Clinics in Dermatology
Volume 26, Issue 4 , Pages 358-363 , July 2008

Redox regulation of cellular stress response by ferulic acid ethyl ester in human dermal fibroblasts: role of vitagenes

  • Vittorio Calabrese, MD, PhD

      Affiliations

    • Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    • Corresponding Author InformationCorresponding authors. Vittorio Calabrese is to be contacted at Department of Chemistry, Biochemistry, and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. Pierfrancesco Morganti, Mavi Sud srl, Viale Dell’industria 1, 04011 Aprilia (LT), Italy.
    • ,
  • Stella Calafato, MD

      Affiliations

    • Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    • ,
  • Eduardo Puleo, PhD

      Affiliations

    • Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    • ,
  • Carolin Cornelius, PhD

      Affiliations

    • Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    • ,
  • Maria Sapienza, PhD

      Affiliations

    • Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    • ,
  • Pierfrancesco Morganti, MD, PhD

      Affiliations

    • Applied Cosmetic Dermatology, II University of Naples, Naples, Italy
    • Skin Pharmacology, China Medical University, Shenyang, China
    • Mavi Sud srl, Viale Dell'industria 1, 04011 Aprilia (LT), Italy
    • Corresponding Author InformationCorresponding authors. Vittorio Calabrese is to be contacted at Department of Chemistry, Biochemistry, and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy. Pierfrancesco Morganti, Mavi Sud srl, Viale Dell’industria 1, 04011 Aprilia (LT), Italy.
    • ,
  • Cesare Mancuso, MD, PhD

      Affiliations

    • Institute of Pharmacology, Catholic University School of Medicine, 00168 Roma, Italy

