Clinics in Dermatology
Volume 25, Issue 3 , Pages 326-333 , May 2007

Sarcoidosis and malignancy

  • Philip R. Cohen, MD

      Affiliations

    • University of Houston Health Center, Houston, TX 77204, USA and Department of Dermatology, University of Texas-Houston Medical School, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. 805 Anderson Street, Bellaire, TX 77401-2806, USA.
  • ,
  • Razelle Kurzrock, MD

      Affiliations

    • Phase I Program, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA

References 

  1. Cather JC, Cohen PR. Ichthyosiform sarcoidosis. J Am Acad Dermatol. 1999;40:862–865
  2. Cather H, Bahram S, Khachemoune A. Dermatologic diseases. In:  Baughman R editors. Sarcoidosis. New York: Taylor & Francis; 2006;p. 593–604
  3. Khachemoune A, Rodriguez C. Sarcoidosis in aging skin. In: Norman R, editor. Differential diagnosis of aging skin diseases. Spriger-Verlag [in press].
  4. Zax RH, Callen JP. Sarcoidosis. Dermatol Clin. 1989;7:505–515
  5. Samtsov AV. Cutaneous sarcoidosis. Int J Dermatol. 1992;31:385–391
  6. Mana J, Marcoval J, Graells J, Salazar A, Peyri J, Pujol R. Cutaneous involvement in sarcoidosis: relationship to systemic disease. Arch Dermatol. 1997;133:882–888
  7. Tjan-Heijnen VCG, Vlasveld LTh, Pernet FPPM, Pauwels P, DeMulder PHM. Coincidence of seminoma and sarcoidosis: a myth or fact?. Ann Oncol. 1998;9:321–325
  8. Cohen PR, Kurzrock R. Mucocutaneous paraneoplastic syndromes. Semin Oncol. 1997;24:334–359
  9. Kurzrock R, Cohen PR. Mucocutaneous paraneoplastic manifestations of hematologic malignancies. Am J Med. 1995;99:207–216
  10. Kurzrock R, Cohen PR. Cutaneous paraneoplastic syndromes in solid tumors. Am J Med. 1995;99:662–671
  11. Cohen PR. Cutaneous paraneoplastic syndromes. Am Fam Physician. 1994;50:1273–1282
  12. Cohen PR. Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy-associated mucocutaneous paraneoplastic syndromes. Int J Dermatol. 2006;45:70–80
  13. Herxheimer G. Uber karzinoma und tuberkulose. Z Tuberk. 1917;27:251–258
  14. Kurata A, Terado Y, Schulz A, Fujioka Y, Franke FE. Inflammatory cells in the formation of tumor-related sarcoid reactions. Hum Pathol. 2005;36:546–554
  15. Pandha HS, Griffiths H, Waxman J. Sarcoidosis and cancer. [editorial] Clin Oncol. 1995;7:277–278
  16. Kornacker M, Kraemer A, Leo E, Ho AD. Occurrence of sarcoidosis subsequent to chemotherapy for non-Hodgkin's lymphoma: report of two cases. Ann Hematol. 2002;81:103–105
  17. Wolbach SB. A new type of cell inclusion, not parasitic, associated with disseminated granulomatous lesions. J Med Res. 1911;24:243–258
  18. Pujol RM, Matias-Guiu X, Planaguma M, de Moragas JM. Chronic lymphocytic leukemia and cutaneous granulomas at sites of herpes zoster scars. Int J Dermatol. 1990;29:652–654
  19. Bachmeyer C, Debs R, Aractingi S. Cutaneous sarcoidlike lesions in B-cell chronic lymphocytic leukemia. J Am Acad Dermatol. 2003;49:S180–S181
  20. Yavorkovsky LL, Carrum G, Bruce S, McCarthy PL. Cutaneous sarcoidosis in a patient with Philadelphia-positive chronic myelogenous leukemia treated with interferon-alpha. Am J Hematol. 1998;58:80–81
