Clinics in Dermatology
Volume 24, Issue 2 , Pages 84-87 , March 2006

Immunological aspects of pregnancy

  • Leona Yip, MBChB

      Affiliations

    • Department of Medicine, University of Melbourne, 3010, Melbourne, Australia
  • ,
  • James McCluskey, MD

      Affiliations

    • Department of Microbiology and Immunology, University of Melbourne, 3010, Melbourne, Australia
  • ,
  • Rodney Sinclair, MD

      Affiliations

    • Department of Medicine, University of Melbourne, 3010, Melbourne, Australia
    • Department of Dermatology, St Vincent's Hospital, Fitzroy 3065, Melbourne, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 3 92883293; fax: +61 3 92883292.

References 

  1. Garcka-Gonzalez E, Ahued-Ahued R, Arroyo E, Montes-De-Oca D, Granados J. Immunology of the cutaneous disorders of pregnancy. Int J Dermatol. 1999;38:721–729
  2. Clements CS, Kjer-Nielsen L, Kostenko L, et al. Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proc Natl Acad Sci U S A. 2005;102:3360–3365
  3. Colonna M, Samaridis J, Cella M, et al. Cutting edge: human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol. 1998;160:3096–3100
  4. Allan DS, Lepin EJ, Braud VM, O'Callaghan CA, McMichael AJ. Tetrameric complexes of HLA-E, HLA-F, and HLA-G. J Immunol Methods. 2002;268:43–50
  5. Robinson J, Waller MJ, Parham P, et al. IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res. 2003;31:311–314
  6. Marguiles D, McCluskey J. In:  Paul W editors. Fundamental immunology. Philadelphia: Lippincott; 2003;
  7. Bjorkman PJ, Parham P. Structure, function, and diversity of class I major histocompatibility complex molecules. Annu Rev Biochem. 1990;59:253–288
  8. Schmorl G. Pathologisch-anatomische untersuchungen über puerperal-eklampsie. Leipzig (Germany): Vogel; 1893;
  9. Loke YW, Hiby S, King A. Human leukocyte antigen-G and reproduction. J Reprod Immunol. 1999;43:235–242
  10. van Wijk I, Griffioen S, Tjoa ML, et al. HLA-G expression in trophoblast cells circulating in maternal peripheral blood during early pregnancy. Am J Obstet Gynecol. 2001;184:991–997
  11. LeMaoult J, Le Discorde M, Rouas-Freiss N, et al. Biology and functions of human leukocyte antigen–G in health and sickness. Tissue Antigens. 2003;62:273–284
  12. Ishitani A, Geraghty DE. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. Proc Natl Acad Sci U S A. 1992;89:3947–3951
  13. Hunt JS, Petroff MG, Morales P, et al. HLA-G in reproduction: studies on the maternal-fetal interface. Hum Immunol. 2000;61:1113–1117
  14. Le Bouteiller P, Legrand-Abravanel F, Solier C. Soluble HLA-G1 at the materno-foetal interface—a review. Placenta. 2003;24(Suppl A):S10–S15
  15. Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy. FASEB J. 2005;19:681–693
  16. Ulbrecht M, Rehberger B, Strobel I, et al. HLA-G: expression in human keratinocytes in vitro and in human skin in vivo. Eur J Immunol. 1994;24:176–180
  17. Urosevic M, Dummer R. HLA-G in skin cancer: a wolf in sheep's clothing?. Hum Immunol. 2003;64:1073–1080
  18. Ibrahim el C, Aractingi S, Allory Y, et al. Analysis or HLA antigen expression in benign and malignant melanocytic lesions reveal that upregulation of HLA-G expression correlates with malignant transformation, high inflammatory infiltration and HLA-A1 genotype. Int J Cancer. 2004;108:243–250
