Clinics in Dermatology
Volume 24, Issue 4 , Pages 281-288 , July 2006

Dermatologic manifestations of parathyroid-related disorders

  • Ghada El-Hajj Fuleihan, MD

      Affiliations

    • Division of Endocrinology, Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, 4407 2020 Beirut, Lebanon
    • Corresponding Author InformationCorresponding author. Tel.: +1 961 3 679903; fax: +1 961 1 745321/961 1 744464.
  • ,
  • Nelly Rubeiz, MD

      Affiliations

    • Department of Dermatology, American University of Beirut Medical Center, 4407 2020 Beirut, Lebanon

References 

  1. El-Hajj Fuleihan G. Parathyroid hormone secretion and action. In UpToDate CD ROM 14.1.
  2. Diaz R, El-Hajj Fuleihan G, Brown EM. Regulation of parathyroid function. In:  Fray GCS editors. Handbook of Physiology, section 7: Endocrinology, volume III: Hormonal regulation water and electrolyte balance. New York: Oxford University Press; 1999;
  3. Kronenberg HM, Bringhurst RF, Segre GV, Potts JT. Parathyroid hormone biosynthesis and metabolism. In:  Bilezikian JP,  Marcus R,  Levine MA editor. The parathyroids: basic and clinical concepts. New York: Academic Press; 2001;p. 17–30
  4. Brown EM, Pollak M, Seidman CE, et al. Calcium-ion sensing cell surface receptors. N Engl J Med. 1995;333:234–240
  5. Bilezikian JP, Brandi ML, Rubin M, Silverberg SJ. Primary hyperparathyroidism: new concepts in clinical, densitometric and biochemical features. J Int Med. 2005;257:6–17
  6. El-Hajj Fuleihan G. Clinical manifestations of hyperparathyroidism. In UpToDate CD ROM 14.1.
  7. El-Hajj Fuleihan G, Brown EM, Heath H. The familial benign hypocalciuric hypercalcemic syndromes. In:  Bilezikian JP,  Raisz LG,  Rodan GA editor. Principles of bone biology. San Diego (Calif): Academic Press; 2002;p. 1031–1046
  8. Marx SJ, Stratakis CA. Multiple endocrine neoplasia—Introduction. J Int Med. 2005;257:2–5
  9. Andrew A. Clinical manifestations and diagnosis of multiple endocrine neoplasia type 2. In UpToDate CD ROM 14.1.
  10. Leonhardt JM, Heymann WR. Cutaneous manifestations of other endocrine diseases. In:  Freedberg IM,  Eisen AZ,  Wolff K, et al. editor. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw-Hill; 2003;p. 1662–1670
  11. Dagher HN, Aboujaoude ZC, Jabbour SA. Chronic urticaria: an unusual manifestation of primary hyperparathyroidism. Endocr Pract. 2002;8:47–49
  12. Argawal SK, Burns AL, Sukhodolets KE, et al. Molecular pathology of the MEN1 gene. Ann NY Acad Sci. 2004;1014:189–198
  13. Pack S, Turner ML, Zhuang Z, et al. Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the Men1 gene. J Invest Dermatol. 1998;11:438–440
  14. Ceccherini I, Romei C, Barone V, et al. Identification of the Cys634→Tyr mutation of the RET proto-oncogene in a pedigree with multiple endocrine neoplasia type 2A and localized cutaneous amyloidosis. J Endocrinol Invest. 1994;17:201–204
  15. Verga U, Fugazzola L, Cambiaghi S, et al. Frequent association between MEN 2A and cutaneous lichen amyloidosis. Clin Endocrinol. 2003;59:156–161
  16. Walsh JS, Fairley JA. Cutaneous mineralization and ossification. In:  Freedberg IM,  Eisen AZ,  Wolff K, et al. editor. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw-Hill; 2003;p. 1490–1496
  17. Selye H. In: Calciphylaxis. Chicago (Ill): University of Chicago Press; 1962;p. 1–100
  18. Hafner J, Keusch G, Wahl C, et al. Uremic small-artery disease with medial calcification and intimal hyperplasia (so-called calciphylaxis): a complication of chronic renal failure and benefit from parathyroidectomy. J Am Acad Dermatol. 1995;33:954–962
  19. Angelis M, Wong LL, Myers SA, et al. Caciphylaxis in patients on hemodialysis: a prevalence study. Surgery. 1997;122:1083–1090