  21. Sacks EL, Donaldson SS, Gordon J, Dorfman RF. Epithelioid granulomas associated with Hodgkin's disease. Clinical correlation in 55 previously untreated patients. Cancer. 1978;41:562–567
  22. Berg van den JWK, Fickers M, Theunissen P, van Noord JA. Pulmonary sarcoid-like granulomata in a patient treated for extrapulmonary Hodgkin's disease. Respiration. 1997;64:114–117
  23. Brincker H. Sarcoid reactions and sarcoidosis in Hodgkin's disease and other malignant lymphomata. Br J Cancer. 1972;26:120–128
  24. de Hemricourt E, de Boeck K, Hilte F, et al. Sarcoidosis and sarcoid-like reaction following Hodgkin's disease: report of two cases. Mol Imaging Biol. 2003;5:15–19
  25. Brincker H. Sarcoid reactions in malignant tumours. Cancer Treat Rev. 1986;13:147–156
  26. Anderson R, Geraint-James D, Peters PM, Thomson AD. Local sarcoid-tissue reaction. Lancet. 1962;1:1211–1213
  27. Whittaker JA, Slater A, Al-Ismail SA, et al. An assessment of laparotomy in the management of patients with Hodgkin's disease. Q J Med. 1978;47:291–301
  28. Sawhney M, Sharma YK, Gera V, Jetley S. Ichthyosiform sarcoidosis following chemotherapy of Hodgkin's disease. Indian J Dermatol Venereol Leprol. 2003;69:220–222
  29. Diette KM, Caro WA, Roenigk HH. Malignant lymphoma presenting with cutaneous granulomas. J Am Acad Dermatol. 1984;10:896–902
  30. Randle HW, Banks PM, Winkelmann RK. Cutaneous granulomas in malignant lymphoma. Arch Dermatol. 1980;116:441–443
  31. Dunphy CH, Panella MJ, Grosso LE. Low-grade B-cell lymphoma and concomitant extensive sarcoidlike granulomas. A case report and review of the literature. Arch Pathol Lab Med. 2000;124:152–156
  32. Mauduit G, Souteyrand F, Cambazard F, Faure M, Hermier C, Thivolet J. Non-epidermotropic malignant cutaneous lymphoma and sarcoidosis. Ann Dermatol Venereol. 1983;110:59–62
  33. Farrell AM, Henry K, Woodrow D, et al. Cutaneous granulomas associated with high-grade T-cell non-Hodgkin's lymphoma. Br J Dermatol. 1999;140:145–149
  34. Onisuka A, Katagiri Y, Kiyama S, et al. Hilar cholangiocarcinoma associated with sarcoid reaction in the regional lymph nodes. J Hepatobiliary Pancreat Surg. 2003;10:316–320
  35. Bassler R, Birke F. Histopathology of tumour associated sarcoid-like stromal reaction in breast cancer. An analysis of 5 cases with immunohistochemical investigations. Virchows Arch A Pathol Anat Histopathol. 1988;412:231–239
  36. Lower EE, Hawkins HH, Baughman RP. Breast disease in sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2001;18:301–306
  37. Kovacs J, Varga A, Bessenyei M, Gomba S. Renal cell cancer associated with sarcoid-like reaction. Pathol Oncol Res. 2004;10:169–171
  38. Marinides GN, Hajdu I, Gand RO. A unique association of renal cell carcinoma with sarcoid reaction in the kidney. Nephron. 1994;67:477–480
  39. Moder KG, Litin SC, Gaffey TA. Renal cell carcinoma associated with sarcoid-like tissue reaction. Mayo Clin Proc. 1990;65:1498–1501
  40. Bottone AC, Labarbera M, Asadourian A, Barman A, Richie C. Renal sarcoidosis coexisting with hypernephroma. Urology. 1993;41:157–159