References 

  1. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84
  2. Karihtala P, Soini Y. Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies. APMIS. 2007;115:81–103
  3. Mancuso C, Scapagnini G, Currò D, et al. Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci. 2007;12:1107–1123
  4. Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol. 2006;126:2565–2575
  5. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160:1–40
  6. Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and its role in skin disease. Antioxid Redox Signal. 2002;4:665–673
  7. Calabrese V, Guagliano E, Sapienza M, et al. Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. Neurochem Res. 2007;32:757–773
  8. Calabrese V, Boyd-Kimball D, Scapagnini G, Butterfield DA. Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes. In Vivo. 2004;18:245–267
  9. Calabrese V, Butterfield DA, Scapagnini G, Stella AM, Maines MD. Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity. Antioxid Redox Signal. 2006;8:444–477
  10. Morris SD. Heat shock proteins and the skin. Clin Exp Dermatol. 2002;27:220–224
  11. Mancuso C. Heme oxygenase and its products in the nervous system. Antioxid Redox Signal. 2004;6:878–887
  12. Mancuso C, Pani G, Calabrese V. Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species. Redox Rep. 2006;11:207–213
  13. Mancuso C, Perluigi M, Cini C, De Marco C, Giuffrida Stella AM, Calabrese V. Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay. J Neurosci Res. 2006;84:1385–1391
  14. Gutsmann-Conrad A, Heydari AR, You S, Richardson A. The expression of heat shock protein 70 decreases with cellular senescence in vitro and in cells derived from young and old human subjects. Exp Cell Res. 1998;241:404–413
  15. Tyrrell RM, Reeve VE. Potential protection of skin by acute UVA irradiation—from cellular to animal models. Prog Biophys Mol Biol. 2006;92:86–91
  16. Tyrrell RM. Solar ultraviolet A radiation: an oxidizing skin carcinogen that activates heme oxygenase-1. Antioxid Redox Signal. 2004;6:835–840
  17. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983;65:55–63
  18. Sultana R, Ravagna A, Mohmmad-Abdul H, Calabrese V, Butterfield DA. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005;92:749–758
  19. Mohmmad Abdul H, Butterfield DA. Protection against amyloid beta-peptide (1-42)-induced loss of phospholipid asymmetry in synaptosomal membranes by tricyclodecan-9-xanthogenate (D609) and ferulic acid ethyl ester: implications for Alzheimer's disease. Biochim Biophys Acta. 2005;1741:140–148
  20. Scapagnini G, Butterfield DA, Colombrita C, Sultana R, Pascale A, Calabrese V. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004;6:811–818
  21. Kim HS, Cho JY, Kim DH, et al. Inhibitory effects of long-term administration of ferulic acid on microglial activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. Biol Pharm Bull. 2004;27:120–121
  22. Ogiwara T, Satoh K, Kadoma Y, et al. Radical scavenging activity and cytotoxicity of ferulic acid. Anticancer Res. 2002;22:2711–2717
  23. Kanski J, Aksenova M, Stoyanova A, Butterfield DA. Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J Nutr Biochem. 2002;13:273–281
  24. Kikuzaki H, Hisamoto M, Hirose K, Akiyama K, Taniguchi H. Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem. 2002;50:2161–2168
  25. Graf E. Antioxidant potential of ferulic acid. Free Radic Biol Med. 1992;13:435–448
  26. Saija A, Tomaino A, Trombetta D, et al. In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents. Int J Pharm. 2000;199:39–47
  27. Saija A, Tomaino A, Lo Cascio R, et al. Ferulic and caffeic acids as potential protective agents against photooxidative skin damage. J Sci Food Agric. 1999;79:476–480
  28. Perluigi M, Joshi G, Sultana R, et al. In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress. J Neurosci Res. 2006;84:418–426
  29. Joshi G, Perluigi M, Sultana R, Agrippino R, Calabrese V, Butterfield DA. In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. Neurochem Int. 2006;48:318–327
  30. Allanson M, Reeve VE. Immunoprotective UVA (320-400 nm) irradiation upregulates heme oxygenase-1 in the dermis and epidermis of hairless mouse skin. J Invest Dermatol. 2004;122:1030–1036
  31. Reeve VE, Tyrrell RM. Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse. Proc Natl Acad Sci U S A. 1999;96:9317–9321
  32. Allanson M, Reeve VE. Carbon monoxide signalling reduces photocarcinogenesis in the hairless mouse. Cancer Immunol Immunother. 2007;56:1807–1815
  33. Allanson M, Domanski D, Reeve VE. Photoimmunoprotection by UVA (320-400 nm) radiation is determined by UVA dose and is associated with cutaneous cyclic guanosine monophosphate. J Invest Dermatol. 2006;126:191–197
  34. Allanson M, Reeve VE. Ultraviolet A (320-400 nm) modulation of ultraviolet B (290-320 nm)-induced immune suppression is mediated by carbon monoxide. J Invest Dermatol. 2005;124:644–650
  35. Stocker R. Antioxidant activities of bile pigments. Antioxid Redox Signal. 2004;6:841–849
  36. Mancuso C, Bonsignore A, Capone C, Di Stasio E, Pani G. Albumin-bound bilirubin interacts with nitric oxide by a redox mechanism. Antioxid Redox Signal. 2006;8:487–494
  37. Mancuso C, Bonsignore A, Di Stasio E, Mordente A, Motterlini R. Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide. Biochem Pharmacol. 2003;66:2355–2363
  38. Topping A, Gault D, Grobbelaar A, et al. Successful reduction in skin damage resulting from exposure to the normal-mode ruby laser in an animal model. Br J Plast Surg. 2001;54:144–150
  39. Laplante AF, Moulin V, Auger FA, et al. Expression of heat shock proteins in mouse skin during wound healing. J Histochem Cytochem. 1998;46:1291–1301
  40. McMurtry AL, Cho K, Young LJ, Nelson CF, Greenhalgh DG. Expression of HSP70 in healing wounds of diabetic and nondiabetic mice. J Surg Res. 1999;86:36–41
  41. Kwon SB, Young C, Kim DS, et al. Impaired repair ability of hsp70.1 KO mouse after UVB irradiation. J Dermatol Sci. 2002;28:144–151

☆ The authors declare no conflict of interest.

PII: S0738-081X(08)00006-0

doi: 10.1016/j.clindermatol.2008.01.005

Clinics in Dermatology
Volume 26, Issue 4 , Pages 358-363 , July 2008

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