Clinics in Dermatology
Volume 25, Issue 6 , Pages 563-567 , November 2007

The genetic basis of psoriasis

References 

  1. Iafrate AJ, Feuk L, Rivera MN, et al. Detection of a large scale variation in the human genome. Nat Genet. 2004;36:949–951
  2. Kruglyak L, Nickerson DA. Variation is the spice of life. Nat Genet. 2001;27:234–236
  3. Hirschhorn JN. Genetic approaches to studying common diseases and complex traits. Pediatr Res. 2005;57:74R–77R
  4. Dean M. Approaches to identify genes for complex human diseases: lessons from Mendelian disorders. Hum Mutat. 2003;22:261–274
  5. Fijneman RJ, de Vries SS, Jansen RC, et al. Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3 and Sluc4 that influence the susceptibility to lung cancer in the mouse. Nat Genet. 1996;14:465–467
  6. Rivolta C, Sharon D, DeAngelis MM, et al. Retinitis pigmentosa and allied diseases: numerous diseases, genes and inheritance patterns. Hum Mol Genet. 2002;11:1219–1227
  7. Lohmuller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseases. Nat Genet. 2003;33:177–182
  8. Altmüller J, Palmer LJ, Fischer G, Scherb H, Wjist M. Genome wide linkage scans of complex human diseases: true linkage is hard to find. Am J Hum Genet. 2001;69:936–950
  9. Walsh EC, Mather KA, Schaffner SF, et al. An integrated haplotype map of the human major histocompatibility complex. Am J Hum Genet. 2003;73:580–590
  10. Nair RN, Stuart PE, Nistor I, et al. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 2006;78:827–851
  11. Nair RP, Stuart PE, Henseler T, et al. Localization of psoriasis susceptibility locus 1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet. 2000;66:1833–1844
  12. Gudjonsson JE, Johnston A, Sigmundsdottir H, Valdimarsson H. Immunopathogenic mechanisms in psoriasis. Clin Exp Immunol. 2004;135:1–8
  13. Menssen A, Trommler P, Vollmer S, et al. Evidence for an antigen specific response in skin lesions of patients with psoriasis vulgaris. J Immunol. 1995;155:4078–4083
  14. Chang JCC, Smith LR, Froning KJ, et al. Persistence of T cell clones in psoriasis lesions. Arch Dermatol. 1997;133:703–708
  15. Bour H, Puisieux I, Even J, et al. T cell repertoire analysis in chronic plaque psoriasis suggests an antigen specific immune response. Hum Immunol. 1999;60:665–676
  16. Diluvio L, Vollmer S, Begsen P, et al. Identical TCR β-chain rearrangements in streptococcal angina and skin lesions of patients with psoriasis vulgaris. J Immunol. 2006;176:7104–7111
  17. Johnston A, Gudjonsson JE, Sigmundsdottir H, et al. Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M-protein are largely restricted to skin-homing CD8+ T cells. Clin Exp Immunol. 2004;138:83–93
  18. Sagoo GS, Cork MJ, Patel R, et al. Genome-wide studies of psoriasis susceptibility loci: a review. J Dermatol Sci. 2004;35:171–179
  19. Jullien D, Barker JN. Genetics of psoriasis. J Eur Acad Dermatol Venereol. 2006;20(suppl):42–51
  20. Tomfohrde J, Silverman A, Barnes R, et al. Gene for familial psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science. 1994;264:1141–1145
  21. Samuelsson L, Enlund F, Torinson A, et al. A genome-wide search for genes predisposing to familial psoriasis by using stratification approach. Hum Genet. 1999;105:523–529
  22. Nair RP, Henseler T, Jenisch S, et al. Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by a genome-wide scan. Hum Mol Genet. 1997;6:1349–1356
  23. Helms C, Cao L, Krueger JG, et al. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet. 2003;35:349–356
  24. Stuart P, Nair PR, Abecasis GR, et al. Analysis of RUNX1 binding site and RAPTOR polymorphism in psoriasis: no evidence for association despite adequate power and evidence for linkage. J Med Genet. 2006;43:12–17
  25. Matthews D, Fry L, Powles A, et al. Evidence for a locus for familial psoriasis maps to chromosome 4q. Nat Genet. 1996;14:231–233
  26. Foerster J, Nolte I, Schweiger S, et al. Evaluation of the IRF-2 gene as a candidate for PSORS3. J Invest Dermatol. 2004;122:61–64
  27. Hida S, Ogasawara K, Sato K, et al. CD8+ T cell mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling. Immunity. 2000;13:643–655
  28. Zhang XJ, He PP, Wang ZX, et al. Evidence for a major psoriasis susceptibility locus at 6p21 (PSORS1) and a novel candidate region at 4q31 by genome-wide scan in Chinese hans. J Invest Dermatol. 2002;119:1361–1366
  29. Sagoo GS, Tazi-Ahnini R, Barker JW, et al. Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-31. J Invest Dermatol. 2004;122:1401–1405
  30. Karason A, Gudjonsson JE, Jonsson HH, et al. Genetics of psoriasis in Iceland: evidence for linkage of subphenotypes to distinct loci. J Invest Dermatol. 2005;124:1177–1185
  31. Willasden LS, Schurman J, Beurskens F, et al. Resolution of psoriasis upon blockage of Il-15 biologic activity in a xenograft mouse model. J Clin Invest. 2003;112:1571–1580
  32. Bhalerao JU, Bowcock AM. The genetics of psoriasis: a complex disorder of the skin and immune system. Hum Mol Genet. 1998;7:1537–1545
  33. Capon F, Novelli G, Semprini S, et al. Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1. J Invest Dermatol. 1999;112:32–35
  34. Semprini S, Capon F, Tacconelli A, et al. Evidence for S100 gene over-expression in psoriatic patients from genetically heterogeneous pedigrees. Hum Genet. 2002;111:310–313
  35. Lee YA, Rüschendorf F, Windemuth C, et al. Genome-wide scan in German families reveals evidence for a novel psoriasis-susceptibility locus on chromosome 19p13. Am J Hum Genet. 2000;67:1020–1024
  36. Zenz R, Eferl R, Kenner L, et al. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature. 2005;437:369–375
  37. Farber EM, Nall L. The natural history of psoriasis in 5600 patients. Dermatologica. 1974;148:1–18
  38. Brandrup F, Holm N, Grunnet N, et al. Psoriasis in monozygotic twins: variations in expression in individuals with identical genetic constitution. Acta Derm Venerol. 1982;62:229–236
  39. Gudjonsson JE, Karason A, Runarsdottir EH, et al. Distinct clinical differences between HLA-C*w6 positive and negative psoriasis patients: an analysis of 1019 HLA-C and HLA-B typed patients. J Invest Dermatol. 2006;126:740–745

PII: S0738-081X(07)00154-X

doi: 10.1016/j.clindermatol.2007.08.010

Clinics in Dermatology
Volume 25, Issue 6 , Pages 563-567 , November 2007

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