Clinics in Dermatology
Volume 25, Issue 6 , Pages 535-546, November 2007

Psoriasis: epidemiology

  • Johann E. Gudjonsson, MD

      Affiliations

    • Department of Dermatology, University of Michigan School of Medicine, Box 0932, Ann Arbor, MI 48109-0932, USA
    • Department of Radiation Oncology, University of Michigan School of Medicine, Box 0932, Ann Arbor, MI 48109-0932, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 734 763 0355; fax: +1 734 763 4575.
    • ,
  • James T. Elder, MD

      Affiliations

    • Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI USA

Abstract 

Psoriasis is a chronic, inflammatory and hyperproliferative skin disease with a genetic basis. While epidermal hyperplasia and altered keratinocyte differentiation are prominent features, considerable evidence indicates that psoriasis is immunologically mediated. Recently, the identification of HLA-Cw6 as the disease allele conferring susceptibility to psoriasis has provided a focus for elucidation of these events. In this article, we will focus on the epidemiology of psoriasis and its associated arthritis.

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PII: S0738-081X(07)00151-4

doi:10.1016/j.clindermatol.2007.08.007

Clinics in Dermatology
Volume 25, Issue 6 , Pages 535-546, November 2007

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