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Clinics in Dermatology
Volume 26, Issue 5
, Pages 503-508
, September 2008
Alefacept in the treatment of psoriasis
References
- . Dermal injection of immunocytes induces psoriasis. J Clin Invest. 1996;98:1878–1887
- Characterization of a T cell line bearing natural killer receptors and capable of creating psoriasis in a SCID mouse model system. J Dermatol Sci. 2000;24:212–225
- Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. J Exp Med. 2004;199:731–736
- Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation. J Immunol. 2005;174:164–173
- Cyclosporine improves psoriasis in a double-blind study. JAMA. 1986;256:3110–3116
- . Cytotoxic and immunologic effects of methotrexate in psoriasis. J Invest Dermatol. 1990;95(5 Suppl):49S–52S
- DAB486IL-2 (IL-2 toxin) selectively inactivates high-affinity IL-2 receptor–bearing human peripheral blood mononuclear cells. Ann N Y Acad Sci. 1991;636:403–405
- Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat Med. 1995;1:442–447
- T cell activation via CD2 [T, gp50] molecules: accessory cells are required to trigger T cell activation via CD2-D66 plus CD2-9.6/T11(1) epitopes. J Immunol. 1985;135:1624–1631
- Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol. 1990;144:1591–1599
- The tyrosine kinase activity of p56lck is increased in human T cells activated via CD2. Eur J Immunol. 1991;21:1967–1970
- Mechanism of lymphocyte function–associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice. J Immunol. 1994;152:2753–2767
- Short course single agent therapy with an LFA-3-IgG1 fusion protein prolongs primate cardiac allograft survival. Transplantation. 1996;61:356–363
- Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses. J Exp Med. 1993;178:211–222
- Predominance of “memory” T cells (CD4+, CDw29+) over “naive” T cells (CD4+, CD45R+) in both normal and diseased human skin. Arch Dermatol Res. 1989;281:24–30
- Proliferating cells in psoriatic dermis are comprised primarily of T cells, endothelial cells, and factor XIIIa+ perivascular dendritic cells. J Invest Dermatol. 1991;96:333–340
- Novel insight into the agonistic mechanism of alefacept in vivo: differentially expressed genes may serve as biomarkers of response in psoriasis patients. J Immunol. 2007;178:7442–7449
- A randomized, double-blind, placebo-controlled phase III study evaluating efficacy and tolerability of 2 courses of alefacept in patients with chronic plaque psoriasis. J Am Acad Dermatol. 2002;47:821–833
- . Clinical response to alefacept: results of a phase 3 study of intravenous administration of alefacept in patients with chronic plaque psoriasis. J Eur Acad Dermatol Venereol. 2003;17(Suppl 2):17–24
- Treatment of psoriasis with alefacept: correlation of clinical improvement with reductions of memory T-cell counts. Arch Dermatol. 2003;139:1563–1570
- . Improved health-related quality of life following a randomized controlled trial of alefacept treatment in patients with chronic plaque psoriasis. Br J Dermatol. 2004;150:317–326
- An international, randomized, double-blind, placebo-controlled phase 3 trial of intramuscular alefacept in patients with chronic plaque psoriasis. Arch Dermatol. 2003;139:719–727
- . Clinical response to alefacept: results of a phase 3 study of intramuscular administration of alefacept in patients with chronic plaque psoriasis. J Eur Acad Dermatol Venereol. 2003;17(Suppl 2):12–16
- . Remittive effects of intramuscular alefacept in psoriasis. J Drugs Dermatol. 2003;2:624–628
- . Intramuscular alefacept improves health-related quality of life in patients with chronic plaque psoriasis. Dermatology. 2003;206:307–315
- . Alefacept-induced decreases in circulating blood lymphocyte counts correlate with clinical response in patients with chronic plaque psoriasis. Eur J Dermatol. 2003;13:117–123
- CD4+ T-cell–directed antibody responses are maintained in patients with psoriasis receiving alefacept: results of a randomized study. J Am Acad Dermatol. 2003;49:816–825
- Repeat courses of intravenous alefacept in patients with chronic plaque psoriasis provide consistent safety and efficacy. Int J Dermatol. 2003;42:224–230
- . Amevive (Alefacept) briefing document. Dermatologic and Ophthalmic Drugs Advisory Committee Meeting. Available at: www.fda.gov/ohrms/dockets/ac/02/briefing/3865B1_01_Biogen.pdf[Internet; accessed January 26. 2005]
- . Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes. N Engl J Med. 2001;345:248–255
PII: S0738-081X(07)00251-9
doi: 10.1016/j.clindermatol.2007.10.028
© 2008 Elsevier Inc. All rights reserved.
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Clinics in Dermatology
Volume 26, Issue 5
, Pages 503-508
, September 2008
