. Braun-Falco M, Friedrichson E, Ring J. Subepidermal cleft formation as a diagnostic marker for cutaneous malignant melanoma. Hum Pathol. 2005;36:412–415
  22. Kamino H, Misheloff E, Ackerman AB, et al. Eosinophilic globules in Spitz's nevi. New findings and a diagnostic sign. Am J Dermatopathol. 1979;1:319–324
  23. Bevona C, Goggins W, Quinn T, et al. Cutaneous melanomas associated with nevi. Arch Dermatol. 2003;139:1620–1624
  24. Kaddu S, Smolle J, Zenahlik P, et al. Melanoma with benign melanocytic naevus components: reappraisal of clinicopathological features and prognosis. Melanoma Res. 2002;12:271
  25. Smolle J, Kaddu S, Kerl H. Non-random spatial association of melanoma and naevi–a morphometric analysis. Melanoma Res. 1999;9:407–412
  26. Urso C, Giannotti V, Reali UM, et al. Spatial association of melanocytic naevus and melanoma. Melanoma Res. 1991;1:245–249
  27. Bergman R, Malkin L, Sabo E, et al. MIB-1 monoclonal antibody to determine proliferative activity of Ki-67 antigen as an adjunct to the histopathologic differential diagnosis of Spitz nevi. J Am Acad Dermatol. 2001;44:500–504
  28. Kapur P, Selim MA, Roy L, et al. Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis. Mod Pathol. 2005;18:197–204
  29. Ribe A, McNutt NS. S100A6 protein expression is different in Spitz nevi and melanomas. Mod Pathol. 2003;16:505–511
  30. King MS, Porchia SJ, Hiatt KM. Differentiating spitzoid melanomas from Spitz nevi through CD99 expression. J Cutan Pathol. 2007;34:576–580
  31. Bergman R, Dromi R, Trau H, et al. The pattern of HMB-45 antibody staining in compound Spitz nevi. Am J Dermatopathol. 1995;17:542–546
  32. McNutt NS, Urmacher C, Hakimian J, et al. Nevoid malignant melanoma: morphologic patterns and immunohistochemical reactivity. J Cutan Pathol. 1995;22:502–517
  33. Bastian BC, Wesselman U, Pinkel D, et al. Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma. J Invest Dermatol. 1999;113:1065–1069
  34. Bastian BC, LeBoit PE, Pinkel D. Mutations and copy number increases of HRAS in Spitz nevi with distinctive histopathologic features. Am J Pathol. 2000;157:967–972
  35. Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353:2135–2147
  36. Bastian BC, LeBoit PE, Hamm H, et al. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res. 1998;58:2170–2175
  37. Bauer J, Bastian BC. Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as research and diagnostic tool. Dermatol Ther. 2006;19:40–49
  38. Palmedo G, Hantschke M, Rutten A, et al. The T1796A mutation of the BRAF gene is absent in Spitz nevi. J Cutan Pathol. 2004;31:266–270
  39. Fullen DR, Poynter JN, Lowe L, et al. BRAF and RAS mutations in Spitzoid melanocytic lesions. Mod Pathol. 2006;19:1324–1332
  40. Lee DA, Cohen JA, Twaddell WS, et al. Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma. Cancer. 2006;106:907–913
  41. Spatz A, Calonje E, Handfield-Jones S, et al. Spitz tumors in children: a grading system for risk stratification. Arch Dermatol. 1999;135:282–285
  42. NIH consensus conference . Diagnosis and treatment of early melanoma. JAMA. 1992;268:1314–1319
  43. Veronesi U, Cascinelli N, Adams J, et al. Thin stage I primary cutaneous malignant melanoma. Comparison of excision with margins of 1 or 3 cm. N Engl J Med. 1988;318:1159–1162
  44. Balch CM, Urist MM, Karakousis CP, et al. Efficacy of 2 cm surgical margins for intermediate-tickness melanomas (1 to 4 mm): results of a multi-institutional randomized surgical trial. Ann Surg. 1993;218:262–267
  45. Lohmann C, Coit DG, Brady MS, et al. Sentinel lymph node biopsy in patients with diagnostically controversial spitzoid melanocytic tumors. Am J Surg Pathol. 2002;26:47–55
  46. Su LD, Fullen DR, Sondak VK, et al. Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions. A report of 18 patients. Cancer. 2003;97:499–507
  47. Murali R, Sharma RN, Thompson JF, et al. Sentinel lymph node biopsy in histologically ambiguous melanocytic tumors with spitzoid features (so-called atypical spitzoid tumors). Ann Surg Oncol. 2008;15:302–309
  48. Ferrari A, Bono A, Baldi M, et al. Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution. Pdiatrics. 2005;115:649–654
  49. Pol-Rodriguez M, Lee S, Silvers DN, et al. Influence of age on survival in childhood Spitzoid melanomas. Cancer. 2007;109:1579–1583
  50. Paniago-Pereira C, Maize JC, Ackerman AB. Nevus of large spindle and/ or epitheliod cells (Spitz's nevus). Arch Dermatol. 1978;114:1811–1823
  51. Weedon D, Little JH. Spindle and epithelioid cell nevi in children and adults: a review of 211 cases of the Spitz nevus. Cancer. 1977;40:217–225
  52. Toussaint S, Kamino H. Dysplastic changes in different types of melanocytic nevi. A unifying concept. J Cutan Pathol. 1999;26:84–90
  53. Harvell JD, Bastian BC, LeBoit PE. Persistent (recurrent) Spitz nevi. A histopathologic, immunohistochemical, and molecular pathologic study of 22 cases. Am J Surg Pathol. 2002;26:654–661
  54. Wong TY, Suster S, Duncan LM, et al. Nevoid melanoma: a clinicopathological study of seven cases of malignant melanoma mimicking spindle and epithelioid cell nevus and verrucous dermal nevus. Hum Pathol. 1995;26:171–179
  55. McNutt NS. “Triggered trap”: nevoid malignant melanoma. Semin Diagn Pathol. 1998;15:203–209
  56. Kornberg R, Harris M, Ackerman AB. Epidermotropically metastatic malignant melanoma. Differentiating malignant melanoma metastatic to the epidermis from malignant melanoma primary in the epidermis. Arch Dermatol. 1978;114:67–69
  57. Gerami P, Shea C, Stone M. Angiotropism in epidermotropic metastatic melanoma. Another clue to the diagnosis. Am J Dermatopathol. 2006;28:429–433

PII: S0738-081X(08)00190-9

doi: 10.1016/j.clindermatol.2008.09.013

Clinics in Dermatology
Volume 27, Issue 6 , Pages 545-555 , November 2009

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