Clinics in Dermatology
Volume 26, Issue 6 , Pages 614-626 , November 2008

The latest on skin photoprotection

  • Salvador González, MD

      Affiliations

    • Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 212 610 0185; fax: +1 212 308 0530.
  • ,
  • Manuel Fernández-Lorente, MD

      Affiliations

    • Dermatology Service, Hospital Ramón y Cajal, 28034 Madrid, Spain
  • ,
  • Yolanda Gilaberte-Calzada, MD

      Affiliations

    • Dermatology Service, Hospital General San Jorge, 22003 Huesca, Spain

References 

  1. Kullavanijaya P, Lim HW. Photoprotection. J Am Acad Dermatol. 2005;52:937–958[quiz 959-62]
  2. Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, et al. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem. 1997;378:1247–1257
  3. Leffell DJ. The scientific basis of skin cancer. J Am Acad Dermatol. 2000;42(1 Pt. 2):18–22
  4. Dummer R, Maier T. UV protection and skin cancer. Recent Results Cancer Res. 2002;160:7–12
  5. Young RW. The family of sunlight-related eye diseases. Optom Vis Sci. 1994;71:125–144
  6. Menter JM, Hatch KL. Clothing as solar radiation protection. Curr Probl Dermatol. 2003;31:50–63
  7. Cullen AP. Photokeratitis and other phototoxic effects on the cornea and conjunctiva. Int J Toxicol. 2002;21:455–464
  8. Dain SJ. Sunglasses and sunglass standards. Clin Exp Optom. 2003;86:77–90
  9. Seite S, Colige A, Piquemal-Vivenot P, et al. A full-UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging. Photodermatol Photoimmunol Photomed. 2000;16:147–155
  10. Moyal D. Immunosuppression induced by chronic ultraviolet irradiation in humans and its prevention by sunscreens. Eur J Dermatol. 1998;8:209–211
  11. van der Pols JC, Xu C, Boyle GM, et al. Expression of p53 tumor suppressor protein in sun-exposed skin and associations with sunscreen use and time spent outdoors: a community-based study. Am J Epidemiol. 2006;163:982–988
  12. Al Mahroos M, Yaar M, Phillips TJ, et al. Effect of sunscreen application on UV-induced thymine dimers. Arch Dermatol. 2002;138:1480–1485
  13. Bernerd F, Vioux C, Asselineau D. Evaluation of the protective effect of sunscreens on in vitro reconstructed human skin exposed to UVB or UVA irradiation. Photochem Photobiol. 2000;71:314–320
  14. Pattison DI, Davies MJ. Actions of ultraviolet light on cellular structures. EXS. 2006;131–157
  15. DeBuys HV, Levy SB, Murray JC, et al. Modern approaches to photoprotection. Dermatol Clin. 2000;18:577–590
  16. Stahl W, Heinrich U, Aust O, et al. Lycopene-rich products and dietary photoprotection. Photochem Photobiol Sci. 2006;5:238–242
  17. Eberlein-Konig B, Ring J. Relevance of vitamins C and E in cutaneous photoprotection. J Cosmet Derm. 2005;4:4–9
  18. Greul AK, Grundmann JU, Heinrich F, et al. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol Appl Skin Physiol. 2002;15:307–315
  19. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Orally administered Polypodium leucotomos extract decreases psoralen-UVA–induced phototoxicity, pigmentation, and damage of human skin. J Am Acad Dermatol. 2004;50:41–49
  20. Middelkamp-Hup MA, Pathak MA, Parrado C, et al. Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin. J Am Acad Dermatol. 2004;51:910–918
  21. Capote R, Alonso-Lebrero JL, Garcia F, et al. Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition. J Photochem Photobiol B. 2006;82:173–179
  22. Gonzalez S, Joshi PC, Pathak MA. Polypodium leucotomos extract as an antioxidant agent in the therapy of skin disorders. J Invest Dermatol. 1994;102:651–659