  41. Campbell F, Douglas-Jones AG. Sarcoid-like granulomas in primary renal cell carcinoma. Sarcoidosis. 1992;10:128–131
  42. Lucci S, Rivolta R, Fazi M. Sarcoidosis and clear cell carcinoma of the kidney: the sixth case?. G Chir. 2002;23:75–78
  43. Parra ER, Canzian M, Saber AMA, et al. Pulmonary and mediastinal “sarcoidosis” following surgical resection of cancer. Pathol Res Pract. 2004;200:701–705
  44. Laurgerg P. Sarcoid reactions in pulmonary neoplasms. Scand J Respir Dis. 1975;56:20–27
  45. Kamiyoshihara M, Hirai T, Kawashima O. Sarcoid reactions in primary pulmonary carcinoma. Report of seven cases. Oncol Rep. 1998;5:177–180
  46. Echigo T, Saito A, Takehara K, Takata M, Hatta N. Coexistence of micrometastatic melanoma cells and sarcoid granulomas in all regional lymph nodes in a patient with acral melanoma. Clin Exp Dermatol. 2003;28:375–376
  47. Dictl J, Horny HP, Ruck P, Kaiserling E. Dysgerminoma of the ovary: an immunohistochemical study of tumor-infiltrating lymphoreticular cells and tumor cells. Cancer. 1993;71:2562–2568
  48. Shigematsu H, Kurita A, Omura Y, Kubo Y, Takashima S, Mandai K. Gastric cancer with sarcoid reactions in the regional lymph nodes, the stomach wall, and the splenic parenchyma: report of a case. Surg Today (Tokyo). 1999;29:549–552
  49. Fossa AD, Abeler V, Marton PF, Lien H, Hoie J. Sarcoid reaction of hilar and paratracheal lymph nodes in patients treated for testicular cancer. Cancer. 1985;56:2212–2216
  50. Toner GC, Bosl W. Sarcoidosis, “sarcoid-like lymphadenopathy,” and testicular germ cell tumors. Am J Med. 1990;89:651–656
  51. Caras WE, Dillard T, Baker T, Pluss J. Coexistence of sarcoidosis and malignancy. South Med J. 2003;96:918–922
  52. Reich JM, Mullooly JP, Johnson RE. Linkage analysis of malignancy-associated sarcoidosis. Chest. 1995;107:605–613
  53. Suen JS, Forse MS, Hyland RH, Chan CK. The malignancy-sarcoidosis syndrome. Chest. 1990;98:1300–1302
  54. Oliwiecki S, Kingston T, Kotecha B, Rothera MP. Sarcoidosis-lymphoma syndrome. J Royal Soc Med. 1992;85:176–177
  55. Seersholm N, Vestbo J, Viskum K. Risk of malignant neoplasms in patients with pulmonary sarcoidosis. Thorax. 1997;52:892–894
  56. Brincker H, Wilbek E. The incidence of malignant tumours in patients with respiratory sarcoidosis. Br J Cancer. 1974;29:247–251
  57. Artinian V, Kvale PA. Cancer and interstitial lung disease. Curr Opin Pulm Med. 2004;10:425–434
  58. Romer FK. Sarcoidosis and cancer—a critical view. In:  Jones Williams J,  Davies BH editor. Proceedings of the VIIIth International Conference on Sarcoidosis. Cardiff: Alpha Omega Press; 1980;p. 567–571
  59. Romer FK, Hommelgaard P, Schou G. Sarcoidosis and cancer revisited: a long-term follow-up study of 555 Danish sarcoidosis patients. Eur Respir J. 1998;12:906–912
  60. Romer FK, Schou G. Sarcoidosis and cancer revisited. From the authors. [letter] Eur Respir J. 1999;14:483
  61. Reich JM. Sarcoidosis and cancer revisited. [letter] Eur Respir J. 1999;14:482–483
