Clinics in Dermatology
Volume 25, Issue 3 , Pages 288-294 , May 2007

Erythema nodosum

  • Juan Mana

      Affiliations

    • Department of Internal Medicine, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Bellvitge University Hospital, University of Barcelona, Barcelona, Spain
    • Corresponding Author InformationCorresponding author. Servei de Medicina Interna, Hospital Universitari de Bellvitge, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
    • ,
  • Joaquim Marcoval

      Affiliations

    • Department of Dermatology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Bellvitge University Hospital, University of Barcelona, Barcelona, Spain

References 

  1. Hannuksela M. Erythema nodosum. Clin Dermatol. 1986;4:88–95
  2. Verrier Jones J, Cumming RH, Asplin CM, et al. Circulating immune complexes in erythema nodosum and early sarcoidosis. Lancet. 1976;1:153
  3. Saint-Remy JR, Mitchell DN, Cole PJ. Variation in immunoglobulin levels and circulating immune complexes in sarcoidosis. Correlation with extent of disease and duration of symptoms. Am Rev Respir Dis. 1983;127:23–27
  4. Scadding JG, Mitchell DN. In: Sarcoidosis. London: Chapman and Hall; 1985;p. 72–100
  5. Löfgren S. Erythema nodosum. Studies on etiology and pathogenesis in 185 adult cases. Acta Med Scand. 1946;124(Suppl 174):1–197
  6. Löfgren S. The concept of erythema nodosum revised. Scand J Respir Dis. 1967;48:348–353
  7. James DG. Erythema nodosum. Br Med J. 1961;1:853–857
  8. García-Porrúa C, González-Gay MA, Vázquez-Caruncho M, et al. Erythema nodosum. Etiologic and predictive factors in a defined population. Arthritis Rheum. 2000;43:584–592
  9. Löfgren S, Lundbäck H. The bilateral hilar lymphoma syndrome. A study of the relation to age and sex in 212 cases. Acta Med Scand. 1952;142:259–264
  10. Löfgren S, Lundbäck H. The bilateral hilar lymphoma syndrome. A study of the relation to tuberculosis and sarcoidosis in 212 cases. Acta Med Scand. 1952;142:265–273
  11. Löfgren S. Primary pulmonary sarcoidosis. I. Early signs and symptoms. Acta Med Scand. 1953;145:424–431
  12. Löfgren S. Primary pulmonary sarcoidosis. II. Clinical course and prognosis. Acta Med Scand. 1953;145:465–474
  13. James DG, Thomson AD, Willcox A. Erythema nodosum as a manifestation of sarcoidosis. Lancet. 1956;2:218–221
  14. Hannuksela M, Salo OP, Mustakallio KK. The prognosis of acute untreated sarcoidosis. Ann Clin Res. 1970;2:57–61
  15. Siltzbach LE, James DG, Neville E, et al. Course and prognosis of sarcoidosis around the world. Am J Med. 1974;57:847–852
  16. James DG, Neville E, Siltzbach LE, et al. A worldwide review of sarcoidosis. Ann N Y Acad Sci. 1976;278:321–334
  17. Neville E, Walker AN, James DG. Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients. Q J Med. 1983;52:525–533
  18. Milman N, Selroos O. Pulmonary sarcoidosis in the Nordic countries 1950-1982. Epidemiology and clinical picture. Sarcoidosis. 1990;7:50–57
  19. Mañá J, Badrinas F, Morera J, et al. Sarcoidosis in Spain. Sarcoidosis. 1992;9:118–122
  20. Fité E, Alsina JM, Mañá J, et al. Epidemiology of sarcoidosis in Catalonia: 1979-1989. Sarcoidosis Vasc Diffuse Lung Dis. 1996;13:153–158
  21. British Thoracic and Tuberculosis Association . Geographical variations in the incidence of sarcoidosis in Great Britain: a comparative study of four areas. Tubercle. 1969;50:211–332
  22. Badrinas F, Morera J, Fité E, et al. Seasonal clustering of sarcoidosis. Lancet. 1989;2:455–456
  23. Glennas A, Kvien TK, Melby K, et al. Acute sarcoid arthritis: occurrence, seasonal onset, clinical features and outcome. Br J Rheumatol. 1995;34:45–50