  19. Urosevic M, Kempf W, Zagrodnik B, et al. HLA-G expression in basal cell carcinomas of the skin recurring after radiotherapy. Clin Exp Dermatol. 2005;30:422–425
  20. Pawin H. Melanoma and pregnancy. In: Congress proceedings of the 63rd annual meeting of the American Association of Dermatology, New Orleans. February. 2005;
  21. O'Meara AT, Cress R, Xing G, Danielsen B, Smith LH. Malignant melanoma in pregnancy. A population-based evaluation. Cancer. 2005;103:1217–1226
  22. Lens MB, Rosdahl I, Ahlbom A, et al. Effect of pregnancy on survival in women with cutaneous malignant melanoma. J Clin Oncol. 2004;22:4369–4375
  23. Christophers E, Mrowietz U. The inflammatory infiltrate in psoriasis. Clin Dermatol. 1995;13:131–135
  24. Schlaak JF, Buslau M, Jocum W, et al. T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol. 1994;102:145–149
  25. Vogel U, Denecke B, Troyanovsky SM, Leube RE, Bottger EC. Transcriptional activation of psoriasis-associated cytokeratin 17 by interferon-γ. Analysis of interferon-γ activation sites. Eur J Biochem. 1995;227:143–149
  26. Rouas-Freiss N, Marchal R, Kieszenbaum M, Dausset J, Carosella ED. The α1 Domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: is HLA-G the public ligand for natural killer inhibitory receptors?. Proc Natl Acad Sci U S A. 1997;94:5249–5254
  27. Riteau B, Menier C, Khalil-Daher I, et al. HLA-G inhibits the allogeneic proliferative response. J Reprod Immunol. 1999;43:203–211
  28. Le Gal FA, Riteau B, Sedlik C, et al. HLA-G mediated-inhibition of antigen-specific cytotoxic T lymphocytes. Int Immun. 1999;11:101–106
  29. Yang Y, Chu W, Geraghty DE, Hunt JS. Expression of HLA-G in human mononuclear phagocytes and selective induction by IFN-γ. J Immunol. 1996;156:4224–4231
  30. Aractingi S, Briand N, Le Danff C, et al. HLA-G and NK receptor are expressed in psoriatic skin. A possible pathway for regulating infiltrating T cells?. Am J Pathol. 2001;159:71–77
  31. Murase JE, Chan KK, Garite TJ, Cooper DM, Weinstein GD. Hormonal effect on psoriasis in pregnancy and post partum. Arch Dermatol. 2005;141:601–606
  32. Raychaudhuri SP, Navare T, Gross J, Raychaudhuri SK. Clinical course of psoriasis during pregnancy. Int J Dermatol. 2003;42:518–520
  33. Messer G, Schirren H, Meurer M. Herpes gestationis: immunologic and immunogenetic aspects. Hautarzt (Germany) 1993;44:761-6.
  34. Garcka-Gonzalez E, Castro-Llamas J, Karchmer S, et al. Class II histocompatibility complex typing across the ethnic barrier in pemphigoid gestationis: a study in Mexicans. Int J Dermatol. 1999;38:46–51
  35. Shornick JK, Stastnny P, Gilliam JN. High frequency of histocompatibility antigens HLA-DR3 and HLA-DR4 in herpes gestationis. J Clin Invest. 1981;68:553–555
  36. Shornick JK, Stastny P, Gilliam JN. Paternal histocompatibility (HLA) antigens and maternal anti-HLA antibodies in herpes gestationis. J Invest Dermatol. 1983;81:407–409
  37. Kroumpouzos G, Cohen LM. Specific dermatoses of pregnancy: an evidence-based systematic review. Am J Obstet Gynecol. 2003;188:1083–1092
  38. Gazit E, Loewenthal R. The immunogenetics of pemphigus vulgaris. Autoimmun Rev. 2005;4:16–20
  39. Urosevic M, et al. Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2. Blood. 2004;103:1796–1798

PII: S0738-081X(05)00131-8

doi: 10.1016/j.clindermatol.2005.10.022

Clinics in Dermatology
Volume 24, Issue 2 , Pages 84-87 , March 2006