  23. Gonzalez S, Pathak MA, Cuevas J, et al. Topical or oral administration with an extract of Polypodium leucotomos prevents acute sunburn and psolaren-induced phototoxic reactions as well as depletion of Langerhans cells in human skin. Photodermatol Photoimmunol Photomed. 1997;13:50–60
  24. Alonso-Lebrero JL, Domínguez-Jiménez C, Tejedor R, et al. Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. J Photochem Photobiol B. 2003;70:31–37
  25. Katiyar S, Elmets CA, Katiyar SK. Green tea and skin cancer: photoimmunology, angiogenesis and DNA repair. J Nutr Biochem. 2007;18(5):287–296
  26. Vayalil PK, Mittal A, Hara Y, et al. Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol. 2004;122:1480–1487
  27. Wei H, Saladi R, Lu Y, et al. Isoflavone genistein: photoprotection and clinical implications in dermatology. J Nutr. 2003;133(11 Suppl 1):3811S–3819S
  28. Rhodes LE, O'Farrell S, Jackson MJ, et al. Dietary fish-oil supplementation in humans reduces UVB-erythemal sensitivity but increases epidermal lipid peroxidation. J Invest Dermatol. 1994;103:151–154
  29. Kligman LH. Prevention and repair of photoaging: sunscreens and retinoids. Cutis. 1989;43:458–465
  30. Thompson SC, Jolley D, Marks R. Reduction of solar keratoses by regular sunscreen use. N Engl J Med. 1993;329:1147–1151
  31. Neale R, Williams G, Green A. Application patterns among participants randomized to daily sunscreen use in a skin cancer prevention trial. Arch Dermatol. 2002;138:1319–1325
  32. Green A, Williams G, Neale R, et al. Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet. 1999;354:723–729
  33. Boyd AS, Naylor M, Cameron GS, et al. The effects of chronic sunscreen use on the histologic changes of dermatoheliosis. J Am Acad Dermatol. 1995;33:941–946
  34. Sano T, Kume T, Fujimura T, et al. The formation of wrinkles caused by transition of keratin intermediate filaments after repetitive UVB exposure. Arch Dermatol Res. 2005;296:359–365
  35. Krutmann J. Ultraviolet A radiation-induced biological effects in human skin: relevance for photoaging and photodermatosis. J Dermatol Sci. 2000;23(Suppl 1):S22–S26
  36. Lowe NJ. An overview of ultraviolet radiation, sunscreens, and photo-induced dermatoses. Dermatol Clin. 2006;24:9–17
  37. Perugini P, Simeoni S, Scalia S, et al. Effect of nanoparticle encapsulation on the photostability of the sunscreen agent, 2-ethylhexyl-p-methoxycinnamate. Int J Pharm. 2002;246:37–45
  38. de Freitas ZM, dos Santos EP, da Rocha JF, et al. A new sunscreen of the cinnamate class: synthesis and enzymatic hydrolysis evaluation of glyceryl esters of p-methoxycinnamic acid. Eur J Pharm Sci. 2005;25:67–72
  39. Seite S, Moyal D, Richard S, et al. Mexoryl SX: a broad absorption UVA filter protects human skin from the effects of repeated suberythemal doses of UVA. J Photochem Photobiol B. 1998;44:69–76
  40. Moyal D. Prevention of ultraviolet-induced skin pigmentation. Photodermatol Photoimmunol Photomed. 2004;20:243–247
  41. Chatelain E, Gabard B. Photostabilization of butyl methoxydibenzoylmethane (Avobenzone) and ethylhexyl methoxycinnamate by bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. Photochem Photobiol. 2001;74:401–406
  42. Lapidot N, Gans O, Biagini F, et al. Advanced sunscreens: UV absorbers encapsulated in sol-gel glass microcapsules. J Sol-Gel Sci Technol. 2003;26:67–72
  43. Pinnell SR, Fairhurst D, Gillies R, et al. Microfine zinc oxide is a superior sunscreen ingredient to microfine titanium dioxide. Dermatol Surg. 2000;26:309–314
