Clinics in Dermatology
Volume 26, Issue 6 , Pages 641-647 , November 2008

Aging skin and food supplements: the myth and the truth

  • Claudia Rona, MD

      Affiliations

    • Department of Dermatology, University of Pavia, 27100 Pavia, Italy
  • ,
  • Enzo Berardesca, MD

      Affiliations

    • San Gallicano Dermatological Institute, 0144 Rome, Italy
    • Corresponding Author InformationCorresponding author.

References 

  1. Purba MB, Kouris-Blazos A, Wattanapenpaiboon N, et al. Skin wrinkling: can food make a difference?. J Am Coll Nutr. 2001;20:71–80
  2. Tebbe B. Relevance of oral supplementation with antioxidants for prevention and treatment of skin disorders. Skin Pharmacol Appl Skin Physiol. 2001;14:296–302
  3. Lee J, Jiang S, Levine N, et al. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. Proc Soc Exp Biol Med. 2000;223:170–174
  4. McArdle F, Rhodes LE, Parslew RA, et al. Effects of oral vitamin E and beta-carotene supplementation on ultraviolet radiation–induced oxidative stress in human skin. Am J Clin Nutr. 2004;80:1270–1275
  5. McArdle F, Rhodes LE, Parslew R, et al. UVR-induced oxidative stress in human skin in vivo: effects of oral vitamin C supplementation. Free Radic Biol Med. 2002;33:1355–1362
  6. Podda M, Grundmann-Kollmann M. Low molecular weight antioxidants and their role in skin ageing. Clin Exp Dermatol. 2001;26:578–582
  7. Shoji Y, Nakashima H. Nutraceutics and delivery systems. J Drug Target. 2004;12:385–391
  8. Chiu AE, Chan JL, Kern DG, et al. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg. 2005;31:855–860
  9. Sthal W, Heinrich U, Aust O, et al. Lycopene-rich products and dietary photoprotection. Photochem Photobiol Sci. 2006;5:238–242
  10. Sthal W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta. 2005;1740:101–107
  11. Sies H, Sthal W. Carotenoids and UV protection. Photochem Photobiol Sci. 2004;3:749–752
  12. Sies H, Sthal W. Nutritional protection against skin damage from sunlight. Annu Rev Nutr. 2004;24:173–200
  13. Thom E. A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin. J Int Med Res. 2005;33:267–272
  14. Cossins E, Lee R, Pacher L. Pycnogenol prolongs the lifetime of vitamin C more than other flavonoids. Biochem Mol Biol Int. 1998;45:583–597
  15. Schonlau F. The cosmeceutical Pycnogenol. J Appl Cosm. 2002;20:38
  16. Tixier JM, Godeau G, Robert AM, et al. Evidence by in vitro e in vivo studies that binding of Pycnogenols to elastin affects its rate of degradation by elastases. Biochem Pharmacol. 1984;33:3933–3939
  17. Saliou C, Rimbach G, Moini H, et al. Solar ultraviolet induced erythema in human skin and nuclear factor-kappa-B–dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Rad Biol Med. 2001;30:154–160
  18. Rohdewald P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with diverse clinical pharmacology. Int J Clin Pharmacol Ther. 2002;40:158–168
  19. Blazso G, Gabor M, Rohdewald P. Pycnogenol produces an antioedema effect. Topical application of Pycnogenol gel protects he skin against UV radiation. Pharmazie. 1997;52:380–382
  20. Blazso G, Rohdewald P, Sibbel R, et al. Pycnogenol produces an antioedema effect. Applied topically Pycnogenol significantly reduces UVB radiation induced erythema. In:  Antus S,  Gabor M,  Vetschera K editor. Proceedings of International Bioflavonoids Symposium, Vienna, Austria, July 16-19. 1995;p. 231–238
  21. Segger D, Schonlau F. Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women. J Dermatolog Treat. 2004;15:222–226
  22. Murad H, Tabibian MP. The effect of an oral supplement containing glucosamine, amino acids, minerals, and antioxidants on cutaneous aging: a preliminary study. J Dermatolog Treat. 2001;12:47–51
  23. Morganti P, Bruno C, Guarneri F, et al. Role of nutritional supplement to modify the oxidative stress. J Appl Cosm. 2002;20:108
  24. Sthal W, Heinrich U, Jungmann H, et al. Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans. Am J Clin Nutr. 2000;71:795–798
  25. Morganti P, Fabrizi G, Bruno C. Protective effects of oral antioxidants on skin and eye function. Skinmed. 2004;3:310–316
  26. Krieger E. Lutein: natural bioactive antioxidant for eye and skin health.. J Appl Cosm. 2002;20:14
  27. Alves-Rodrigues A. Lutein: an update of its benefits in human health. J Appl Cosm. 2002;20:13
  28. Richelle M, Bortlik K, Liardet S, et al. A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. J Nutr. 2002;132:404–408
  29. Vertuani S, Manfredini S. Fito-tocotrienoli: la vitamina E del terzo millennio. Cosm Technol. 2001;4:21–23
  30. Suzuki YJ, Tsuchiya M, Wassal SR, et al. Structural and dynamic membrane properties of alpha tocopherol and alpha tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry. 1993;32:10692
  31. McIntyre BS, Briski KP, Tirmenstein MA, et al. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary e epithelial cells. Lipids. 2000;35:171
  32. Ikeda S, Niwa T, Yamashita K. Selective uptake of dietary tocotrienols into rat skin. Nutr Sci Vitaminol. 2000;46:141
  33. Weber C, Podda M, Rallis M, et al. Efficacy of topically applied tocopherols and tocotrienols in protection on murine skin from oxidative damage induced by UV-irradiation. Free Radic Biol Med. 1997;22:761
  34. Eskelinin A, Santalahti J. Special natural cartilage polysaccharides for the treatment of the sun damaged skin in females. J Int Med Res. 1992;20:99
  35. Distante F, Scalise F, Rona C, et al. Oral fish cartilage polysaccharides in the treatment of photoageing: biophysical findings. Int J Cosm Sci. 2002;24:1–7
  36. Primavera G, Berardesca E. Clinical and instrumental evaluation of a food supplement in improving skin hydration. Int J Cosm Sci. 2005;27:199–204

PII: S0738-081X(07)00186-1

doi: 10.1016/j.clindermatol.2007.09.002

Clinics in Dermatology
Volume 26, Issue 6 , Pages 641-647 , November 2008