  24. Mañá J, Gómez-Vaquero C, Montero A, et al. Löfgren's syndrome revisited: a study of 186 cases. Am J Med. 1999;107:240–245
  25. Wilsher ML. Seasonal clustering of sarcoidosis presenting with erythema nodosum. Eur Respir J. 1998;12:1197–1199
  26. Smith MJ, Turton CWG, Mitchell DN, et al. Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax. 1981;36:296–298
  27. Hedfors E, Lindström F. HLA-B8/DR3 in sarcoidosis. Tissue Antigens. 1983;22:200–203
  28. Berlin M, Fogdell-Hahn A, Olerup O, et al. HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis. Am J Respir Crit Care Med. 1997;156:1601–1605
  29. Bogunia-Kubik K, Tomeczko J, Suchnicki K, et al. HLA-DRB1*03, DRB1*11 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis. Tissue Antigens. 2001;57:87–90
  30. Sato H, Grutters JC, Pantelidis P, et al. HLA-DQB1*0201. A marker for good prognosis in British and Dutch patients with sarcoidosis. Am J Cell Mol Biol. 2002;27:406–412
  31. Grunewald J, Eklund A, Olerup O. Human leukocyte antigen class I alleles and the disease course in sarcoidosis patients. Am J Respir Crit Care Med. 2004;169:696–702
  32. Grutters JC, Sato H, Pantelidis P, et al. Increased frequency of the uncommon tumor necrosis factor −857T allele in British and Dutch patients with sarcoidosis. Am J Respir Crit Care Med. 2002;165:1119–1124
  33. Spagnolo P, Renzoni EA, Wells AU, et al. C-C chemokine receptor 2 and sarcoidosis. Association with Löfgren's syndrome. Am J Respir Crit Care Med. 2003;168:1162–1166
  34. Valentonyte R, Hampe J, Croucher PJP, et al. Study of C-C chemokine receptor 2 alleles in sarcoidosis, with emphasis on family-based analysis. Am J Respir Crit Care Med. 2005;171:1136–1141
  35. Mrazek F, Holla LI, Hutyrova B, et al. Association of tumor necrosis factor-α, lymphotoxin-α and HLA-DRB1 gene polymorphisms with Löfgren's syndrome in Czech patients with sarcoidosis. Tissue Antigens. 2005;65:163–171
  36. Valeyre D, Saumon G, Georges R, et al. The relationship between disease duration and non-invasive pulmonary explorations in sarcoidosis with erythema nodosum. Am Rev Respir Dis. 1984;129:938–943
  37. Ho LP, Urban BC, Thickett DR, et al. Deficiency of a subset of T cells with immunoregulatory properties in sarcoidosis. Lancet. 2005;365:1062–1072
  38. Caplan HI, Katz WA, Rubenstein M. Periarticular inflammation, bilateral hilar adenopathy and a sarcoid reaction. Arhritis Rheum. 1970;13:101–111
  39. Pennec Y, Youinou P, Le Goff P, et al. Comparison of the manifestations of acute sarcoid arthritis with and without erythema nodosum. Scand J Rheumatol. 1982;11:13–16
  40. Perruquet JL, Harrington TM, Davis DE, et al. Sarcoid arthritis in a North American Caucasian population. J Rheumatol. 1984;11:521–525
  41. Israel HL, Fish JE. Periarticular ankle sarcoidosis and Löfgren's syndrome. Sarcoidosis. 1994;11(Suppl 1):379–388
  42. Mañá J, Gómez-Vaquero C, Salazar A, et al. Periarticular ankle sarcoidosis: a variant of Löfgren's syndrome. J Rheumatol. 1996;23:874–877
  43. Visser H, Vos K, Zanelli E, et al. Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors. Ann Rheum Dis. 2002;61:499–504
  44. Kellner H, Späthling S, Herzer P. Ultrasound findings in Löfgren's syndrome: is ankle swelling caused by arthritis, tenosynovitis or periarthritis?. J Rheumatol. 1992;19:38–41
  45. Mañá J, Marcoval J, Graells J, et al. Cutaneous involvement in sarcoidosis. Relationship to systemic disease. Arch Dermatol. 1997;133:882–888
  46. Marcoval J, Mañá J, Moreno A, et al. Subcutaneous sarcoidosis—clinicopathological study of 10 cases. Br J Dermatol. 2005;153:790–794