  62. Askling J, Grunewald J, Eklund A, Hillerdal G, Ekbom A. Increased risk for cancer following sarcoidosis. Am J Respir Crit Care Med. 1999;160:1668–1672
  63. Murphy EA, Murphy JA, Sturrock RD, Jackson R. Sarcoidosis and acute myeloid leukaemia. J Royal Soc Med. 1991;84:368–369
  64. Reich J. Sarcoidosis and acute leukaemia. [letter] J Royal Soc Med. 1992;85:306
  65. Maloisel F, Oberling F. Acute myeloid leukaemia complicating sarcoidosis. [letter] J Royal Soc Med. 1992;85:58–59
  66. Burney IA, Tai JM, Shah S, Khurshid M. Acute myeloid leukemia following regression of sarcoidosis: a case report. Pakistan J Med Res. 2002;41:39;http://www.pmrc.org.pk/aml.htm
  67. Brincker H. The sarcoidosis-lymphoma syndrome. Br J Cancer. 1986;54:467–473
  68. Pietropaoli A, Modrak J, Utell M. Interferon-alpha therapy associated with the development of sarcoidosis. Chest. 1999;116:569–572
  69. Fiorani C, Sacchi S, Bonacorsi G, Cosenza M. Systemic sarcoidosis associated with interferon-alpha treatment for chronic myelogenous leukemia. [letter] Haematologica. 2000;85:1006–1007
  70. Kikawada M, Ichinose Y, Kunisawa A, et al. Sarcoidosis induced by interferon therapy for chronic myelogenous leukaemia. Respirology. 1998;3:41–44
  71. Serratrice J, Granel B, Swiader L, et al. Sarcoidosis preceding chronicmyelomonocytic leukemia: report of two cases. Dermatology. 2002;205:409–412
  72. Schiller G, Said J, Pal S. Hairy cell leukemia and sarcoidosis: a case report and review of the literature. [letter] Leukemia. 2003;17:2057–2059doi: 10.1038/sj.leu.2403074
  73. Berthiot G. Hairy-cell leukemia and sarcoidosis. Eur J Med. 1993;2:61
  74. Myers TJ, Granville NB, Witter BA. Hairy cell leukemia and sarcoid. Cancer. 1979;43:1777–1781
  75. Karakantza M, Matutes E, MacLennan K, O'Connor NTJ, Srivastava PC, Catovsky D. Association between sarcoidosis and lymphoma revisited. J Clin Pathol. 1996;49:208–212
  76. Siekierska-Hellmann M, Sworczak K. Sarcoidosis-lymphoma syndrome in a woman with acromegaly. [letter] Postgrad Med J. 1998;74:382
  77. Merchant TE, Filippa DA, Yahalom J. Sarcoidosis following chemotherapy for Hodgkin's disease. Leuk Lymphoma. 1994;13:339–347
  78. Simsek S, van Leuven F, Bronsveld W, Ooms GH, Groeneveld ABJ, de Graaff CS. Unusual association of Hodgkin's disease and sarcoidosis. J Med. 2002;60:438–440
  79. deLeon DG, Shifteh S, Cunha BA. FUO due to sarcoidosis-lymphoma syndrome. Heart Lung. 2004;33:124–129
  80. Finke R, Lydtin H, Prechtel K. Sarcoidosis and immunocytoma. Am J Med. 1986;80:939–942
  81. Keohane SG, Savin JA, Tidman MJ, Anderson JAM, Carey FA. Thesarcoidosis-lymphoma syndrome: acceleration of cutaneous sarcoidosis during chemotherapy of the lymphoma. [letter] Acta Derm Venereol (Stockh). 1996;76:251–253
  82. Romero J, Ramon y Cajal S, Vargas JA, et al. Association of sarcoidosis, low-grade B-lymphoma and epidermoid carcinoma. Postgrad Med J. 1997;73:580–582
  83. Haran MZ, Feldberg E, Berrebi A. Lymphoma masking sarcoidosis. Leuk Lymphoma. 2002;43:1709–1710
  84. Ryan PJ, Stableforth P, McLeod DT. Co-existing conjunctival non-Hodgkin's lymphoma and pulmonary sarcoidosis. Thorax. 1996;51:444–445