  44. Wamer WG, Yin JJ, Wei RR. Oxidative damage to nucleic acids photosensitized by titanium dioxide. Free Radic Biol Med. 1997;23:851–858
  45. Van Reeth I. Beyond skin feel: innovative methods for developing complex sensory profiles with silicones. J Cosmet Derm. 2006;5:61–67
  46. Villalobos-Hernandez JR, Muller-Goymann CC. Novel nanoparticulate carrier system based on carnauba wax and decyl oleate for the dispersion of inorganic sunscreens in aqueous media. Eur J Pharm Biopharm. 2005;60:113–122
  47. Villalobos-Hernandez JR, Muller-Goymann CC. Sun protection enhancement of titanium dioxide crystals by the use of carnauba wax nanoparticles: the synergistic interaction between organic and inorganic sunscreens at nanoscale. Int J Pharm. 2006;322:161–170
  48. Villalobos-Hernandez JR, Muller-Goymann CC. In vitro erythemal UV-A protection factors of inorganic sunscreens distributed in aqueous media using carnauba wax-decyl oleate nanoparticles. Eur J Pharm Biopharm. 2007;65:122–125
  49. Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol. 2003;48:1–19[quiz 20-12]
  50. Goto S, Kogure K, Abe K, et al. Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin. Biochim Biophys Acta. 2001;1512:251–258
  51. Lambert JD, Hong J, Yang GY, et al. Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations. Am J Clin Nutr. 2005;81(1 Suppl):284S–291S
  52. Rutter K, Sell DR, Fraser N, et al. Green tea extract suppresses the age-related increase in collagen crosslinking and fluorescent products in C57BL/6 mice. Int J Vitam Nutr Res. 2003;73:453–460
  53. Hsu S. Green tea and the skin. J Am Acad Dermatol. 2005;52:1049–1059
  54. Dvorakova K, Dorr RT, Valcic S, et al. Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin. Cancer Chemother Pharmacol. 1999;43:331–335
  55. Afaq F, Adhami VM, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol. 2003;186:28–37
  56. Aziz MH, Reagan-Shaw S, Wu J, et al. Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease?. FASEB J. 2005;19:1193–1195
  57. Shyong EQ, Lu Y, Lazinsky A, et al. Effects of the isoflavone 4′,5,7-trihydroxyisoflavone (genistein) on psoralen plus ultraviolet A radiation (PUVA)-induced photodamage. Carcinogenesis. 2002;23:317–321
  58. Katiyar SK. Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects. (Review) Int J Oncol. 2005;26:169–176
  59. Widyarini S, Husband AJ, Reeve VE. Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen. Photochem Photobiol. 2005;81:32–37
  60. Reeve VE, Widyarini S, Domanski D, et al. Protection against photoaging in the hairless mouse by the isoflavone equol. Photochem Photobiol. 2005;81:1548–1553
  61. Widyarini S, Allanson M, Gallagher NL, et al. Isoflavonoid photoprotection in mouse and human skin is dependent on metallothionein. J Invest Dermatol. 2006;126:198–204
  62. Casagrande R, Georgetti SR, Verri WA, et al. Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice. J Photochem Photobiol B. 2006;84:21–27
  63. Tong X, Van Dross RT, Abu-Yousif A, et al. Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition. Mol Cell Biol. 2007;27:283–296
  64. Saija A, Tomaino A, Trombetta D, et al. In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents. Int J Pharm. 2000;199:39–47
  65. Afaq F, Mukhtar H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp Dermatol. 2006;15:678–684
  66. Sime S, Reeve VE. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol. Photochem Photobiol. 2004;79:193–198
  67. Brieva A, Guerrero A, Pivel JP. Immunomodulatory properties of an hydrophilic extract of Polypodium leucotomos. Inflammopharmacol. 2002;9:361–371