  20. Zouboulis CC, Blume-peytavi U, Lennert T, et al. Fulminant metastatic calcinosis with cutaneous necrosis in a child with end-stage renal disease and tertiary hyperparathyroidism. Br J Dermatol. 1996;135:617–622
  21. Mirza I, Chaubay D, Gunderia H, et al. An unusual presentation of calciphylaxis due to primary hyperparathyroidism. Arch Pathol Lab Med. 2001;125:1351–1353
  22. Oh DH, Eulau D, Tokugawa DA, et al. Five cases of calciphylaxis and a review of the literature. J Am Acad Dermatol. 1999;40:979–987
  23. Hafner J, Keusch G, Wahl C, Burg G. Calciphylaxis: a syndrome of skin necrosis and acral gangrene in chronic renal failure. Vasa. 1998;27:137–143
  24. Fischer AH, Morris DJ. Pathogenesis of calciphylaxis: study of three cases with literature review. Hum Pathol. 1995;26:1055–1064
  25. Bilezikian JP, Potts JT, El-HajjFuleihan G, et al. Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century. J Clin Endocrinol Metab. 2002;87:5353–5361
  26. Sharma VK, Khandpur S, Khanna N. An interesting case of unilateral angiofibromas successfully treated with pulsed dye laser. J Eur Acad Dermatol Venereol. 2004;18:641–642
  27. Tope WD, Kageyama N. “Hot” KTP-laser treatment of facial angiofibromata. Lasers Surg Med. 2001;29:78–81
  28. Bittencourt RC, Huilgol SC, Seed PT, et al. Treatment of angiofibromas with a scanning carbon dioxide laser: a clinicopathologic study with long-term follow up. J Am Acad Dermatol. 2001;45:731–735
  29. Chou FF, Ho JC, Huang SC, Scheen-Chen SM. A study on pruritus after parathyroidectomy for secondary hyperparathyroidism. J Am Coll Surg. 2000;190:65–70
  30. Stahle-Backdahl M, Hagermark O, Lins LE, et al. Experimental and immunohistochemical studies on the possible role of parathyroid hormone in uremic pruritus. J Int Med. 1989;225:411–415
  31. Podymow T, Wherrett C, Burns KD. Hyperbaric oxygen in the treatment of calciphylaxis: a case series. Nephrol Dial Transplant. 2001;16:2176–2180
  32. Cicone JS, Petronis JB, Embert CD, et al. Successful treatment of calciphylaxis with intravenous sodium thiosulfate. Am J Kidney Dis. 2004;43:1104–1108
  33. Brucculeri M, Cheigh J, Bauer G, et al. Long-term intravenous sodium thiosulfate in the treatment of a patient with calciphylaxis. Semin Dial. 2005;18:431–434
  34. Jabbour SA. Cutaneous manifestations of endocrine disorders: a guide for dermatologists. Am J Clin Dermatol. 2003;4:315–331
  35. Agus Z. Etiology of hypocalcemia in adults. In UpToDate CD ROM 14.1.
  36. Akinsoto OPA, Jabbour SA. Polyglandular autoimmune syndrome, type1. http://www.emedicine.com/med/topic1867.htm
  37. Eddy MC, Jean De Beur SM, Yandow SM, et al. Deficiency of the alpha-subunit of the stimulatory G protein and severe extraskeletal ossification. J Bone Miner Res. 2000;15:2074–2083
  38. Paller A. Primary immunodeficiencies. In:  Freedberg IM,  Eisen AZ,  Wolff K, et al. editor. Fitzpatrick's dermatology in general medicine. 6th ed. New York: McGraw-Hill; 2003;p. 835–852
  39. Aslan Y, Gedik Y, Okten A, et al. Congenital primary hypoparathyroidism presented with extensive cutaneous and sub-cutaneous calcifications. Turk J Pediatr. 1999;41:253–257
  40. Gueydan M, Folchetti G, Christofilis MA, et al. Impetigo herpetiformis, a rare manifestation of severe hypocalcemia. Ann Endocrinol (Paris). 2002;63:502–504
  41. Lee Y, Nam Y-H, Lee J-H, et al. Hypocalcemia-induced pustular psoriasis–like skin eruption. Br J Dermatol. 2005;152:591–593
  42. Aksoylar S, Aydinok Y, Serdaroglu E, et al. HDR (hypoparathyroidism, sensorineural deafness, renal dysplasia) syndrome presenting with hypocalcemia-induced generalized psoriasis. J Pediatr Endocrinol Metab. 2004;17:1031–1034
  43. Kirkpatrick CH. Chronic mucocutaneous candidiasis. J Am Acad Dermatol. 1994;31(3 Pt 2):S14–S17

PII: S0738-081X(06)00045-9

doi: 10.1016/j.clindermatol.2006.04.003

Clinics in Dermatology
Volume 24, Issue 4 , Pages 281-288 , July 2006