  85. Nakamura Y, Kurihara N, Sato A, et al. Muscle sarcoidosis following malignant lymphoma: diagnosis by MR imaging. Skeletal Radiol. 2002;31:702–705doi: 10.1007/s00256-002-0539-3
  86. Masuda R, Toyoshima H, Bandou T, Isoyama T, Matsui Y, Takemura T. Malignant lymphoma of the stomach associated with systemic sarcoidosis. Cancer. 1992;70:2592–2596
  87. Fukuda T, Sato K, Tachikawa S, Ohnuki K, Ohtani H, Suzuki T. Mucosa-associated lymphoid tissue lymphoma coexisting with epithelioid granulomas in the stomach of a patient with systemic sarcoidosis. Pathol Int. 1997;47:870–875
  88. Gelfand JM, Wasik MA, Vittorio C, Rook A, Junkins-Hopkins JM. Progressive epidermotropic CD8+/CD4− primary cutaneous CD30+ lymphoproliferative disorder in a patient with sarcoidosis. J Am Acad Dermatol. 2004;51:304–308
  89. Gelfand JM. CD30+,CD8+, CD4− cutaneous lymphoma with sarcoidosis. [abstract] Dermatol Online J. 2001;7:24F
  90. Schmuth M, Prior C, Illersperger B, Topar G, Fritsch P, Sepp N. Systemic sarcoidosis and cutaneous lymphoma: is the association fortuitous?. Br J Dermatol. 1999;140:952–955
  91. Brincker H. Sarcoidosis and malignancy. [Letter] Chest. 1995;108:1472–1474
  92. Theate Ik, Michaux L, Dardenne S, et al. Epstein-Barr virus–associated lymphoproliferative disease occurring in a patient with sarcoidosis treated by methotrexate and methylprednisolone. Eur J Haematol. 2002;69:248–253
  93. Sen F, Mann KP, Medeiros JL. Multiple myeloma in association with sarcoidosis: a case report and review of the literature. Arch Pathol Lab Med. 2002;126:365–368
  94. Bobbio-Pallavicini E, Valsecchi C, Tacconi F, Moroni M, Porta C. Sarcoidosis following beta-interferon therapy for multiple myeloma. Sarcoidosis. 1995;12:140–142
  95. Gaja A, Frankova H, Kock I, Slapnickova J, Hejlova N. Treatment with interferon and autoimmunity. Vnitr Lek. 1999;45:409–413
  96. Brincker H. Solid tumors preceding or following sarcoidosis. Med Pediatr Oncol. 1987;15:82–88
  97. Yanagawa H, Goto H, Maniwa K, et al. A case of respectable lung adenocarcinoma associated with sarcoidosis. Med Oncol. 1999;16:216–220
  98. Yamasawa H, Ishii Y, Kitamura S. Concurrence of sarcoidosis and lung cancer: a report of four cases. Respiration. 2000;67:90–93
  99. Garcia CA, Rosenberg RJ, Spencer RP. FDG-positron emission tomographic imaging in carcinoma of the breast. Interference by massive sarcoidosis. Clin Nucl Med. 2003;28:218–219
  100. Levy NT, Rubin J, DeRemee RA, Aughenbaugh GL, Unni KK, Kahn MJ. Carcinoid tumors and sarcoidosis—does a link exist?. Mayo Clin Proc. 1997;72:112–116
  101. Okada M, Tanaka M, Horiuchi N, Kato T, Tagami H. Coexistence of xeroderma pigmentosum with sarcoidosis and adenocarcinoma of the digestive organs. Acta Derm Venereol. 2000;80:376–377
  102. Roth D, West B, Madison J, Cooper D. Gastric carcinoma in a patient with sarcoidosis of the gastrointestinal tract. Am J Gastroenterol. 1994;89:1589–1591