  68. Alcaraz MV, Pathak MA, Rius F, et al. An extract of Polypodium leucotomos appears to minimize certain photoaging changes in a hairless albino mouse animal model. Photodermatol Photoimmunol Photomed. 1999;15:120–126
  69. Hamanaka H, Miyachi Y, Imamura S. Photoprotective effect of topically applied superoxide dismutase on sunburn reaction in comparison with sunscreen. J Dermatol. 1990;17:595–598
  70. Damiani E, Astolfi P, Cionna L, et al. Synthesis and application of a novel sunscreen-antioxidant. Free Radic Res. 2006;40:485–494
  71. Draelos ZD. Self-tanning lotions: are they a healthy way to achieve a tan?. Am J Clin Dermatol. 2002;3:317–318
  72. Stege H, Roza L, Vink AA, et al. Enzyme plus light therapy to repair DNA damage in ultraviolet-B–irradiated human skin. Proc Natl Acad Sci U S A. 2000;97:1790–1795
  73. Yarosh D, Klein J, O'Connor A, et al. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet. 2001;357:926–929
  74. Goukassian DA, Helms E, van Steeg H, et al. Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. Proc Natl Acad Sci U S A. 2004;101:3933–3938
  75. Arad S, Konnikov N, Goukassian DA, et al. T-oligos augment UV-induced protective responses in human skin. FASEB J. 2006;20:1895–1897
  76. Lu YP, Lou YR, Xie JG, et al. Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice. Carcinogenesis. 2007;28:199–206
  77. Hwang IK, Yoo KY, Kim DW, et al. An extract of Polygonum multiflorum protects against free radical damage induced by ultraviolet B irradiation of the skin. Braz J Med Biol Res. 2006;39:1181–1188
  78. Kitazawa M, Ishitsuka Y, Kobayashi , et al. Protective effects of an antioxidant derived from serine and vitamin B6 on skin photoaging in hairless mice. Photochem Photobiol. 2005;81:970–974
  79. Machowinski A, Kramer HJ, Hort W, et al. Pityriacitrin—a potent UV filter produced by Malassezia furfur and its effect on human skin microflora. Mycoses. 2006;49:388–392
  80. Lenz H, Schmidt M, Welge V, et al. The creatine kinase system in human skin: protective effects of creatine against oxidative and UV damage in vitro and in vivo. J Invest Dermatol. 2005;124:443–452
  81. Fischer SM, Lo HH, Gordon GB, et al. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol Carcinog. 1999;25:231–240
  82. Wilgus TA, Koki AT, Zweifel BS, et al. Inhibition of cutaneous ultraviolet light B-mediated inflammation and tumor formation with topical celecoxib treatment. Mol Carcinog. 2003;38:49–58
  83. Hanneman KK, Cooper KD, Baron ED. Ultraviolet immunosuppression: mechanisms and consequences. Dermatol Clin. 2006;24:19–25
  84. Lavker RM, Gerberick GF, Veres D, et al. Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. J Am Acad Dermatol. 1995;32:53–62
  85. Tsukahara K, Moriwaki S, Hotta M, et al. The effect of sunscreen on skin elastase activity induced by ultraviolet-A irradiation. Biol Pharm Bull. 2005;28:2302–2307
  86. Nash JF, Tanner PR, Matts PJ. Ultraviolet A radiation: testing and labeling for sunscreen products. Dermatol Clin. 2006;24:63–74
  87. Maier T, Korting HC. Sunscreens—which and what for?. Skin Pharmacol Physiol. 2005;18:253–262
  88. Berneburg M, Grether-Beck S, Kurten V, et al. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem. 1999;274:15345–15349
  89. ICNIRP statement on far infrared radiation exposure. Health Phys. 2006;91:630–645
  90. Kim HH, Lee MJ, Lee SR, et al. Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mech Ageing Dev. 2005;126:1170–1177
