Clinics in Dermatology
Volume 27, Issue 2 , Pages 202-209, March 2009

Melatonin: circadian rhythm regulator, chronobiotic, antioxidant and beyond

Institute of General Physiology and Biochemistry, “Giovanni Esposito”, University of Milan, Faculty of Pharmacy, Via Trentacoste 2, Milan 20134, Italy

Abstract 

For many years, melatonin has been known to interact with circadian rhythms.

New evidence indicates that melatonin acts as a free radical scavenger and antioxidant.

Moreover, melatonin prevents apoptosis in different types of cells, because it induces mRNA levels of several antioxidant enzymes.

It is evident that melatonin is involved in the cellular bioenergetic system as a mechanism that counteracts the progression of Alzheimer's disease.

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PII: S0738-081X(08)00072-2

doi:10.1016/j.clindermatol.2008.04.003

Clinics in Dermatology
Volume 27, Issue 2 , Pages 202-209, March 2009

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