  103. Alliot C, Barrios M, Desplechain C. Multisystem sarcoidosis and carcinoma of the uterine cervix: an unusual association. Int J Gynecol Cancer. 2001;11:323–325
  104. Ravenel JG, McAdams HP, Plankeel JF, Butnor KJ, Sporn TA. Sarcoidosis induced by interferon therapy. Case report. AJR Am J Roentgenol. 2001;177:199–201
  105. Abdi EA, Nguyen GK, Ludwig RN, Dickout WJ. Pulmonary sarcoidosis following interferon therapy for advanced renal cell carcinoma. Cancer. 1987;59:896–900
  106. Logan TF, Bensadoun ES. Increased disease activity in a patient with sarcoidosis after high dose interleukin 2 treatment for metastatic renal cancer. Thorax. 2005;60:610–611
  107. Muggia FM, Conti PS. Seminoma and sarcoidosis: a cause for false positive mediastinal uptake in PET?. [letter] Ann Oncol. 1998;9:924
  108. Rayson D, Burch PA, Richardson RL. Sarcoidosis and testicular carcinoma. Cancer. 1998;83:337–343
  109. Suzuki M, Ohaya K, Nagamatsu H, Mizuo T. Sarcoidosis in a young woman with bladder carcinoma. J Urol. 1998;160:123
  110. Yao M, Funk GF, Goldstein DP, DeYoung BR, Graham MM. Benign lesions in cancer patients: case 1. Sarcoidosis after chemoradiation for head and neck cancer. J Clin Oncol. 2005;23:640–641
  111. Chalasani P, Vohra M, Sheagren JN. An association of sarcoidosis with hepatocellular carcinoma. Ann Oncol. 2005;16:1714–1715
  112. Massaguer S, Sanchez M, Castel T. Mediastinal sarcoidosis induced by high-dose alpha-2-interferon therapy in a patient with malignant melanoma. Eur Radiol. 2004;14:1716–1717
  113. Mackenzie H, Retsas S. Malignant melanoma co-existing with sarcoidosis: implications for prognosis and management. Melanoma Res. 1996;6:71–72
  114. Rubinstein I, Baum GL, Yellin A, Herozeg E. Sarcoidosis: a cause of bilateral hilar lymphadenopathy after excision of malignant melanoma of the arm. South Med J. 1985;78:1139–1140
  115. McLoone NM, McKenna K, Edgar D, Walsh M, Bingham A. Merkel cell carcinoma in a patient with chronic sarcoidosis. Clin Exp Dermatol. 2005;30:580–582
  116. Mao JT, Fishbein MC. Metastatic pancreatic cancer masquerading as pulmonary sarcoidosis. [letter] Am J Med. 2000;109:598–599
  117. Corda L, Benerecetti D, Ungari M, Facchetti F, Radaeli E. Kaposi's disease and sarcoidosis. Eur Respir J. 1996;9:383–385
  118. Okada K, Sasaki M, Nanjo H, Ito M, Takahashi S, Itoi E. Benign lesions in cancer patients: case 2. Unusual association of osteosarcoma and sarcoidosis. J Clin Oncol. 2005;23:641–643
  119. Sybert A, Butler TP. Sarcoidosis following adjuvant high-dose methotrexate therapy for osteosarcoma. Arch Intern Med. 1978;138:488–489
  120. American Thoracic Society . Statement on sarcoidosis. Am J Respir Crit Care Med. 1999;160:736–755
  121. Reich JM. Malignant neoplasms in pulmonary sarcoidosis. [letter] Thorax. 1998;53:625–626
  122. Sacchi S, Kantarjian H, O'Brien S, Cohen PR, Pierce S, Talpaz M. Immune-mediated and unusual complications during interferon alfa therapy in chronic myelogenous leukemia. J Clin Oncol. 1995;13:2401–2407

PII: S0738-081X(07)00064-8

doi: 10.1016/j.clindermatol.2007.03.010

Clinics in Dermatology
Volume 25, Issue 3 , Pages 326-333 , May 2007