  91. Kim MS, Kim YK, Cho KH, et al. Regulation of type I procollagen and MMP-1 expression after single or repeated exposure to infrared radiation in human skin. Mech Ageing Dev. 2006;127:875–882
  92. Fourtanier A, Moyal D, Maccario J, et al. Measurement of sunscreen immune protection factors in humans: a consensus paper. J Invest Dermatol. 2005;125:403–409
  93. Foley P, Nixon R, Marks R, et al. The frequency of reactions to sunscreens: results of a longitudinal population-based study on the regular use of sunscreens in Australia. Br J Dermatol. 1993;128:512–518
  94. Bryden AM, Moseley H, Ibbotson SH, et al. Photopatch testing of 1155 patients: results of the U.K. multicentre photopatch study group. Br J Dermatol. 2006;155:737–747
  95. Darvay A, White IR, Rycroft RJ, et al. Photoallergic contact dermatitis is uncommon. Br J Dermatol. 2001;145:597–601
  96. Marrot L, Belaidi JP, Lejeune F, et al. Photostability of sunscreen products influences the efficiency of protection with regard to UV-induced genotoxic or photoageing-related endpoints. Br J Dermatol. 2004;151:1234–1244
  97. Gaspar LR, Maia P, Campos M. Evaluation of the photostability of different UV filter combinations in a sunscreen. Int J Pharm. 2006;307:123–128
  98. Nash JF. Human safety and efficacy of ultraviolet filters and sunscreen products. Dermatol Clin. 2006;24:35–51
  99. Nakagawa Y, Wakuri S, Sakamoto K, et al. The photogenotoxicity of titanium dioxide particles. Mutat Res. 1997;394:125–132
  100. Hayden CG, Cross SE, Anderson C, et al. Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Skin Pharmacol Physiol. 2005;18:170–174
  101. Holick MF. Vitamin D: a millenium perspective. J Cell Biochem. 2003;88:296–307
  102. Wolpowitz D, Gilchrest BA. The vitamin D questions: how much do you need and how should you get it?. J Am Acad Dermatol. 2006;54:301–317
  103. Garland CF, Garland FC, Gorham ED. Calcium and vitamin D. Their potential roles in colon and breast cancer prevention. Ann N Y Acad Sci. 1999;889:107–119
  104. Garland CF. More on preventing skin cancer: sun avoidance will increase incidence of cancers overall. BMJ. 2003;327:1228
  105. Hughes AM, Armstrong BK, Vajdic CM, et al. Sun exposure may protect against non-Hodgkin lymphoma: a case-control study. Int J Cancer. 2004;112:865–871
  106. Grant WB, Garland CF. Evidence supporting the role of vitamin D in reducing the risk of cancer. J Intern Med. 2002;252:178–179[author reply 179-80]
  107. De Haes P, Garmyn M, Degreef H, et al. 1,25-Dihydroxyvitamin D3 inhibits ultraviolet B-induced apoptosis, Jun kinase activation, and interleukin-6 production in primary human keratinocytes. J Cell Biochem. 2003;89:663–673
  108. De Haes P, Garmyn M, Verstuyf A, et al. Two 14-epi analogues of 1,25-dihydroxyvitamin D3 protect human keratinocytes against the effects of UVB. Arch Dermatol Res. 2004;295:527–534
  109. De Haes P, Garmyn M, Carmeliet G, et al. Molecular pathways involved in the anti-apoptotic effect of 1,25-dihydroxyvitamin D3 in primary human keratinocytes. J Cell Biochem. 2004;93:951–967
  110. Tremezaygues L, Sticherling M, Pfohler C, et al. Cutaneous photosynthesis of vitamin D: an evolutionary highly-conserved endocrine system that protects against environmental hazards including UV-radiation and microbial infections. Anticancer Res. 2006;26:2743–2748
  111. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80(6 Suppl):1678S–1688S
  112. Nowson CA, Diamond TH, Pasco JA, et al. Vitamin D in Australia. Issues and recommendations. Aust Fam Physician. 2004;33:133–138
