Clinics in Dermatology
Volume 26, Issue 4 , Pages 326-333 , July 2008

The multifunctional role of ectoine as a natural cell protectant

  • Ruediger Graf, PhD

      Affiliations

    • Department of Cosmetics and Food, Merck KGaA, 64293 Darmstadt, Germany
    • Corresponding Author InformationCorresponding author.
    • ,
  • Soheila Anzali, PhD

      Affiliations

    • R&D New Technology Evaluation, Merck KGaA, 64293 Darmstadt, Germany
    • ,
  • Joachim Buenger, PhD

      Affiliations

    • Department of Cosmetics and Food, Merck KGaA, 64293 Darmstadt, Germany
    • ,
  • Frank Pfluecker, PhD

      Affiliations

    • Department of Cosmetics and Food, Merck KGaA, 64293 Darmstadt, Germany
    • ,
  • Hansjuergen Driller, PhD

      Affiliations

    • Department of Cosmetics and Food, Merck KGaA, 64293 Darmstadt, Germany

References 

  1. Galinski EA. Compatible solutes of halophilic eubacteria: molecular principles, water-solute interaction, stress protection. Experienta. 1993;49:487–496
  2. Galinski EA, Stein M, Amendt B, Kinder M. The kosmotropic (structure-forming) effect of compensatory solutes. Comp Biochem Physiol. 1997;117A:357–365
  3. Kolp S, Pietsch M, Galinski EA, Guetschow M. Compatible solutes as protectants for zymogens against proteolysis. Biochim Biophys Acta. 2006;1764:1234–1242
  4. Goeller K, Galinski EA. Protection of a model enzyme (lactate dehydrogenase) against heat, urea and freeze-thaw treatment by compatible solute additives. J Mol Catal B Enzym. 1999;7:37–45
  5. Yu I, Nagaoka M. Slowdown of water diffusion around protein in aqueous solution with ectoine. Chem Phys Lett. 2004;388:316–321
  6. Crowe JH, Carpenter JF, Crowe LM, Anchordoguy TJ. Are freezing and dehydration similar stress vectors? A comparison of modes of interaction of stabilizing solutes with biomolecules. Cryobiology. 1990;27:219–231
  7. Schobert B, Tschesche H. Unusual solution properties of praline and its interaction with proteins. Biochem Biophys Acta. 1978;541:270–277
  8. Wiggins PM. Role of water in some biology processes. Microbiol Rev. 1990;54:432–449
  9. Lippert K, Galinski EA. Enzyme stabilization by ectoine-type compatible solutes: protection against heating, freezing and drying. Appl Microbiol Biotechnol. 1992;37:61–65
  10. Lentzen G, Schwarz T. Extremolytes: natural compounds from extremophiles for versatile applications. Appl Microbiol Biotechnol. 2006;72:623–634
  11. Orth DS, Appa Y. Glycerine: a natural ingredient for moisturizing skin. In:  Loden M,  Maibach HI editor. Dry skin and moisturizers. London: CRC Press; 2000;p. 213–228
  12. Rabe JH, Mamelak AJ, McElgunn PJS, Morison WL, Sauder DN. Photoaging: mechanisms and repair. J Am Acad Dermatol. 2006;55:1–19
  13. Toyoda M, Bhawan J. Ultrastructural evidence for the participation of Langerhans cells in cutaneous photoaging process: a quantitative comparative study. J Dermatol Sci. 1997;14:87–100
  14. Grewe M. Chronological aging and photoageing of dendritic cells. Clin Exp Dermatol. 2001;26:608–612
  15. Bushan M, Cumberbatch M, Dearman RJ, Andrew SM, Kimber I, Griffiths CE. Tumor necrosis factor-alpha-induced migration of human Langerhans cells: the influence of aging. Br J Dermatol. 2002;146:32–40
  16. Pfluecker F, Buenger J, Hitzel S, et al. Complete photo protection–going beyond visible endpoints. SÖFW J. 2005;131:20–30
  17. Buenger J, Driller HJ. Ectoine: an effective natural substance to prevent UVA-induced premature photoaging. Skin Pharmacol Physiol. 2004;17:232–237
  18. Grether-Beck S, Timmer A, Felsner I, Brenden H, Brammertz D, Krutmann J. Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis. J Invest Dermatol. 2005;125:545–553
  19. Yasui H, Sakurai H. Age-dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light. Exp Dermatol. 2003;12:298–300
  20. Tolmasoff JM, Ono T, Cutler RG. Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species. Proc Natl Acad Sci U S A. 1980;77:2777–2781
  21. Loden M. The skin barrier and use of moisturizers in atopic dermatitis. Clin Dermatol. 2003;21:145–157
  22. Pape WJ, Hoppe U. Standardization of an in vitro red blood cell test for evaluating the acute cytotoxic potential of tensides. Arzneimittelforschung. 1990;40:498–502
  23. Impact, version 4.0. New York, NY: Schrödinger, LLC; 2005;
  24. Buenger J, Degwert J, Driller HJ. The protective function of compatible solute ectoine on the skin cells and its biomolecules with respect to UV-radiation, immunosuppression and membrane damage. IFSCC Mag. 2001;4:1–6
  25. VanderValk PGM, Stam-Westerveld EB, Paye M. A model to study the drying potential of detergent formulations on the skin. In:  Maibach HI editors. Dermatologic research techniques. Boca Raton (Fla): CRC Press; 1996;p. 195–205
  26. Denda M, Sato J, Tsuchiya T, Elias PM, Feingold KR. Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication of exacerbations of inflammatory dermatoses. J Invest Dermatol. 1998;111:873–878
  27. Denda M, Sato J, Masuda Y, et al. Exposure to dry environment enhances epidermal permeability barrier function. J Invest Dermatol. 1998;111:858–863
  28. Sato J, Denda M, Nakanihi J, Koyama J. Dry conditions affect desquamation of stratum corneum in vivo. J Dermatol Sci. 1998;18:163–169

PII: S0738-081X(08)00003-5

doi: 10.1016/j.clindermatol.2008.01.002

Clinics in Dermatology
Volume 26, Issue 4 , Pages 326-333 , July 2008

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