  47. Marcoval J, Moreno A, Mañá J. Papular sarcoidosis of the knees: a clue for the diagnosis of erythema nodosum–associated sarcoidosis. J Am Acad Dermatol. 2003;49:75–78
  48. Grönhagen-Riska C, Selroos O, Wägar G, et al. Angiotensin-converting enzyme. II. Serum activity in early and newly diagnosed sarcoidosis. Scand J Respir Dis. 1979;60:94–101
  49. Romer FK. Angiotensin-converting enzyme in newly detected sarcoidosis. Acta Med Scand. 1980;208:437–443
  50. Teirstein AS, Krumholtz S. Assessment of serum angiotensin-converting enzyme as a marker of activity in sarcoidosis: a study of 31 patients with erythema nodosum. Mt Sinai Med J. 1987;54:144–146
  51. Israel HL, Albertine KH, Park CH, et al. Whole-body gallium-67 scans. Role in the diagnosis of sarcoidosis. Am Rev Respir Dis. 1991;144:1182–1186
  52. Sulavik SB, Spencer RP, Palestro CJ, et al. Specificity and sensitivity of distinctive chest radiograph and/or gallium-67 images in the non-invasive diagnosis of sarcoidosis. Chest. 1993;103:403–409
  53. Mañá J, Teirstein AS, Mendelson DS, et al. Excessive thoracic computed tomographic scanning in sarcoidosis. Thorax. 1995;50:1264–1266
  54. Winterbauer RH, Belic N, Moores KD. A clinical interpretation of bilateral hilar adenopathy. Ann Intern Med. 1973;78:65–71
  55. Carr PL, Singer DE, Goldenheim P, et al. Noninvasive testing of asymptomatic bilateral hilar adenopathy. J Gen Intern Med. 1990;5:138–146
  56. Mañá J, van Kroonenburgh M. Clinical usefulness of nuclear imaging techniques in sarcoidosis. Eur Respir Mon. 2005;32:284–300
  57. Walsh NMG, Hanly JG, Tremaine R, et al. Cutaneous sarcoidosis and foreign bodies. Am J Dermatopathol. 1993;15:203–207
  58. Val-Bernat JF, Sanchez-Quevedo MC, Corral J, et al. Cutaneous sarcoidosis and foreign bodies: an electron probe roentgenographic microanalytic study. Arch Pathol Lab Med. 1995;119:471–474
  59. Marcoval J, Mañá J, Moreno A, et al. Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Arch Dermatol. 2001;137:427–430
  60. Munro CS, Mitchell DN. The Kveim response: still useful, still a puzzle. Thorax. 1987;42:321–331
  61. Mañá J, Pujol R, Salazar A, et al. La prueba de Kveim-Siltzbach en la sarcoidosis. Med Clin (Barc). 1995;104:645–647
  62. Selroos O. The frequency, clinical picture and prognosis of pulmonary sarcoidosis in Finland. Acta Med Scand. 1969;(Suppl 503):1–73
  63. Milman N, Selroos O. Pulmonary sarcoidosis in the Nordic countries 1950-1982. II. Course and prognosis. Sarcoidosis. 1990;7:113–118
  64. Mañá J, Salazar A, Manresa F. Clinical factors predicting persistence of activity in sarcoidosis: a multivariate analysis of 193 cases. Respiration. 1994;61:219–225
  65. Mañá J, Salazar A, Pujol R, et al. Are the pulmonary function tests and the markers of activity helpful to establish the prognosis of sarcoidosis?. Respiration. 1996;63:298–303
  66. Olive KE, Kataria YP. Cutaneous manifestations of sarcoidosis. Relationships to other organ system involvement, abnormal laboratory measurements, and disease course. Arch Intern Med. 1985;145:1811–1814
  67. Sones M, Israel HL. Course and prognosis of sarcoidosis. Am J Med. 1960;29:84–93
  68. Mañá J, Montero A, Vidal M, et al. Recurrent sarcoidosis: a study of 17patients with 24 episodes of recurrence. Sarcoidosis Vasc Diffuse Lung Dis. 2003;20:212–221

PII: S0738-081X(07)00060-0

doi: 10.1016/j.clindermatol.2007.03.006

Clinics in Dermatology
Volume 25, Issue 3 , Pages 288-294 , May 2007

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