  113. Gustavsson Gonzalez H, Farbrot A, Larko O. Percutaneous absorption of benzophenone-3, a common component of topical sunscreens. Clin Exp Dermatol. 2002;27:691–694
  114. Gamer AO, Leibold E, van Ravenzwaay B. The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol In Vitro. 2006;20:301–307
  115. Borm PJ, Robbins D, Haubold S, et al. The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol. 2006;3:11
  116. Schulz J, Hohenberg H, Pflucker F, et al. Distribution of sunscreens on skin. Adv Drug Deliv Rev. 2002;54(Suppl 1):S157–S163
  117. Kunz PY, Fent K. Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish. Aquat Toxicol. 2006;79:305–324
  118. Schlumpf M, Cotton B, Conscience M, et al. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect. 2001;109:239–244
  119. Heneweer M, Muusse M, van den Berg M, et al. Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells. Toxicol Appl Pharmacol. 2005;208:170–177
  120. McHugh PJ, Knowland J. Characterization of DNA damage inflicted by free radicals from a mutagenic sunscreen ingredient and its location using an in vitro genetic reversion assay. Photochem Photobiol. 1997;66:276–281
  121. Dunford R, Salinaro A, Cai L, et al. Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients. FEBS Lett. 1997;418:87–90
  122. Hanson KM, Gratton E, Bardeen CJ. Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med. 2006;41:1205–1212
  123. Wang SQ, Setlow R, Berwick M, et al. Ultraviolet A and melanoma: a review. J Am Acad Dermatol. 2001;44:837–846
  124. Gallagher RP. Sunscreens in melanoma and skin cancer prevention. CMAJ. 2005;173:244–245
  125. Vainio H, Miller AB, Bianchini F. An international evaluation of the cancer-preventive potential of sunscreens. Int J Cancer. 2000;88:838–842
  126. Huncharek M, Kupelnick B. Use of topical sunscreen and the risk of malignant melanoma. Results of a meta-analysis of 9,067 patients. Ann Epidemiol. 2000;10:467
  127. Gallagher RP, Rivers JK, Lee TK, et al. Broad-spectrum sunscreen use and the development of new nevi in white children: a randomized controlled trial. JAMA. 2000;283:2955–2960
  128. Kunz PY, Galicia HF, Fent K. Comparison of in vitro and in vivo estrogenic activity of UV filters in fish. Toxicol Sci. 2006;90:349–361
  129. Saraiya M, Glanz K, Briss PA, et al. Interventions to prevent skin cancer by reducing exposure to ultraviolet radiation: a systematic review. Am J Prev Med. 2004;27:422–466
  130. Enta T, Kwan TY. Melanocytic nevi in sun-protected Canadian Hutterite children. Arch Dermatol. 1998;134:379–381
  131. Rossi JS, Blais LM, Redding CA, et al. Preventing skin cancer through behavior change. Implications for interventions. Dermatol Clin. 1995;13:613–622
  132. Saraiya M, Glanz K, Briss P, et al. Preventing skin cancer: findings of the Task Force on Community Preventive Services on reducing Exposure to Ultraviolet Light. MMWR Recomm Rep. 2003;52:1–12
  133. Mahler HI, Kulik JA, Harrell J, et al. Effects of UV photographs, photoaging information, and use of sunless tanning lotion on sun protection behaviors. Arch Dermatol. 2005;141:373–380
  134. Sinclair C. Risks and benefits of sun exposure: implications for public health practice based on the Australian experience. Prog Biophys Mol Biol. 2006;92:173–178
  135. Eide MJ, Weinstock MA. Public health challenges in sun protection. Dermatol Clin. 2006;24:119–124
  136. Twombly R. New carcinogen list includes estrogen, UV radiation. J Natl Cancer Inst. 2003;95:185–186

PII: S0738-081X(07)00194-0

doi: 10.1016/j.clindermatol.2007.09.010

Clinics in Dermatology
Volume 26, Issue 6 , Pages 614-626 , November 2008